Gene editing opens the door to a “revolution” in treating and preventing disease
In a move that seems likely to help clear the path for the use of gene editing in the clinical setting, on February 14 the Committee on Human Gene Editing, formed by the National Academy of Medicine and the National Academy of Sciences, recommended that research into human gene editing should go forward under strict ethical and safety guidelines.
Researchers find genes behind aggressive ovarian and endometrial cancers
In a major breakthrough for ovarian and uterine cancers, Yale researchers have defined the genetic landscape of rare, highly aggressive tumors called carcinosarcomas (CSs), pointing the way to possible new treatments. The findings are published in the Oct. 10 online early edition of Proceedings of the National Academy of Sciences.
Strategies to accelerate diagnosis and treatment of rare cardiovascular diseases
The current landscape for patients with rare cardiovascular disease has shifted. Using genome sequencing Yale physician-scientists have begun to elucidate the pathophysiology of genetic disorders and develop treatment guidelines and recommendations.
Parental Birth Abnormalities and Offspring’s Autism Linked
In a study of medical registry records of nearly 400,000 parent-child pairs from Denmark, a Yale School of Public Health study found that parents who themselves born very prematurely are nearly twice as likely to have children with autism spectrum disorder.
Jawless Lamprey Takes a Bite out of Oncogene Evolution
By carefully tracing the evolution of a select number of cancer-causing genes in a variety of species, the researchers evaluated which animals are — and are not — effective in gauging how an analogue of those genes in humans can lead to cancer. What they found is surprising: jawless fish such as lampreys share significant similarities in these certain genes compared to humans, while fruit flies do not.
Major Gift Will Support an Innovative Brain Research Collaboration
The Swiss-based NOMIS Foundation is making a large five-year award for research into what makes the human brain unique. The research will be a collaboration between the laboratories of James P. Noonan, PhD, associate professor of genetics and of neuroscience at Yale School of Medicine, and Franck Polleux, PhD, professor of neuroscience at Columbia University and a member of that school’s Zuckerman Institute. Their combined mission is to understand the brain and mind.
Geneticist Sidi Chen Receives Large Award Which Will Further His Breast Cancer Work
This Department of Defense award goes to the “best and brightest in their fields,” and recognizes “creative and innovative individuals.” Investigators are chosen for their ability “to go beyond conventional thinking” in their respective areas of expertise.
Major Gift Will Endow a Program Devoted to a Fuller Understanding of How the Human Brain Works
The Thomas Kingsley Lawrence ’19 Program in Brain Research will take a multifaceted approach to understanding the higher-order functionality of the human brain and related areas. It is hoped that with the knowledge gained, novel prevention strategies, diagnostics, and therapeutics to reduce the incidence, prevalence, and recurrence of psychiatric disorders will be possible.
Musings on Mentorship
Three current MD-PhD students--Ryan Chow, Jonathan Park and Matt Dong--are in the laboratory of Assistant Professor Sidi Chen. They are part of the team of authors on a ground-breaking paper published in the journal Nature Immunology in October. Here they give some thoughts on why they enjoy being in the Chen Lab.
Editing mosquito’s gene wards off malaria and halts reproduction
Scientists have looked for immune system factors that might help mosquitoes ward off pathogens such as malarial parasites and indirectly protect humans from infection. Yale researchers found one by editing a single gene, which turns out to be crucial for female reproduction.