2023
Randomized Trial of Hyperimmune Globulin for Congenital CMV Infection — 2-Year Outcomes
Hughes B, Clifton R, Rouse D, Saade G, Dinsmoor M, Reddy U, Pass R, Allard D, Mallett G, MacPherson C, Wapner R, Metz T, Goodnight W, Tita A, Costantine M, Swamy G, Heyborne K, Chien E, Chauhan S, El-Sayed Y, Casey B, Parry S, Simhan H, Napolitano P, Macones G. Randomized Trial of Hyperimmune Globulin for Congenital CMV Infection — 2-Year Outcomes. New England Journal Of Medicine 2023, 389: 1822-1824. PMID: 37937785, PMCID: PMC10683876, DOI: 10.1056/nejmc2308286.Peer-Reviewed Original ResearchHypertension in Pregnancy and Adverse Outcomes Among Low-risk Nulliparous Women Expectantly Managed at or After 39 weeks: A Secondary Analysis of a Randomized Controlled Trial
Bartal M, Premkumar A, Rice M, Reddy U, Tita A, Silver R, El-Sayed Y, Wapner R, Rouse D, Saade G, Thorp J, Constantine M, Chien E, Casey B, Srinivas S, Swamy G, Simhan H. Hypertension in Pregnancy and Adverse Outcomes Among Low-risk Nulliparous Women Expectantly Managed at or After 39 weeks: A Secondary Analysis of a Randomized Controlled Trial. Obstetric Anesthesia Digest 2023, 43: 82-82. DOI: 10.1097/01.aoa.0000927856.60760.92.Peer-Reviewed Original ResearchLow-risk patientsLow-risk nulliparous womenHypertensive disordersMaternal morbidityMaternal outcomesNulliparous womenControlled TrialsWeeks' gestationAdverse outcomesLower riskSecondary analysisPregnancyPatientsHDPOutcomesRecent studiesHypertensionMorbidityGestationMortalityPrevalenceTrialsWeeksWomen
2022
Treatment for Mild Chronic Hypertension During Pregnancy
Tita A, Szychowski J, Boggess K, Dugoff L, Sibai B, Lawrence K, Hughes B, Bell J, Aagaard K, Edwards R, Gibson K, Haas D, Plante L, Metz T, Casey B, Esplin S, Longo S, Hoffman M, Saade G, Hoppe K, Foroutan J, Tuuli M, Owens M, Simhan H, Frey H, Rosen T, Palatnik A, Baker S, August P, Reddy U, Kinzler W, Su E, Krishna I, Nguyen N, Norton M, Skupski D, El-Sayed Y, Ogunyemi D, Galis Z, Harper L, Ambalavanan N, Geller N, Oparil S, Cutter G, Andrews W. Treatment for Mild Chronic Hypertension During Pregnancy. Obstetrical & Gynecological Survey 2022, 77: 634-636. DOI: 10.1097/01.ogx.0000899456.24100.71.Peer-Reviewed Original ResearchHypertension During PregnancyAcute kidney injuryAdverse neonatal outcomesChronic hypertensionKidney injuryMaternal outcomesNeonatal outcomesPlacental abruptionPreterm birthHeart failureMaternal deathsGestational agePerinatal deathPulmonary edemaPregnancyBlack womenDeathOutcomesHypertensionAbruptionPreeclampsiaEdemaInjuryStrokeWomenTreatment for Mild Chronic Hypertension During Pregnancy
Tita A, Szychowski J, Boggess K, Dugoff L, Sibai B, Lawrence K, Hughes B, Bell J, Aagaard K, Edwards R, Gibson K, Haas D, Plante L, Metz T, Casey B, Esplin S, Longo S, Hoffman M, Saade G, Hoppe K, Foroutan J, Tuuli M, Owens M, Simhan H, Frey H, Rosen T, Palatnik A, Baker S, August P, Reddy U, Kinzler W, Su E, Krishna I, Nguyen N, Norton M, Skupski D, El-Sayed Y, Ogunyemi D, Galis Z, Harper L, Ambalavanan N, Geller N, Oparil S, Cutter G, Andrews W. Treatment for Mild Chronic Hypertension During Pregnancy. Obstetrical & Gynecological Survey 2022, 77: 460-462. DOI: 10.1097/01.ogx.0000852888.79526.c3.Peer-Reviewed Original ResearchPericonceptional diet quality predicts glycemic control and gestational diabetes risk in nulliparous women
Milone G, Chung J, Haas D, Silver R, Grobman W, Simhan H, Saade G, Reddy U, Lindsay K. Periconceptional diet quality predicts glycemic control and gestational diabetes risk in nulliparous women. American Journal Of Obstetrics And Gynecology 2022, 226: s46-s47. DOI: 10.1016/j.ajog.2021.11.106.Peer-Reviewed Original ResearchA Trial of Hyperimmune Globulin to Prevent Congenital Cytomegalovirus Infection
