2024
Stillbirth: we can do better
Silver R, Reddy U. Stillbirth: we can do better. American Journal Of Obstetrics And Gynecology 2024, 231: 152-165. PMID: 38789073, DOI: 10.1016/j.ajog.2024.05.042.Peer-Reviewed Original ResearchResource countriesNon-Hispanic blacksPrevention of stillbirthNon-Hispanic whitesOther Pacific IslanderRate of stillbirthLow-income countriesStillbirth rateStillbirthRisk factorsPacific IslandersGenetic etiologyPlacental assessmentEmotion managementRisk stratificationPreventionUnited StatesPregnancyRiskDisparitiesEpidemiologyCountriesU.S.White
2023
Macroscopic lesions of maternal and fetal vascular malperfusion in stillborn placentas: Diagnosis in the absence of microscopic histopathological examination
Cersonsky T, Silver R, Saade G, Dudley D, Reddy U, Pinar H. Macroscopic lesions of maternal and fetal vascular malperfusion in stillborn placentas: Diagnosis in the absence of microscopic histopathological examination. Placenta 2023, 140: 60-65. PMID: 37536149, PMCID: PMC10530266, DOI: 10.1016/j.placenta.2023.07.296.Peer-Reviewed Original ResearchConceptsFetal vascular malperfusionMaternal vascular malperfusionVascular malperfusionLive birthsFVM lesionsGestational ageMacroscopic findingsAmsterdam Placental Workshop Group Consensus StatementStillbirth Collaborative Research NetworkMicroscopic histopathological examinationMicroscopic pathologic evaluationHistory of hypertensionOdds of stillbirthGroup Consensus StatementMultivariate logistic regressionMVM lesionsPathologic evaluationHistopathological examinationMaternal raceOdds ratioConsensus statementHigher oddsUmbilical cordStillbirthMaternal factorsPlacental lesions associated with stillbirth by gestational age, according to feature importance: Results from the stillbirth collaborative research network
Cersonsky T, Cersonsky R, Saade G, Silver R, Reddy U, Goldenberg R, Dudley D, Pinar H. Placental lesions associated with stillbirth by gestational age, according to feature importance: Results from the stillbirth collaborative research network. Placenta 2023, 137: 59-64. PMID: 37080046, PMCID: PMC10192128, DOI: 10.1016/j.placenta.2023.04.005.Peer-Reviewed Original ResearchConceptsStillbirth Collaborative Research NetworkGestational agePlacental lesionsDifferent gestational agesCollaborative research networksResearch NetworkTerm stillbirthFetal mortalityPlacental featuresHistologic changesStillbirthLesionsWeeksStandard protocolPlacentaFurther investigationAgePrincipal covariatesPrevious studiesGestationMortality
2022
Copy number variants and fetal growth in stillbirths
Dalton S, Workalemahu T, Allshouse A, Page J, Reddy U, Saade G, Pinar H, Goldenberg R, Dudley D, Silver R. Copy number variants and fetal growth in stillbirths. American Journal Of Obstetrics And Gynecology 2022, 228: 579.e1-579.e11. PMID: 36356697, PMCID: PMC10149588, DOI: 10.1016/j.ajog.2022.11.1274.Peer-Reviewed Original ResearchConceptsAbnormal copy number variantsFetal growth abnormalitiesGestational ageOdds ratioStillbirth Collaborative Research NetworkGenetic abnormalitiesChromosomal microarrayGestational age outcomesGestational age infantsGrowth abnormalitiesClinical risk factorsCohort study designAdjusted odds ratioCopy number variantsUnknown clinical significancePathogenic copy number variantsPlacental insufficiencyAge infantsNumber variantsFetal growthMaternal ageRisk factorsClinical significanceHigh incidenceStillbirthFetal Death
Oliver E, Reddy U. Fetal Death. 2022, 564-571. DOI: 10.1201/9781003099062-57.Peer-Reviewed Original ResearchA Trial of Hyperimmune Globulin to Prevent Congenital Cytomegalovirus Infection
Hughes B, Clifton R, Rouse D, Saade G, Dinsmoor M, Reddy U, Pass R, Allard D, Mallett G, Fette L, Gyamfi-Bannerman C, Varner M, Goodnight W, Tita A, Costantine M, Swamy G, Gibbs R, Chien E, Chauhan S, El-Sayed Y, Casey B, Parry S, Simhan H, Napolitano P, Macones G. A Trial of Hyperimmune Globulin to Prevent Congenital Cytomegalovirus Infection. Obstetrical & Gynecological Survey 2022, 77: 16-18. DOI: 10.1097/01.ogx.0000805168.83387.d5.Peer-Reviewed Original Research
