Anish Raju
About
Research
Publications
2024
The relationship between 11 different polygenic longevity scores, parental lifespan, and disease diagnosis in the UK Biobank
Don J, Schork A, Glusman G, Rappaport N, Cummings S, Duggan D, Raju A, Hellberg K, Gunn S, Monti S, Perls T, Lapidus J, Goetz L, Sebastiani P, Schork N. The relationship between 11 different polygenic longevity scores, parental lifespan, and disease diagnosis in the UK Biobank. GeroScience 2024, 46: 3911-3927. PMID: 38451433, PMCID: PMC11226417, DOI: 10.1007/s11357-024-01107-1.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesPolygenic risk scoresDisease-associated variantsPolygenic scoresParental lifespanLarge-scale genome-wide association studiesUK Biobank (UKBEffects of disease-associated variantsTests of associationUK BiobankGenetic architecturePopulation structureAssociation studiesPolygenic basisAssociated with parental lifespanDisease traitsPolygenic componentGenetic variantsRisk scoreDisease susceptibilityHuman longevityGenetic predispositionHealthTraitsHealth span
2022
Hepatic PEMT Expression Decreases with Increasing NAFLD Severity
Piras I, Raju A, Don J, Schork N, Gerhard G, DiStefano J. Hepatic PEMT Expression Decreases with Increasing NAFLD Severity. International Journal Of Molecular Sciences 2022, 23: 9296. PMID: 36012560, PMCID: PMC9409182, DOI: 10.3390/ijms23169296.Peer-Reviewed Original ResearchConceptsPhosphatidylethanolamine N-methyltransferaseNonalcoholic fatty liver diseaseFine-mapping analysisPostmenopausal womenIncreasing severity of NAFLDHepatic fibrosisHigh risk of nonalcoholic fatty liver diseaseIncreasing severity of fibrosisNonalcoholic fatty liver disease patientsSeverity of nonalcoholic fatty liver diseaseRisk of nonalcoholic fatty liver diseaseIncreasing severityNonalcoholic fatty liver disease severityCohort of patientsSeverity of fibrosisGenetic variantsAssociated with NAFLD riskProducts of phosphatidylcholineSpectrum of nonalcoholic fatty liver diseaseGene expressionNormal liver histologyPhosphatidylcholine synthesisFatty liver diseaseN-methyltransferaseNASH patients
2021
Cross-Species and Human Inter-Tissue Network Analysis of Genes Implicated in Longevity and Aging Reveal Strong Support for Nutrient Sensing
Podder A, Raju A, Schork N. Cross-Species and Human Inter-Tissue Network Analysis of Genes Implicated in Longevity and Aging Reveal Strong Support for Nutrient Sensing. Frontiers In Genetics 2021, 12: 719713. PMID: 34512728, PMCID: PMC8430347, DOI: 10.3389/fgene.2021.719713.Peer-Reviewed Original ResearchProtein-protein interaction networkMechanistic target of rapamycinMechanistic target of rapamycin signalingHuman protein-protein interaction networkNetwork analysis of genesSignaling pathwayCross-species orthologsLongevity-associated genesHigh-throughput dataAnalysis of genesCurated gene listsInteractions of proteinsProtein databaseGene listsSpecies genesProtein interactionsNutrient sensingInteraction networkNon-human speciesTarget of rapamycinTarget proteinsCross-speciesBiological pathwaysBiological processesGenes