Hughes B, Clifton R, Rouse D, Saade G, Dinsmoor M, Reddy U, Pass R, Allard D, Mallett G, Fette L, Gyamfi-Bannerman C, Varner M, Goodnight W, Tita A, Costantine M, Swamy G, Gibbs R, Chien E, Chauhan S, El-Sayed Y, Casey B, Parry S, Simhan H, Napolitano P, Macones G. A Trial of Hyperimmune Globulin to Prevent Congenital Cytomegalovirus Infection. Obstetrical & Gynecological Survey 2022, 77: 16-18. DOI: 10.1097/01.ogx.0000805168.83387.d5.Peer-Reviewed Original Research
2021
Maternal serum fructosamine levels and stillbirth: a case–control study of the Stillbirth Collaborative Research Network
Arslan E, Allshouse A, Page J, Varner M, Thorsten V, Parker C, Dudley D, Saade G, Goldenberg R, Stoll B, Hogue C, Bukowski R, Conway D, Pinar H, Reddy U, Silver R. Maternal serum fructosamine levels and stillbirth: a case–control study of the Stillbirth Collaborative Research Network. BJOG An International Journal Of Obstetrics & Gynaecology 2021, 129: 619-626. PMID: 34529344, DOI: 10.1111/1471-0528.16922.Peer-Reviewed Original ResearchConceptsSerum fructosamine levelsFructosamine levelsCase-control studyTime of deliveryLive birthsStillbirth Collaborative Research NetworkLive birth controlsCases of stillbirthPotential confounding factorsGeographic catchment areaSingleton stillbirthsGlycaemic controlDiabetes statusMulticentre studyRoutine screeningFructosamine measurementsDiabetesStillbirthConfounding factorsSecondary analysisWomenBirthCollaborative research networksBirth controlResearch NetworkHealth Resource Utilization of Labor Induction Versus Expectant Management
Grobman W, Sandoval G, Reddy U, Tita A, Silver R, Mallett G, Hill K, Rice M, El-Sayed Y, Wapner R, Rouse D, Saade G, Thorp J, Chauhan S, Iams J, Chien E, Casey B, Gibbs R, Srinivas S, Swamy G, Simhan H, Macones G. Health Resource Utilization of Labor Induction Versus Expectant Management. Obstetric Anesthesia Digest 2021, 41: 34-34. DOI: 10.1097/01.aoa.0000732480.32100.cf.Peer-Reviewed Original ResearchExpectant managementElective inductionNulliparous womenLow-risk nulliparous womenHealth care resource utilizationHealth resource utilizationNeonatal respiratory morbidityElective labor inductionARRIVE trialDelivery admissionHypertensive disordersCesarean deliveryLabor inductionRespiratory morbidityWeeks postpartumTrialsManagement trialsWeeksWomenInductionCurrent studyResource utilizationAntepartumMorbidityPregnancy726 Fetal growth by ultrasound prior to the diagnosis of gestational diabetes mellitus in nulliparous women
Mahdasian-Miller A, Scifres C, Haas D, Grobman W, Silver R, Wing D, Saade G, Reddy U, Simhan H. 726 Fetal growth by ultrasound prior to the diagnosis of gestational diabetes mellitus in nulliparous women. American Journal Of Obstetrics And Gynecology 2021, 224: s455-s456. DOI: 10.1016/j.ajog.2020.12.749.Peer-Reviewed Original Research
2020
938: Yale Hearts Moms Study: Cardiovascular screening in women with pregnancy hypertension 6-12 months after delivery
Lipkind H, Ackerman C, Grechukhina O, Chou J, Spatz E, O'Bryan J, Smith S, Gaeta M, Perley L, Reddy U, Smith G. 938: Yale Hearts Moms Study: Cardiovascular screening in women with pregnancy hypertension 6-12 months after delivery. American Journal Of Obstetrics And Gynecology 2020, 222: s581. DOI: 10.1016/j.ajog.2019.11.949.Peer-Reviewed Original Research
2019
Duration of Operative Vaginal Delivery and Adverse Obstetric Outcomes
