2025
Prediction of Hepatitis C Virus Perinatal Transmission in Pregnant Individuals With Hepatitis C Virus Infection
Sandoval G, Saade G, Hughes B, Clifton R, Reddy U, Bartholomew A, Salazar A, Chien E, Tita A, Thorp J, Metz T, Wapner R, Sabharwal V, Simhan H, Swamy G, Heyborne K, Sibai B, Grobman W, El-Sayed Y, Casey B, Parry S, Macones G, Prasad M. Prediction of Hepatitis C Virus Perinatal Transmission in Pregnant Individuals With Hepatitis C Virus Infection. Obstetrics And Gynecology 2025, 145: 449-452. PMID: 40014859, PMCID: PMC11925659, DOI: 10.1097/aog.0000000000005872.Peer-Reviewed Original ResearchConceptsHepatitis C virus infectionPerinatal transmissionHepatitis C virusHepatitis C virus perinatal transmissionPregnant individualsEunice Kennedy Shriver National Institute of Child HealthTransmission of HCV infectionPerinatal transmission rateHCV RNA titersNeonatal follow-upC virus infectionPositive HCV antibodyMulticenter observational studyArea under the curveNational Institute of Child HealthInstitute of Child HealthAntibody-positive participantsAntepartum bleedingHCV infectionHCV antibodiesFollow-upRNA titersC virusObservational studyClinical counselingPrenatal Cannabis Use and Depressive Symptoms
Pitt T, Allshouse A, Kim P, McMillin G, Silver R, Chung J, Grobman W, Haas D, Mercer B, Parry S, Reddy U, Saade G, Simhan H, Metz T. Prenatal Cannabis Use and Depressive Symptoms. Obstetrics And Gynecology 2025, 145: 417-425. PMID: 40014863, PMCID: PMC11925678, DOI: 10.1097/aog.0000000000005860.Peer-Reviewed Original ResearchConceptsAssociated with later depressive symptomsCannabis exposureDepressive symptomsCannabis useTHC-COOHAssociated with increased depressive symptomsAssociated with greater oddsAssociated with depressive symptomsFirst-trimesterExposed to cannabisPregnancy outcome dataWeeks of gestationFirst-trimester exposureGreater oddsCannabis metabolitesSecondary analysisCannabisAssociated with increased oddsExploratory analysisUrine immunoassayTrimesterHigher levelsPrimary outcomePregnancyAcademic centersDeterminants of Racial and Ethnic Differences in Maternal Cardiovascular Health in Early Pregnancy
Cameron N, Huang X, Petito L, Ning H, Shah N, Yee L, Perak A, Haas D, Mercer B, Parry S, Saade G, Silver R, Simhan H, Reddy U, Varagic J, Licon E, Greenland P, Lloyd-Jones D, Kershaw K, Grobman W, Khan S. Determinants of Racial and Ethnic Differences in Maternal Cardiovascular Health in Early Pregnancy. Circulation Cardiovascular Quality And Outcomes 2025, 18: e011217. PMID: 39807595, PMCID: PMC11919558, DOI: 10.1161/circoutcomes.124.011217.Peer-Reviewed Original ResearchMeSH KeywordsAdultBlack or African AmericanCardiovascular DiseasesFemaleHealth Status DisparitiesHispanic or LatinoHumansMaternal HealthPregnancyPregnancy Trimester, FirstRace FactorsResidence CharacteristicsRisk AssessmentRisk FactorsSocial Determinants of HealthSocioeconomic FactorsUnited StatesWhiteWhite PeopleYoung AdultConceptsNon-Hispanic blacksNon-Hispanic whitesNeighborhood-level factorsNon-Hispanic black groupsCardiovascular health scoreMaternal cardiovascular healthNon-Hispanic White groupCardiovascular healthEthnic differencesLife's Essential 8 scoreSuboptimal cardiovascular healthContributions of individual-Public health effortsYears of educationNulliparous individualsReduce disparitiesHealth effortsProportion of differencesCohort studyOffspring outcomesEducational attainmentIndividual-Higher scoresAssess factorsSingleton pregnanciesRadon Exposure and Gestational Diabetes