2021
Maternal serum fructosamine levels and stillbirth: a case–control study of the Stillbirth Collaborative Research Network
Arslan E, Allshouse A, Page J, Varner M, Thorsten V, Parker C, Dudley D, Saade G, Goldenberg R, Stoll B, Hogue C, Bukowski R, Conway D, Pinar H, Reddy U, Silver R. Maternal serum fructosamine levels and stillbirth: a case–control study of the Stillbirth Collaborative Research Network. BJOG An International Journal Of Obstetrics & Gynaecology 2021, 129: 619-626. PMID: 34529344, DOI: 10.1111/1471-0528.16922.Peer-Reviewed Original ResearchConceptsSerum fructosamine levelsFructosamine levelsCase-control studyTime of deliveryLive birthsStillbirth Collaborative Research NetworkLive birth controlsCases of stillbirthPotential confounding factorsGeographic catchment areaSingleton stillbirthsGlycaemic controlDiabetes statusMulticentre studyRoutine screeningFructosamine measurementsDiabetesStillbirthConfounding factorsSecondary analysisWomenBirthCollaborative research networksBirth controlResearch NetworkCausal Genetic Variants in Stillbirth
Stanley K, Giordano J, Thorsten V, Buchovecky C, Thomas A, Ganapathi M, Liao J, Dharmadhikari A, Revah‐Politi A, Ernst M, Lippa N, Holmes H, Povysil G, Hostyk J, Parker C, Goldenberg R, Saade G, Dudley D, Pinar H, Hogue C, Reddy U, Silver R, Aggarwal V, Allen A, Wapner R, Goldstein D. Causal Genetic Variants in Stillbirth. Obstetric Anesthesia Digest 2021, 41: 42-42. DOI: 10.1097/01.aoa.0000732532.96202.8a.Peer-Reviewed Original ResearchCasual Genetic Variants in Stillbirth
Stanley K, Giordano J, Thorsten V, Buchovecky C, Thomas A, Ganapathi M, Liao J, Dharmadhikari A, Revah-Politi A, Ernst M, Lippa N, Holmes H, Povysil G, Hostyk J, Parker C, Goldenberg R, Saade G, Dudley D, Pinar H, Hogue C, Reddy U, Silver R, Aggarwal V, Allen A, Wapner R, Goldstein D. Casual Genetic Variants in Stillbirth. Obstetrical & Gynecological Survey 2021, 76: 79-81. DOI: 10.1097/01.ogx.0000733520.96334.74.Peer-Reviewed Original Research
2020
Umbilical Cord Abnormalities and Stillbirth
Hammad I, Blue N, Allshouse A, Silver R, Gibbins K, Page J, Goldenberg R, Reddy U, Saade G, Dudley D, Thorsten V, Conway D, Pinar H, Pysher T. Umbilical Cord Abnormalities and Stillbirth. Obstetric Anesthesia Digest 2020, 40: 200-200. DOI: 10.1097/01.aoa.0000719564.10175.ff.Peer-Reviewed Original ResearchProspective Evaluation of Maternal Sleep Position Through 30 Weeks of Gestation and Adverse Pregnancy Outcomes
Silver R, Hunter S, Reddy U, Facco F, Gibbins K, Grobman W, Mercer B, Haas D, Simhan H, Parry S, Wapner R, Louis J, Chung J, Pien G, Schubert F, Saade G, Zee P, Redline S, Parker C. Prospective Evaluation of Maternal Sleep Position Through 30 Weeks of Gestation and Adverse Pregnancy Outcomes. Obstetrical & Gynecological Survey 2020, 75: 139-141. DOI: 10.1097/ogx.0000000000000782.Peer-Reviewed Original Research161: Risk factors for Recurrent Stillbirth (SB): Results from the Stillbirth Collaborative Research Network (SCRN)
Whitham M, Gammon E, Chronister B, Urban A, Silver R, Reddy U, Dudley D. 161: Risk factors for Recurrent Stillbirth (SB): Results from the Stillbirth Collaborative Research Network (SCRN). American Journal Of Obstetrics And Gynecology 2020, 222: s116-s117. DOI: 10.1016/j.ajog.2019.11.177.Peer-Reviewed Original Research
2018
Smith–Lemli–Opitz Mutations in Unexplained Stillbirths