Miller E, Lai Y, Bailit J, Reddy U, Wapner R, Varner M, Thorp J, Leveno K, Caritis S, Prasad M, Tita A, Saade G, Sorokin Y, Rouse D, Blackwell S, Tolosa J. Duration of Operative Vaginal Delivery and Adverse Obstetric Outcomes. American Journal Of Perinatology 2019, 37: 503-510. PMID: 30895577, PMCID: PMC6754310, DOI: 10.1055/s-0039-1683439.Peer-Reviewed Original ResearchConceptsComposite adverse neonatal outcomeAdverse neonatal outcomesOperative vaginal deliveryNeonatal outcomesVaginal deliveryMulticenter observational cohortAdverse obstetric outcomesSevere perineal lacerationsObstetric outcomesPerinatal outcomesObservational cohortPerineal lacerationsPrimary cohortForceps applicationPotential confoundersSecondary analysisStrong associationOutcomesWomenCohortDurationDeliveryLacerationConfoundersForcepsPredictors of Sleep-disordered Breathing in Pregnancy
Louis J, Koch M, Reddy U, Silver R, Parker C, Facco F, Redline S, Nhan-Chang C, Chung J, Pien G, Basner R, Grobman W, Wing D, Simhan H, Haas D, Mercer B, Parry S, Mobley D, Carper B, Saade G, Schubert F, Zee P. Predictors of Sleep-disordered Breathing in Pregnancy. Obstetric Anesthesia Digest 2019, 39: 36-37. DOI: 10.1097/01.aoa.0000552909.82459.b1.Peer-Reviewed Original ResearchSleep-disordered breathingDiagnosis of SDBSevere maternal morbidityRisk of complicationsMaternal morbidityPreterm deliverySDB symptomsVenous thromboembolismMaternal deathsOvernight polysomnographyPregnant womenAdverse outcomesLarge cohortFeasible prediction modelPregnancyBreathingWomenThromboembolismPreeclampsiaMorbidityComplicationsPolysomnographyCohortSymptomsDiagnosisLabor Induction Versus Expectant Management in Low-Risk Nulliparous Women
Grobman W, Rice M, Reddy U, Tita A, Silver R, Mallett G, Hill K, Thom E, El-Sayed Y, Perez-Delboy A, Rouse D, Saade G, Boggess K, Chauhan S, Iams J, Chien E, Casey B, Gibbs R, Srinivas S, Swamy G, Simhan H, Macones G. Labor Induction Versus Expectant Management in Low-Risk Nulliparous Women. Obstetrical & Gynecological Survey 2019, 74: 7-9. DOI: 10.1097/01.ogx.0000550506.01685.a7.Peer-Reviewed Original Research
2018
Defining Failed Induction of Labor
Grobman W, Bailit J, Lai Y, Reddy U, Wapner R, Varner M, Thorp J, Leveno K, Caritis S, Prasad M, Tita A, Saade G, Sorokin Y, Rouse D, Blackwell S, Tolosa J. Defining Failed Induction of Labor. Obstetric Anesthesia Digest 2018, 38: 215. DOI: 10.1097/01.aoa.0000547313.79293.f8.Peer-Reviewed Original ResearchCervical funneling or intra‐amniotic debris and preterm birth in nulliparous women with midtrimester cervical length less than 30 mm
Saade G, Thom E, Grobman W, Iams J, Mercer B, Reddy U, Tita A, Rouse D, Sorokin Y, Wapner R, Leveno K, Blackwell S, Esplin M, Tolosa J, Thorp J, Caritis S, Vandorsten J, Network T. Cervical funneling or intra‐amniotic debris and preterm birth in nulliparous women with midtrimester cervical length less than 30 mm. Ultrasound In Obstetrics And Gynecology 2018, 52: 757-762. PMID: 29155504, PMCID: PMC5960623, DOI: 10.1002/uog.18960.Peer-Reviewed Original ResearchConceptsCervical funnelingMidtrimester cervical lengthCervical lengthPreterm birthWeeks' gestationNulliparous womenMedian cervical lengthSecondary cohort analysisNulliparous pregnant womenSecond trimester ultrasoundAsymptomatic nulliparous womenMultivariable adjustmentSingleton gestationsMulticenter trialMultivariable analysisTransvaginal ultrasoundSecond trimesterPregnant womenCohort analysisGestationWomenHigh rateWeeksUltrasoundLtNonmedically Indicated Induction in Morbidly Obese Women is Not Associated With an Increased Risk of Cesarean Delivery