Zhang Y, Angley M, Lu L, Smith B, Grobman W, Wylie B, Zork N, D’Alton M, McNeil B, Mercer B, Silver R, Simhan H, Haas D, Saade G, Parry S, Reddy U, Kahe K. Radon Exposure and Gestational Diabetes. JAMA Network Open 2025, 8: e2454319. PMID: 39792382, PMCID: PMC11724344, DOI: 10.1001/jamanetworkopen.2024.54319.Peer-Reviewed Original ResearchConceptsRadon exposureGestational diabetesCohort studyPopulation-based cohort studyPregnant individualsMedical record abstractionNulliparous Pregnancy Outcomes StudyMultiple logistic regression modelsMonitoring Mothers-to-BeAssociated with greater oddsUS clinical centersMothers-to-beRadon exposure assessmentLogistic regression modelsEnvironmental risk factorsPregnancy Outcomes StudyStatistically significant interactionRecord abstractionImprove pregnancy outcomesMain OutcomesPM2.5 levelsHigher oddsPotential confoundersSmoking statusPregnant participants
2024
Association of gestational and childhood circulating C-peptide concentrations in the hyperglycemia and adverse pregnancy outcomes follow-up study
Rajamoorthi A, Zheng H, Skowronski A, Zork N, Reddy U, Tung P, Kupsco A, Gallagher D, Salem R, Leibel R, LeDuc C, Thaker V. Association of gestational and childhood circulating C-peptide concentrations in the hyperglycemia and adverse pregnancy outcomes follow-up study. Diabetes Research And Clinical Practice 2024, 220: 111967. PMID: 39716665, PMCID: PMC11840794, DOI: 10.1016/j.diabres.2024.111967.Peer-Reviewed Original ResearchConceptsOral glucose tolerance testC-peptide concentrationsC-peptideInsulin sensitivityCord bloodFollow-up studyInsulinogenic indexHOMA-IRCirculating C-peptide concentrationsCord blood C-peptideMaternal glucose concentrationsBlood C-peptideBMI z-scoreGlucose tolerance testPancreatic beta-cell developmentBeta-cell developmentGestational ageOGTT glucoseMaternal fastingAssociations of gestationalPubertal stageTolerance testInsulin resistanceZ-scoreMaternal covariatesThe association of higher offspring early‐childhood weight gain with prepregnancy metabolic and bariatric surgery
Hilaire M, Babcock A, White G, Masson C, Salem R, Reddy U, Gallagher D, LeDuc C, Thaker V. The association of higher offspring early‐childhood weight gain with prepregnancy metabolic and bariatric surgery. Obesity 2024, 32: 2012-2023. PMID: 39497631, PMCID: PMC11694145, DOI: 10.1002/oby.24166.Peer-Reviewed Original ResearchConceptsOffspring growth trajectoriesBariatric surgeryHypertensive disorders of pregnancyWorld Health Organization Child Growth StandardsRoux-en-Y gastric bypassWeight gainHigher BMI z-scoreEarly-life weight gainNon-MB groupDisorders of pregnancyGestational diabetes mellitusGestational weight gainLow birth weightBMI z-scoreChild Growth StandardsScore-matched controlsPrepregnancy BMIGestational outcomesHypertensive disordersSleeve gastrectomyGastric bypassBirth weightPrepregnancyDiabetes mellitusGrowth standardsDesign, rationale and protocol for Glycemic Observation and Metabolic Outcomes in Mothers and Offspring (GO MOMs): an observational cohort study