Gibbins KJ, Reddy UM, Saade GR, Goldenberg RL, Dudley DJ, Parker CB, Thorsten V, Pinar H, Bukowski R, Hogue CJ, Silver RM. Smith–Lemli–Opitz Mutations in Unexplained Stillbirths. American Journal Of Perinatology 2018, 35: 936-939. PMID: 29433144, PMCID: PMC6060008, DOI: 10.1055/s-0038-1626705.Peer-Reviewed Original ResearchConceptsUnexplained stillbirthLive birthsPopulation-based case-control studyCase-control studySmith-LemliAutosomal recessive syndromeObstetric complicationsHistologic featuresExon 3Placental tissueStillbirthRecessive syndromeDeoxyribonucleic acidStrong associationBidirectional sequencingDHCR7 mutationsCompound heterozygotesSyndromeCholesterol biosynthesisOpitz syndromeHomozygote frequencyBirthRepresentative sampleSLOS mutationsDHCR7Potentially Preventable Stillbirth in a Diverse U.S. Cohort
Page JM, Thorsten V, Reddy UM, Dudley DJ, Hogue CJR, Saade GR, Pinar H, Parker CB, Conway D, Stoll BJ, Coustan D, Bukowski R, Varner MW, Goldenberg RL, Gibbins K, Silver RM. Potentially Preventable Stillbirth in a Diverse U.S. Cohort. Obstetrics And Gynecology 2018, 131: 336-343. PMID: 29324601, PMCID: PMC5785410, DOI: 10.1097/aog.0000000000002421.Peer-Reviewed Original ResearchConceptsStillbirth Collaborative Research NetworkPreventable stillbirthsPlacental insufficiencyHypertensive disordersMultiple gestationsMedical complicationsPopulation-based case-control studyDiverse U.S. cohortSpontaneous preterm birthMedical record abstractionWeeks of gestationCases of stillbirthCase-control studyCollaborative research networksResearch NetworkStillbirth reductionPreterm laborPreterm birthPlacental pathologyRecord abstractionNonanomalous fetusesMaternal interviewsPostmortem examinationU.S. cohortStillbirth
2017
Altered fetal growth, placental abnormalities, and stillbirth
Bukowski R, Hansen NI, Pinar H, Willinger M, Reddy UM, Parker CB, Silver RM, Dudley DJ, Stoll BJ, Saade GR, Koch MA, Hogue C, Varner MW, Conway DL, Coustan D, Goldenberg RL, . Altered fetal growth, placental abnormalities, and stillbirth. PLOS ONE 2017, 12: e0182874. PMID: 28820889, PMCID: PMC5562325, DOI: 10.1371/journal.pone.0182874.Peer-Reviewed Original ResearchConceptsFetal growth abnormalitiesAltered fetal growthFetal growthLive birthsPlacental abnormalitiesPlacental findingsGrowth abnormalitiesImpaired placental functionSingleton live birthsCase-control studyCause of deathPatterns of associationSingleton stillbirthsPlacental examinationTerm stillbirthGestational ageRisk factorsPerinatal pathologistsPlacental functionClinical careStillbirthAbnormalitiesStandardized protocolBirthDeathRoute of Delivery in Women With Stillbirth
Boyle A, Preslar JP, Hogue CJ, Silver RM, Reddy UM, Goldenberg RL, Stoll BJ, Varner MW, Conway DL, Saade GR, Bukowski R, Dudley DJ. Route of Delivery in Women With Stillbirth. Obstetrics And Gynecology 2017, 129: 693-698. PMID: 28333794, PMCID: PMC5370197, DOI: 10.1097/aog.0000000000001935.Peer-Reviewed Original ResearchConceptsPrior cesarean deliveryCesarean deliveryObstetric indicationsSingleton stillbirthsUterine ruptureMulticenter case seriesRepeat cesarean deliveryRetrospective chart reviewInduction of laborWeeks of gestationRoute of deliveryMode of deliveryLabor inductionSecondary outcomesChart reviewIntrapartum stillbirthPrimary outcomeSpontaneous laborVaginal deliveryCase seriesMedical recordsTotal casesStillbirthWomenDelivery informationDiagnostic Tests for Evaluation of Stillbirth
Page JM, Christiansen-Lindquist L, Thorsten V, Parker CB, Reddy UM, Dudley DJ, Saade GR, Coustan D, Hogue C, Conway D, Bukowski R, Pinar H, Heuser CC, Gibbins KJ, Goldenberg RL, Silver RM. Diagnostic Tests for Evaluation of Stillbirth. Obstetrics And Gynecology 2017, 129: 699-706. PMID: 28333795, DOI: 10.1097/aog.0000000000001937.Peer-Reviewed Original ResearchConceptsStillbirth Collaborative Research NetworkCause of deathAntiphospholipid antibodiesPlacental pathologyDiagnostic testsEvaluation of stillbirthMedical record abstractionPopulation-based studyCollaborative research networksDeath classification systemResearch NetworkRecord abstractionSyphilis serologyClinical presentationToxicology screenAntibody screenClinical historyMaternal interviewsStillbirthSecondary analysisGenetic testingUseful testBiospecimen collectionStandardized evaluationMost participants