Kawakita T, Iqbal S, Huang C, Reddy U. Nonmedically Indicated Induction in Morbidly Obese Women is Not Associated With an Increased Risk of Cesarean Delivery. Obstetric Anesthesia Digest 2018, 38: 125-126. DOI: 10.1097/01.aoa.0000542343.43890.b0.Peer-Reviewed Original ResearchInduction of laborMorbidly obese womenCesarean deliveryObese womenExpectant managementClass III obesityRetrospective cohort studyNormal-weight womenIndicated inductionMaternal comorbiditiesMorbid obesityNeonatal outcomesCohort studySecondary outcomesWeeks' gestationRisk factorsHigh prevalenceClass IIObesityWomenComorbiditiesInductionOutcomesDeliveryRiskReassessing the Duration of the Second Stage of Labor in Relation to Maternal and Neonatal Morbidity
Grantz K, Sundaram R, Ma L, Hinkle S, Berghella V, Hoffman M, Reddy U. Reassessing the Duration of the Second Stage of Labor in Relation to Maternal and Neonatal Morbidity. Obstetric Anesthesia Digest 2018, 38: 71. DOI: 10.1097/01.aoa.0000532263.77010.0d.Peer-Reviewed Original ResearchNeonatal morbidityInitial cesarean sectionMaternal febrile morbiditySecond-stage arrestMaternal-fetal medicineFebrile morbidityEpidural analgesiaCesarean sectionMultiparous womenNulliparous womenPostpartum hemorrhageVaginal birthAmerican CollegeMorbidityMortalityWomenPresent studyBirthHoursAnalgesiaEpiduralHemorrhagePatientsGynecologistsObstetriciansReassessing the Duration of the Second Stage of Labor in Relation to Maternal and Neonatal Morbidity
Grantz KL, Sundaram R, Ma L, Hinkle S, Berghella V, Hoffman MK, Reddy UM. Reassessing the Duration of the Second Stage of Labor in Relation to Maternal and Neonatal Morbidity. Obstetrics And Gynecology 2018, 131: 345-353. PMID: 29324600, PMCID: PMC5785437, DOI: 10.1097/aog.0000000000002431.Peer-Reviewed Original ResearchConceptsSpontaneous vaginal birthSecond stage durationVaginal birthNulliparous womenNeonatal complicationsNeonatal morbidityCesarean deliveryFetal heart rate tracingsFirst half hourPrior cesarean deliverySpontaneous vaginal deliveryWeeks of gestationHeart rate tracingsVertex birthsRetrospective cohortMultiparous womenSerious complicationsSerious morbidityVaginal deliveryMorbidityHalf hourLikelihood of birthComplicationsWomenBirth
2017
Opioid Use in Pregnancy, Neonatal Abstinence Syndrome, and Childhood Outcomes
Reddy U, Davis J, Ren Z, Greene M. Opioid Use in Pregnancy, Neonatal Abstinence Syndrome, and Childhood Outcomes. Obstetrical & Gynecological Survey 2017, 72: 703-705. DOI: 10.1097/ogx.0000000000000517.Peer-Reviewed Original ResearchNeonatal abstinence syndromeOpioid useAbstinence syndromeChildhood outcomesEunice Kennedy Shriver National InstituteOpioid use disorderMaternal-fetal medicineMarch of DimesAffected womenAmerican CollegeChild healthUse disordersAmerican AcademyDisease controlPregnancyNational InstituteSyndromeOutcomesGynecologistsObstetriciansPediatricsPreventionWomenPredictive Accuracy of Serial Transvaginal Cervical Lengths and Quantitative Vaginal Fetal Fibronectin Levels for Spontaneous Preterm Birth Among Nulliparous Women
Esplin M, Elovitz M, Iams J, Parker C, Wapner R, Grobman W, Simhan H, Wing D, Haas D, Silver R, Hoffman M, Peaceman A, Caritis S, Parry S, Wadhwa P, Foroud T, Mercer B, Hunter S, Saade G, Reddy U. Predictive Accuracy of Serial Transvaginal Cervical Lengths and Quantitative Vaginal Fetal Fibronectin Levels for Spontaneous Preterm Birth Among Nulliparous Women. Obstetrical & Gynecological Survey 2017, 72: 397-399. DOI: 10.1097/ogx.0000000000000455.Peer-Reviewed Original Research