Group T, Scholtens D, LeBlanc E, Vesco K, Amy D, Bays K, Massimino S, Robinson S, Schell K, Walters G, Hillier T, Oshiro C, Cordero S, Howick C, Kim L, Martinez Y, Pishchalenko O, Wastlova V, Zork N, Mourad M, Lonier J, Reddy U, Acevedo J, Castillo J, Gomez M, Peguero B, Facco F, Feghali M, Bocan H, Stramowski S, Powe C, Edlow A, Barth W, Nathan D, Azevedo R, Baez A, Iroajanma C, Larkin M, Maya J, Michalopoulos C, Neamonitaki N, Thangthaeng N, Yee L, Lowe W, Grobman W, Szmuilowicz E, Aguirre A, Guevara E, Mallett G, Matos S, Tyagi S, Spadola A, Catalano P, Azimirad A, Werner E, Rouse D, Malloy M, Parra F, Sherr J, Merriam A, Bitterman S, Considine E, Leventhal J, Perley L, Rink L, Steffen A, Thompson B, Zgorski M, Steffes M, Arends V, Killeen A, Siddique J, Bustamante P, Cheung Y, Freeze C, Grott T, Kuang A, Tull M, Linder B. Design, rationale and protocol for Glycemic Observation and Metabolic Outcomes in Mothers and Offspring (GO MOMs): an observational cohort study. BMJ Open 2024, 14: e084216. PMID: 38851233, PMCID: PMC11163666, DOI: 10.1136/bmjopen-2024-084216.Peer-Reviewed Original ResearchConceptsLarge-for-gestational-age birth weightMetabolic outcomesLarge-for-gestational-ageDiagnosis of gestational diabetesOral glucose tolerance testAdverse pregnancy outcomesVanderbilt University Institutional Review BoardCourse of pregnancyObservational cohort studyGlucose tolerance testNational Institute of DiabetesDigestive and Kidney DiseasesGDM treatmentWeeks gestationDetect such abnormalitiesPerinatal outcomesGDM screeningInstitutional review boardGestational diabetesFirst-trimesterPregnancy outcomesEarly pregnancyGlucose abnormalitiesBirth weightPregnant adultsGenetic polymorphisms associated with adverse pregnancy outcomes in nulliparas
Khan R, Guerrero R, Wapner R, Hahn M, Raja A, Salleb-Aouissi A, Grobman W, Simhan H, Silver R, Chung J, Reddy U, Radivojac P, Pe’er I, Haas D. Genetic polymorphisms associated with adverse pregnancy outcomes in nulliparas. Scientific Reports 2024, 14: 10514. PMID: 38714721, PMCID: PMC11076516, DOI: 10.1038/s41598-024-61218-9.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesAdverse pregnancy outcomesMulti-ancestry genome-wide association studyCluster of SNPsGestational diabetesPregnancy outcomesAdmixed AmericansNovel lociPregnancy lossAssociation studiesGenetic markersIncreased risk of pregnancy lossTRMU geneGenetic ancestryAssociated with gestational diabetesRisk of pregnancy lossSub-cohortProportion of pregnanciesCause of morbidityLociAssociation TestSNPsPreterm birthMaternal riskIncreased riskAdverse Pregnancy Outcomes and Predicted 30-Year Risk of Maternal Cardiovascular Disease 2–7 Years After Delivery
Venkatesh K, Khan S, Yee L, Wu J, McNeil R, Greenland P, Chung J, Levine L, Simhan H, Catov J, Scifres C, Reddy U, Pemberton V, Saade G, Merz C, Grobman W, Mothers-to-Be A. Adverse Pregnancy Outcomes and Predicted 30-Year Risk of Maternal Cardiovascular Disease 2–7 Years After Delivery. Obstetrics And Gynecology 2024, 143: 775-784. PMID: 38574364, PMCID: PMC11098696, DOI: 10.1097/aog.0000000000005569.Peer-Reviewed Original ResearchConceptsRisk of atherosclerotic CVDAtherosclerotic CVD riskAdverse pregnancy outcomesHypertensive disorders of pregnancyAtherosclerotic CVDCVD riskDisorders of pregnancyPregnancy outcomesHypertensive disordersPreterm birthModified Poisson modelsFramingham risk scoreRisk of CVDRisk of atherosclerotic cardiovascular diseaseMagnitude of riskAbsolute riskAtherosclerotic cardiovascular diseaseSecondary analysisLongitudinal cohortRisk scoreGestational ageGreater riskBaseline covariatesCardiovascular diseaseDisease 2
2023
Researching COVID to enhance recovery (RECOVER) pregnancy study: Rationale, objectives and design