2016
Stillbirth, hypertensive disorders of pregnancy, and placental pathology
Gibbins KJ, Silver RM, Pinar H, Reddy UM, Parker CB, Thorsten V, Willinger M, Dudley DJ, Bukowski R, Saade GR, Koch MA, Conway D, Hogue CJ, Stoll BJ, Goldenberg RL. Stillbirth, hypertensive disorders of pregnancy, and placental pathology. Placenta 2016, 43: 61-68. PMID: 27324101, PMCID: PMC5893308, DOI: 10.1016/j.placenta.2016.04.020.Peer-Reviewed Original ResearchConceptsPlacental pathologyParenchymal infarctionLive birthsPreterm stillbirthSimilar clinical risk factorsStillbirth Collaborative Research NetworkPopulation-based cohort studyFetal vascular lesionsClinical risk factorsFeto-placental ratioGestational hypertensionRetroplacental hematomaHypertensive disordersCohort studyPlacental lesionsVascular lesionsAvascular villiFibrin depositionRisk factorsVascular thrombiStillbirthPregnancySecondary analysisInfarctionGHStillbirths: recall to action in high-income countries
Flenady V, Wojcieszek A, Middleton P, Ellwood D, Erwich J, Coory M, Khong T, Silver R, Smith G, Boyle F, Lawn J, Blencowe H, Leisher S, Gross M, Horey D, Farrales L, Bloomfield F, McCowan L, Brown S, Joseph K, Zeitlin J, Reinebrant H, Cacciatore J, Ravaldi C, Vannacci A, Cassidy J, Cassidy P, Farquhar C, Wallace E, Siassakos D, Heazell A, Storey C, Sadler L, Petersen S, Frøen J, Goldenberg R, Flenady V, Frøen J, Kinney M, de Bernis L, Lawn J, Blencowe H, Heazell A, Leisher S, Ruidiaz J, Carvalho A, Dahlstrom J, East C, Fox J, Gibbons K, Ibiebele I, Kildea S, Gardener G, Lourie R, Wilson P, Gordon A, Jennings B, Kent A, McDonald S, Merchant K, Oats J, Walker S, Raven L, Schirmann A, de Montigny F, Guyon G, Blondel B, de Wall S, Bonham S, Corcoran P, Cregan M, Meany S, Murphy M, Fukui S, Gordijn S, Korteweg F, Cronin R, Mason V, Culling V, Usynina A, Pettersson K, Rådestad I, van Gogh S, Bichara B, Bradley S, Ellis A, Downe S, Draper E, Manktelow B, Scott J, Smith L, Stones W, Lavender T, Duke W, Fretts R, Gold K, McClure E, Reddy U. Stillbirths: recall to action in high-income countries. The Lancet 2016, 387: 691-702. PMID: 26794070, DOI: 10.1016/s0140-6736(15)01020-x.Peer-Reviewed Original ResearchMeSH KeywordsAttitude to HealthData AccuracyDelivery of Health CareDeveloped CountriesFemaleGestational AgeGlobal HealthHealth PolicyHealthcare DisparitiesHospice CareHumansIncomeInternational CooperationPerinatal MortalityPostnatal CarePractice Guidelines as TopicPregnancyPrenatal CareRisk FactorsStereotypingStillbirthConceptsHigh-income countriesStillbirth rateLate gestation stillbirthAdverse socioeconomic circumstancesIntrapartum stillbirthUnexplained stillbirthBereavement careStillbirthCare contributesStillborn childSocioeconomic circumstancesCausal pathwaysAdvantaged counterpartsDisadvantaged familiesEquity gapCareWomen
2014
Association Between Stillbirth and Illicit Drug Use and Smoking During Pregnancy
Varner MW, Silver RM, Hogue C, Willinger M, Parker CB, Thorsten VR, Goldenberg RL, Saade GR, Dudley DJ, Coustan D, Stoll B, Bukowski R, Koch MA, Conway D, Pinar H, Reddy UM. Association Between Stillbirth and Illicit Drug Use and Smoking During Pregnancy. Obstetrics And Gynecology 2014, 123: 113-125. PMID: 24463671, PMCID: PMC3931517, DOI: 10.1097/aog.0000000000000052.Peer-Reviewed Original ResearchConceptsIllicit drug useCotinine assaysDrug useMaternal serum cotinine levelStillbirth Collaborative Research NetworkCannabis useSelf-reported smoking historyRisk of stillbirthLive-birth deliveriesSerum cotinine levelsCase-control studySecond-hand smokeUmbilical cord samplesIllicit drugsDose-response relationshipStillbirth deliverySmoking historyCotinine levelsMaternal serumSerum cotinineBirth deliveryCord homogenateSmoking useCord samplesStillbirth