Francis Y Lee, MD, PhD, FAAOS

Wayne O. Southwick Professor of Orthopaedics and Rehabilitation; with Tenure in Traditional Track; Wayne O. Southwick Endowed Professor in Orthopedics and Rehabilitation; Professor in Department of Pathology, Secondary Appointment; Biological and Biomedical Science Program, YSM Postgraduate School

Departments & Organizations

Orthopaedics & Rehabilitation: Francis Lee Lab | Musculoskeletal Oncology | Ortho Clinical Faculty


Center for Musculoskeletal Care

Yale Cancer Center: Sarcoma Program | Signal Transduction

Yale Medicine


  • Affiliation: Professor with Tenure, Orthopedic Surgeon and Scientist, Department of Orthopedic Surgery, School of Medicine, Yale University (2016-Present); Professor in Pathology, Secondary Appointment, Yale University (2017-Present); Professor with Tenure and Robert Carroll & Jane Chace Carroll Professor, Columbia University, New York (2012-2016); Orthopaedic Attending & Chief of Orthopaedic Oncology, New York Presbyterian Hospital, Columbia University Medical Center, New York (1999-2016)
  • Clinical Practice Locations: Greenwich Hospital, Stamford Office, and Yale New Haven Hospital System
  • Clinical Expertise: Complex Musculoskeletal Reconstruction in Adults and Children; Musculoskeletal Bone and Soft Tissue Tumors & Complex Limb Reconstruction in Adults and Children; Metastatic Cancers to Bone (Breast, Prostate, Thyroid and Others); Osteomyelitis; Pediatric Orthopedics; Osteoid Osteoma, Enchodroma, Osteochondroma, Metabolic and Genetic Bone Diseases, Spine Tumors
  • Research Interest: NIH R01-funded research programs in metastatic cancer-induced bone loss, fracture healing, regenerative orthopedics, and bone infection. Our lab is located in Tompkin 5 Orthopedic Research Laboratories.
  • Administration: Vice Chair of Academic, Scientific, and Research Affairs; Yale School of Medicine Admissions Committee; Yale University Advisor
  • Education: American Board of Orthopaedic Surgery Written Question Task Force, Orthopaedic Research Society Mentorship Committee, New York Orthopaedic Pathology Review Course
  • Current Research Programs & Grants:

- NIH/NIAMS R01 AR 073607 (2018-2023; PI: Francis Y. Lee, M.D.): PTH to rescue impaired fracture healing.

- NIH/NIAMS R01 (2015-2021; PI: Francis Y. Lee, M.D.): Infection and bone destruction; Eradication of bone destruction

- NIH/NCI R01 (2015-2021; PI: Francis Y. Lee, M.D.): Interactions between metastatic cancers and bone; Bone loss

- NIH/NIAMS R01 (2009-2019; PI: Francis Y. Lee, M.D.): Inflammation and bone loss; Osteoclastogenesis

- NIH/NIBIB R01 (2007-2018; PI: Francis Y. Lee, M.D.): Biomaterials interface biology

- Musculoskeletal Transplantation Foundation (2013-2017): Enhanced Allograft Incorporation with Growth Factors

- NIAMS Mentored K08 Award (2017-2022; Mentor for PI Dr. David Koveacevic): Shoulder Inflammation

- Department of Defense (2010-2015; PI: Francis Y. Lee, M.D.): 3D printed scaffolds for bone and cartilage defects

  • External Scholarly Activities:  Musculoskeletal Tumor Society Executive Committee member and Research Committee Chair (2017-2020); National Institute of Health Skeletal Biology, Structure and Regeneration(SBSR) Study Section Permanent Member (2015-2020) and Study Section Chair (2018-2020)
  • Interactions with Undergraduate Students, Medical Students, M.D.-Thesis Medical Students, M.D.-Ph.D. Candidate, Graduate Students, and Post-doctoral Fellows: Please send inquiries to for research and clinical opportunities.
  • Mentoring and Supporting Junior Faculty, Fellows, and Residents: Assisting Career Development Awards or Grants. Academic Promotion Guidance; Primary Mentorship for NIAMS K08 Career Development Award for an Orthopaedic Surgeon at Yale Orthopaedics & Rehabilitation (2017-2022); Mentorship for OREF Residents & Faculty Award
  • Yale University (2016 - Present): Yale University Saybrook College Fellow; Admissions Committee; Biological and Biomedical Science Program
  • Columbia University, New York, and New York Presbyterian Hospital (1999 - 2016): Professor of Orthopaedic Surgery with Tenure (2012-2016), Robert Carroll and Jane Chace Carroll Professor (2014-2016), Associate Professor with Tenure (2009-2012), Associate Professor (2005-2009), Assistant Professor (1999-2005); Orthopedic Surgeon, New York Presbyterian Hospital, New York.