Metz T, Clifton R, Gallagher R, Gross R, Horwitz L, Jacoby V, Martin-Herz S, Peralta-Carcelen M, Reeder H, Beamon C, Chan J, Chang A, Costantine M, Fitzgerald M, Foulkes A, Gibson K, Güthe N, Habli M, Hackney D, Hoffman M, Hoffman M, Hughes B, Katz S, Laleau V, Mallett G, Mendez-Figueroa H, Monzon V, Palatnik A, Palomares K, Parry S, Pettker C, Plunkett B, Poppas A, Reddy U, Rouse D, Saade G, Sandoval G, Schlater S, Sciurba F, Simhan H, Skupski D, Sowles A, Thaweethai T, Thomas G, Thorp J, Tita A, Weiner S, Weigand S, Yee L, Flaherman V, Initiative O. Researching COVID to enhance recovery (RECOVER) pregnancy study: Rationale, objectives and design. PLOS ONE 2023, 18: e0285351. PMID: 38128008, PMCID: PMC10734909, DOI: 10.1371/journal.pone.0285351.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 infectionSARS-CoV-2Long-term outcomesMonths of agePregnancy cohortMaternal-Fetal Medicine Units NetworkHealth outcomesSARS-CoV-2 antibody testingAdverse long-term outcomesEunice Kennedy Shriver National InstitutePost-acute sequelaeLong-term sequelaeClinical trial registrationMaternal-child dyadsNational InstituteMulti-site observational studyCalifornia San FranciscoUnique physiologic changesPregnancy modifiesMaternal infectionMultiple gestationsOverall cohortRetrospective cohortAntibody testingLong COVIDCannabis Exposure and Adverse Pregnancy Outcomes Related to Placental Function
Metz T, Allshouse A, McMillin G, Greene T, Chung J, Grobman W, Haas D, Mercer B, Parry S, Reddy U, Saade G, Simhan H, Silver R. Cannabis Exposure and Adverse Pregnancy Outcomes Related to Placental Function. JAMA 2023, 330: 2191-2199. PMID: 38085313, PMCID: PMC10716715, DOI: 10.1001/jama.2023.21146.Peer-Reviewed Original ResearchConceptsPrimary composite outcomeAdverse pregnancy outcomesComposite outcomeFirst trimesterCannabis exposurePregnancy outcomesCannabis usePlacental functionPropensity score-weighted analysisNulliparous Pregnancy Outcomes StudyOngoing exposureMaternal cannabis useUrine cotinine assayUrine samplesMedical record abstractionPregnancy outcome dataGestational-age birthsBody mass indexGestational age windowsPregnancy Outcomes StudyUS medical centersOngoing cannabis useAdjudication of outcomesMaternal cannabisHypertensive disordersRandomized Trial of Hyperimmune Globulin for Congenital CMV Infection — 2-Year Outcomes
Hughes B, Clifton R, Rouse D, Saade G, Dinsmoor M, Reddy U, Pass R, Allard D, Mallett G, MacPherson C, Wapner R, Metz T, Goodnight W, Tita A, Costantine M, Swamy G, Heyborne K, Chien E, Chauhan S, El-Sayed Y, Casey B, Parry S, Simhan H, Napolitano P, Macones G. Randomized Trial of Hyperimmune Globulin for Congenital CMV Infection — 2-Year Outcomes. New England Journal Of Medicine 2023, 389: 1822-1824. PMID: 37937785, PMCID: PMC10683876, DOI: 10.1056/nejmc2308286.Peer-Reviewed Original ResearchContinuous non-invasive hemodynamic monitoring in early onset severe preeclampsia
Ackerman-Banks C, Bhinder J, Eder M, Heerdt P, Sugeng L, Testani J, Alian A, Lipkind H, Velazquez E, Reddy U, Chou J. Continuous non-invasive hemodynamic monitoring in early onset severe preeclampsia. Pregnancy Hypertension 2023, 34: 27-32. PMID: 37783090, DOI: 10.1016/j.preghy.2023.09.003.Peer-Reviewed Original ResearchConceptsTotal peripheral resistanceCardiac outputSevere preeclampsiaHemodynamic monitoringEarly-onset severe preeclampsiaProspective observational studyOnset severe preeclampsiaContinuous hemodynamic monitoringNon-invasive hemodynamic monitoringEarly preeclampsiaPregnant patientsPeripheral resistanceObservational studyPreeclampsiaLow mean biasDays postpartumNICOMModerate correlationPoor correlationMean biasAntepartumPatientsSodium intake and the development of hypertensive disorders of pregnancy
Bank T, Grasch J, Chung J, Mercer B, McNeil R, Parry S, Saade G, Shanks A, Silver R, Simhan H, Yee L, Reddy U, Grobman W, Frey H. Sodium intake and the development of hypertensive disorders of pregnancy. American Journal Of Obstetrics & Gynecology MFM 2023, 5: 101166. PMID: 37741626, DOI: 10.1016/j.ajogmf.2023.101166.Peer-Reviewed Original ResearchConceptsHypertensive disordersHigh sodium intakeSodium intakeChronic hypertensionNonpregnant populationLow platelet count syndromeNeonatal intensive care unitNulliparous Pregnancy Outcomes StudyElevated liver enzymesGestational age neonatesFood frequency questionnaireLow sodium intakeIncidence risk ratioIntensive care unitWeeks of gestationPregnancy Outcomes StudyLack of associationChi-square testGestational hypertensionNeonatal outcomesNonpregnant stateSodium restrictionFrequency questionnairePreterm birthSingleton pregnanciesRisk Factors for Perinatal Transmission of Hepatitis C Virus
Prasad M, Saade G, Clifton R, Sandoval G, Hughes B, Reddy U, Bartholomew A, Salazar A, Chien E, Tita A, Thorp J, Metz T, Wapner R, Sabharwal V, Simhan H, Swamy G, Heyborne K, Sibai B, Grobman W, El-Sayed Y, Casey B, Parry S, Rathore M, Diaz-Velasco R, Puga A, Wiznia A, Kovacs A, Garry D, Macones G. Risk Factors for Perinatal Transmission of Hepatitis C Virus. Obstetrics And Gynecology 2023, 142: 449-456. PMID: 37590978, PMCID: PMC10437102, DOI: 10.1097/aog.0000000000005306.Peer-Reviewed Original ResearchConceptsPerinatal transmissionHCV infectionRisk factorsPrimary outcomeHuman Development Maternal-Fetal Medicine Units NetworkMaternal-Fetal Medicine Units NetworkHepatitis C virus infectionEunice Kennedy Shriver National InstituteC virus infectionPerinatal transmission rateWeeks of gestationHigh viral loadHepatitis C virusMonths of lifePositive test resultsAntepartum bleedingViremic participantsVaginal bleedingHCV RNAViremic individualsViral loadC virusObservational studyVirus infectionDemonstrable viremiaSearching and visualizing genetic associations of pregnancy traits by using GnuMoM2b
Yan Q, Guerrero R, Khan R, Surujnarine A, Wapner R, Hahn M, Raja A, Salleb-Aouissi A, Grobman W, Simhan H, Blue N, Silver R, Chung J, Reddy U, Radivojac P, Pe’er I, Haas D. Searching and visualizing genetic associations of pregnancy traits by using GnuMoM2b. Genetics 2023, 225: iyad151. PMID: 37602697, PMCID: PMC10691790, DOI: 10.1093/genetics/iyad151.Peer-Reviewed Original ResearchConceptsAdverse pregnancy outcomesNulliparous Pregnancy Outcomes StudyPregnancy Outcomes StudyMajor risk factorGenome-wide association studiesPregnancy outcomesGenetic associationMonitoring MothersRisk factorsOutcome studiesWomen's healthPhenome-wide association studySingle nucleotide polymorphismsAssociation studiesGenetic resultsPregnancyNucleotide polymorphismsAssessing Intrauterine Retention according to Microscopic Stillbirth Features: A Cluster Analysis Approach
Cersonsky T, Saade G, Silver R, Reddy U, Dudley D, Pinar H. Assessing Intrauterine Retention according to Microscopic Stillbirth Features: A Cluster Analysis Approach. Fetal And Pediatric Pathology 2023, 42: 860-869. PMID: 37571967, PMCID: PMC10843727, DOI: 10.1080/15513815.2023.2246571.Peer-Reviewed Original ResearchMacroscopic lesions of maternal and fetal vascular malperfusion in stillborn placentas: Diagnosis in the absence of microscopic histopathological examination