Education & Training

PhD Seoul National University College of Medicine, Orthopedic Basic Science (1992)
MD Seoul National University College of Medicine, Doctor of Medicine (1986)
Honorary Executive MBA Yale School of Management
Clinical Orthopedic Fellowship Hospital for Sick Children, University of Toronto
Clinical Orthopedic Fellowship Harvard Medical School (Mass General Hospital & Boston Children's Hospital)
Orthopedic Research Fellowship Mount Sinai School of Medicine
Orthopaedic Residency Rutgers New Jersey Medical School
Orthopaedic Residency Seoul National University Hospital
Undergraduate Student University of Maryland at U.S. 8th Army, Seoul, Korea
Premed & Doctor of Medicine Seoul National University College of Medicine
Board Certification AB of Orthopaedic Surgery, Orthopaedic Surgery (2001)

Honors & Recognition

  • Best Poster Award, 2nd Place; Osteolytic Metastatic CancersMusculoskeletal Tumor Society (2016)

  • Kappa Delta Ann Doner Vaughn AwardAmerican Academy of Orthopedic Surgeons (2016)

  • Best Paper Award, Second PlaceEuropean Musculoskeletal Tumor Society (2014)

  • J. Neff AwadMusculoskeletal Transplantation Foundation (2014)

  • Career Development AwardOrthopedic Research and Education Foundation (2006)

  • AAOS/OREF/ORS Clinician Scientist Traveling Fellowship AwardAAOS (2005)

  • AOA Resident Traveling Fellowship AwardAmerican Orthopedic Association (1996)

  • Young Investigator AwardInternal Society for Fracture Repair (1996)

Professional Service

  • National Institute of Health Skeletal Biology, Structure, and Reconstruction (SBSR) Study Section (2015 - Present) NIH SBSR Study Section Permanent Member

  • Musculoskeletal Tumor Society (2015 - Present) Research Committee

  • Department of Defense Orthopaedic Trauma PRMRP Study Section Chair (2014)

  • American Academy of Orthopedic Surgeons (2013 - Present) Tumor Program Committee

  • American Academy of Orthopedic Surgeons, Orthopaedic Research Society, Orthopedic Research and Education Foundation (2012 - 2014) Clinician Scholar Development Program Chair

  • American Academy of Orthopedic Surgeons, Orthopaedic Research Society, Orthopedic Research and Education Foundation (2011 - 2015) New Investigator Mentoring Workshop Chair

  • American Board of Orthopedic Surgery (2008 - Present) Orthopedic Surgery Board Written Question Writing

  • NIH, NCI, 2013 NIAMS P50 and P30 Study Section Panel; NIH CSR MTE, SBDD, Skeletal Biology Structure Regeneration (Standing Member 2015-2019), SEP Panel Members; 2017 NIAMS Musculoskeletal Center P50 CORT Review Panel; 2017 NIAMS Musculoskeletal Clinical Research Center P30 Review Panel (2007 - 2016)

  • American Academy of Orthopedic Surgeons (2006 - 2012) Research Development Committee


  • AAOS/OREF/ORS Clinician Scholar Program Rosemont, United States (2017)

    AAOS/OREF/ORS Clinician Scholar Program

  • Lecture Seoul, South Korea (2017)

    Musculoskeletal Infection

  • Musculoskeletal Tumor Society Denver, United States (2017)

    Precision Medicine Prediction Of Skeletal Metastasis: Big Clinical And Gene Profiling Data Analysis

  • Musculoskeletal Tumor Society Denver, United States (2017)

  • Metastatic Breast Cancer Cells Destroy Bone by Inhibiting Ossification and Promoting Osteolytic Cytokine Production: A New Mechanism Kanazawa, Japan (2017 - 2017)

  • Intracellular Staphylococcus Aureus Are Resistant to Antibiotics San Diego, United States (2017 - 2017)

  • Mechanical Integrity of Unseeded, BMP-2 And Canine BMSC Seeded HA-PCL Scaffolds Compared to Allografts in Critical Size Defects in a Canine Model San Diego, United States (2017 - 2017)

  • Osteosarcoma Compartment Stiffness Affects Growth Rate San Diego, United States (2017 - 2017)

  • Trametinib Protects Bone from MRSA Induced Bone Erosion San Diego, United States (2017 - 2017)

  • Aggressive osteolytic breast cancer cells destroy bone by stealing calcium and making osteolytic cytokines: new mechanism and therapeutic target San Diego, United States (2017 - 2017)

  • Local PTH treatment enhances intercalary allograft incorporation San Diego, United States (2017 - 2017)

  • The Hidden Enemy: MRSA-Osteoblast Interaction and Its Consequences in Tissue Destruction and Recurrence Orlando, United States (2016 - 2016)

  • Erk Mediates Aggressive Growth And Bone Destruction In Osteolytic Metastatic Breast Cancers To Bone Orlando, United States (2016 - 2016)

Edit this profile

Contact Info

Francis Y Lee, MD, PhD, FAAOS
Patient Care Locations
Yale Physicians Building
800 Howard Avenue

New Haven, CT 06519
View on map...
Bendheim Cancer Center At Greenwich Hospital
77 Lafayette Place

Greenwich, CT 06830
View on map...
Orthopaedics - Milford
48 Wellington Road

Milford, CT 06461
View on map...
Yale Orthopaedics & Rehabilitation at Stamford, CT260 Long Ridge Road
Stamford, CT 06902
View on map...
Center for Musculoskeletal Care260 Long Ridge Road
Stamford, CT 06902
View on map...
Mailing Address
Orthopaedics & Rehabilitation47 College Street Second Floor
New Haven, CT 06520
Cancer-Induced Bone Loss