Cersonsky T, Silver R, Saade G, Dudley D, Reddy U, Pinar H. Macroscopic lesions of maternal and fetal vascular malperfusion in stillborn placentas: Diagnosis in the absence of microscopic histopathological examination. Placenta 2023, 140: 60-65. PMID: 37536149, PMCID: PMC10530266, DOI: 10.1016/j.placenta.2023.07.296.Peer-Reviewed Original ResearchConceptsFetal vascular malperfusionMaternal vascular malperfusionVascular malperfusionLive birthsFVM lesionsGestational ageMacroscopic findingsAmsterdam Placental Workshop Group Consensus StatementStillbirth Collaborative Research NetworkMicroscopic histopathological examinationMicroscopic pathologic evaluationHistory of hypertensionOdds of stillbirthGroup Consensus StatementMultivariate logistic regressionMVM lesionsPathologic evaluationHistopathological examinationMaternal raceOdds ratioConsensus statementHigher oddsUmbilical cordStillbirthMaternal factorsCervical Pessary for Prevention of Preterm Birth in Individuals With a Short Cervix
Hoffman M, Clifton R, Biggio J, Saade G, Ugwu L, Longo M, Bousleiman S, Clark K, Grobman W, Frey H, Chauhan S, Dugoff L, Manuck T, Chien E, Rouse D, Simhan H, Esplin M, Macones G, Bickus M, Facco F, Tita A, Grant J, Casey B, Harris S, Harper L, Dunn D, Longo S, Hendricks M, Lata-Arias K, Costantine M, Bartholomew A, Cline D, Harper S, Ward C, Gardner N, Brindle S, Weigand S, McKenna D, Snow E, Fennig K, Habli M, Lambers D, McClellan M, Metz T, Sowles A, Varner M, Hill K, Morby V, Meadows C, Allard D, Werner E, Rousseau J, Milano J, Pettker C, Leventhal J, Gyamfi-Bannerman C, Wapner R, Carmona V, Firman B, Vanneman A, Palomares K, Beche I, Skupski D, Chan-Akeley R, Salazar A, Pacheco L, McCoy L, Saad A, Jain S, Omere C, Clifford C, McDonnold M, Chien E, Dalton W, Polito L, Milluzi C, Kushner K, Maile A, Bell J, Hackney D, Ortiz F, Timlin S, Goodnight W, Manuck T, Beamon C, Nun H, Eichelberger K, Moore A, Hughes B, Ferrara J, Grobman W, Mallett G, Stein L, Miller E, Plunkett B, Kearns K, Palatnik A, Malone T, Parry S, Pizzi C, Craig J, Filipczak A, Thom E, Doherty L, Hubbard A, Erikson P, Pinto T, Marcharchand P, Reddy U, Miodovnik M, Archer S. Cervical Pessary for Prevention of Preterm Birth in Individuals With a Short Cervix. JAMA 2023, 330: 340-348. PMID: 37490086, PMCID: PMC10369212, DOI: 10.1001/jama.2023.10812.Peer-Reviewed Original ResearchConceptsCervical pessaryUsual carePreterm birthShort cervixVaginal progesteroneCervical lengthSingleton pregnanciesFetal deathPrimary outcomeInfant deathPrior spontaneous preterm birthTransvaginal ultrasound cervical lengthCervical pessary placementWeeks 0 daysSpontaneous preterm birthUltrasound cervical lengthWeeks 6 daysThird interim analysisNeonatal/infant mortalityPreterm deliverySingleton gestationsBaseline characteristicsUltrasound evidencePessary placementTransvaginal ultrasoundGroup B streptococcus colonization in pregnancy and neighborhood socioeconomic disadvantage
Bank T, Yee L, Lynch C, Wu J, Johnson J, McNeil R, Mercer B, Simhan H, Reddy U, Silver R, Parry S, Saade G, Chung J, Wapner R, Grobman W, Venkatesh K. Group B streptococcus colonization in pregnancy and neighborhood socioeconomic disadvantage. American Journal Of Obstetrics And Gynecology 2023, 229: 564-566.e7. PMID: 37487854, DOI: 10.1016/j.ajog.2023.07.028.Peer-Reviewed Original Research
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply