2024
Optimizing Opioid Prescription Quantity After Cesarean Delivery
Smid M, Clifton R, Rood K, Srinivas S, Simhan H, Casey B, Longo M, Landau R, MacPherson C, Bartholomew A, Sowles A, Reddy U, Rouse D, Bailit J, Thorp J, Chauhan S, Saade G, Grobman W, Macones G. Optimizing Opioid Prescription Quantity After Cesarean Delivery. Obstetrics And Gynecology 2024, 144: 195-205. PMID: 38857509, PMCID: PMC11257794, DOI: 10.1097/aog.0000000000005649.Peer-Reviewed Original ResearchOpioid tabletsCesarean birthOpioid useHuman Development Maternal-Fetal Medicine Units NetworkMaternal-Fetal Medicine Units NetworkPrimary outcomeQuantity of opioid tabletsEunice Kennedy Shriver National Institute of Child HealthOpioid prescription protocolPostcesarean pain managementHistory of opioid useOpioid prescription quantitiesRandomized controlled noninferiority trialNational Institute of Child HealthInstitute of Child HealthPostcesarean analgesiaCesarean deliveryRandomized controlled trialsPain managementPrescription quantitiesFollow-upWeeks postdischargeNoninferiority trialDecision makingChild healthPrediction of metabolic syndrome following a first pregnancy
Kawakita T, Greenland P, Pemberton V, Grobman W, Silver R, Bairey Merz C, McNeil R, Haas D, Reddy U, Simhan H, Saade G. Prediction of metabolic syndrome following a first pregnancy. American Journal Of Obstetrics And Gynecology 2024 PMID: 38527600, DOI: 10.1016/j.ajog.2024.03.031.Peer-Reviewed Original ResearchDevelopment of metabolic syndromeArea under the receiver operating characteristic curveMetabolic syndromeNational Cholesterol Education Program Adult Treatment Panel III criteriaAdult Treatment Panel III criteriaPrevalence of metabolic syndromePrediction of metabolic syndromeProspective cohort studyIn-personSecondary analysisCohort studyIII criteriaInclusion criteriaPregnant individualsPrimary outcomeReceiver operating characteristic curveVisit 2Regression modelsPregnancySyndromeDeliveryUnited StatesCharacteristic curveLASSO regression modelYearsAssociation of Mild Iodine Insufficiency during Pregnancy with Child Neurodevelopment in Patients with Subclinical Hypothyroidism or Hypothyroxinemia
Casey B, Mele L, Peaceman A, Varner M, Reddy U, Wapner R, Thorp J, Saade G, Tita A, Rouse D, Sibai B, Costantine M, Mercer B, Caritis S. Association of Mild Iodine Insufficiency during Pregnancy with Child Neurodevelopment in Patients with Subclinical Hypothyroidism or Hypothyroxinemia. American Journal Of Perinatology 2024, 41: e3326-e3332. PMID: 38228158, PMCID: PMC11153033, DOI: 10.1055/s-0043-1778037.Peer-Reviewed Original ResearchUrinary iodine concentrationSubclinical hypothyroidismSubclinical thyroid diseasePregnant patientsIodine statusIodine insufficiencyThyroid diseaseIodine concentrationMaternal urinary iodine concentrationPrimary outcomePlacebo-controlled treatment trialMaternal iodine statusMild iodine insufficiencyIntelligence quotientFull-scale intelligence quotientYears of ageDifferential Ability Scales-IISingleton gestationsDouble-maskedIdentical placeboLevothyroxine replacementWeeks gestationMaternal urineThyroid screeningSerum thyrotropinBreastfeeding Initiation, Duration, and Associated Factors Among People With Hepatitis C Virus Infection
Grasch J, de Voest J, Saade G, Hughes B, Reddy U, Costantine M, Chien E, Tita A, Thorp J, Metz T, Wapner R, Sabharwal V, Simhan H, Swamy G, Heyborne K, Sibai B, Grobman W, El-Sayed Y, Casey B, Parry S. Breastfeeding Initiation, Duration, and Associated Factors Among People With Hepatitis C Virus Infection. Obstetrics And Gynecology 2024, 143: 449-455. PMID: 38176013, PMCID: PMC10962006, DOI: 10.1097/aog.0000000000005499.Peer-Reviewed Original ResearchHepatitis C virus infectionUndetectable viral loadC virus infectionHuman immunodeficiency virusViral loadHCV seropositivityHCV viremiaBreast milkAssociated FactorsVirus infectionMulticenter observational cohortDetectable viral loadDuration of breastfeedingObstetric characteristicsSingleton gestationsMedian durationObservational cohortSecondary outcomesPrimary outcomeMultivariable analysisSelf-reported initiationImmunodeficiency virusBreastfeeding behaviorBreastfeedingSecondary analysis
2023
Desirability of outcome ranking for obstetrical trials: illustration and application to the ARRIVE trial
SANDOVAL G, GROBMAN W, EVANS S, RICE M, CLIFTON R, CHAUHAN S, COSTANTINE M, GIBSON K, LONGO M, METZ T, MILLER E, PARRY S, REDDY U, ROUSE D, SIMHAN H, THORP J, TITA A, SAADE G, Network E. Desirability of outcome ranking for obstetrical trials: illustration and application to the ARRIVE trial. American Journal Of Obstetrics And Gynecology 2023, 230: 370.e1-370.e12. PMID: 37741532, PMCID: PMC10939984, DOI: 10.1016/j.ajog.2023.09.016.Peer-Reviewed Original ResearchElective inductionARRIVE trialCesarean deliverySecondary outcomesPrimary outcomeVaginal deliveryDesirability of outcomeEunice Kennedy Shriver National InstituteSpontaneous vaginal deliverySevere neonatal complicationsWeeks of gestationOperative vaginal deliveryBetter overall outcomesPerson-centred careNeonatal complicationsObstetric trialsExpectant managementPerinatal deathRandomized trialsDecreased riskPoor outcomeClinical trialsChild healthTreatment scoresOutcome rankingsRisk Factors for Perinatal Transmission of Hepatitis C Virus
Prasad M, Saade G, Clifton R, Sandoval G, Hughes B, Reddy U, Bartholomew A, Salazar A, Chien E, Tita A, Thorp J, Metz T, Wapner R, Sabharwal V, Simhan H, Swamy G, Heyborne K, Sibai B, Grobman W, El-Sayed Y, Casey B, Parry S, Rathore M, Diaz-Velasco R, Puga A, Wiznia A, Kovacs A, Garry D, Macones G. Risk Factors for Perinatal Transmission of Hepatitis C Virus. Obstetrics And Gynecology 2023, 142: 449-456. PMID: 37590978, PMCID: PMC10437102, DOI: 10.1097/aog.0000000000005306.Peer-Reviewed Original ResearchConceptsPerinatal transmissionHCV infectionRisk factorsPrimary outcomeHuman Development Maternal-Fetal Medicine Units NetworkMaternal-Fetal Medicine Units NetworkHepatitis C virus infectionEunice Kennedy Shriver National InstituteC virus infectionPerinatal transmission rateWeeks of gestationHigh viral loadHepatitis C virusMonths of lifePositive test resultsAntepartum bleedingViremic participantsVaginal bleedingHCV RNAViremic individualsViral loadC virusObservational studyVirus infectionDemonstrable viremiaAssociation between Sleep Disordered Breathing and Neonatal Outcomes in Nulliparous Individuals
Delgado A, Kendle A, Randis T, Donda K, Salemi J, Facco F, Parker C, Reddy U, Silver R, Basner R, Chung J, Schubert F, Pien G, Redline S, Parry S, Grobman W, Zee P, Louis J. Association between Sleep Disordered Breathing and Neonatal Outcomes in Nulliparous Individuals. American Journal Of Perinatology 2023, 41: e2418-e2426. PMID: 37380034, DOI: 10.1055/a-2115-0147.Peer-Reviewed Original ResearchSleep-disordered breathingAdverse neonatal outcomesNeonatal outcomesPrimary outcomeRisk ratioApnea-hypopnea indexRespiratory distress syndromeBody mass indexEvents/hConfidence intervalsSleep Disordered BreathingLog-binomial regressionNulliparous individualsHome sleep studiesChronic hypertensionNeonatal morbidityNew onsetPregestational diabetesComposite outcomeRespiratory supportTransient tachypneaDistress syndromeGestational ageMass indexMaternal riskCervical Pessary for Prevention of Preterm Birth in Individuals With a Short Cervix
Hoffman M, Clifton R, Biggio J, Saade G, Ugwu L, Longo M, Bousleiman S, Clark K, Grobman W, Frey H, Chauhan S, Dugoff L, Manuck T, Chien E, Rouse D, Simhan H, Esplin M, Macones G, Bickus M, Facco F, Tita A, Grant J, Casey B, Harris S, Harper L, Dunn D, Longo S, Hendricks M, Lata-Arias K, Costantine M, Bartholomew A, Cline D, Harper S, Ward C, Gardner N, Brindle S, Weigand S, McKenna D, Snow E, Fennig K, Habli M, Lambers D, McClellan M, Metz T, Sowles A, Varner M, Hill K, Morby V, Meadows C, Allard D, Werner E, Rousseau J, Milano J, Pettker C, Leventhal J, Gyamfi-Bannerman C, Wapner R, Carmona V, Firman B, Vanneman A, Palomares K, Beche I, Skupski D, Chan-Akeley R, Salazar A, Pacheco L, McCoy L, Saad A, Jain S, Omere C, Clifford C, McDonnold M, Chien E, Dalton W, Polito L, Milluzi C, Kushner K, Maile A, Bell J, Hackney D, Ortiz F, Timlin S, Goodnight W, Manuck T, Beamon C, Nun H, Eichelberger K, Moore A, Hughes B, Ferrara J, Grobman W, Mallett G, Stein L, Miller E, Plunkett B, Kearns K, Palatnik A, Malone T, Parry S, Pizzi C, Craig J, Filipczak A, Thom E, Doherty L, Hubbard A, Erikson P, Pinto T, Marcharchand P, Reddy U, Miodovnik M, Archer S. Cervical Pessary for Prevention of Preterm Birth in Individuals With a Short Cervix. JAMA 2023, 330: 340-348. PMID: 37490086, PMCID: PMC10369212, DOI: 10.1001/jama.2023.10812.Peer-Reviewed Original ResearchConceptsCervical pessaryUsual carePreterm birthShort cervixVaginal progesteroneCervical lengthSingleton pregnanciesFetal deathPrimary outcomeInfant deathPrior spontaneous preterm birthTransvaginal ultrasound cervical lengthCervical pessary placementWeeks 0 daysSpontaneous preterm birthUltrasound cervical lengthWeeks 6 daysThird interim analysisNeonatal/infant mortalityPreterm deliverySingleton gestationsBaseline characteristicsUltrasound evidencePessary placementTransvaginal ultrasoundPROMPT: Prospective Meta-analysis for Pessary Trials Study Protocol
Thom E, Saade G, Askie L, Ugwu L, Mol B, Vayssiere C, Norman J, Pajkrt E, Clifton R, Biggio J, Arnaud C, Berghella V, Canino M, Carreras E, Dugoff L, Hoffman M, Pacagnella R, Reddy U, Saccone G, van 't Hooft J, Dang V, Collaboration F. PROMPT: Prospective Meta-analysis for Pessary Trials Study Protocol. American Journal Of Perinatology 2023, 41: e2230-e2237. PMID: 37429323, PMCID: PMC10776795, DOI: 10.1055/s-0043-1771018.Peer-Reviewed Original ResearchShort cervical lengthPreterm birthIndividual patient dataShort cervixRandomized trialsPessary trialCervical lengthTwin gestationsSubsequent spontaneous preterm birthLong-term neurological disabilityOngoing randomized trialsSpontaneous preterm birthTrial study protocolWeeks of gestationProspective Meta-AnalysisSignificant health issueCervical supportNeonatal morbidityPreterm deliverySingleton gestationsSecondary outcomesFetal deathNeurological disabilityPrimary outcomeWeeks' gestationAssociation of maternal body mass index with success and outcomes of attempted operative vaginal delivery
Grasch J, Venkatesh K, Grobman W, Silver R, Saade G, Mercer B, Yee L, Scifres C, Parry S, Simhan H, Reddy U, Frey H. Association of maternal body mass index with success and outcomes of attempted operative vaginal delivery. American Journal Of Obstetrics & Gynecology MFM 2023, 5: 101081. PMID: 37422004, DOI: 10.1016/j.ajogmf.2023.101081.Peer-Reviewed Original ResearchConceptsMaternal body mass indexBody mass indexOperative vaginal deliveryVaginal delivery attemptComposite maternal morbidityComposite neonatal morbidityVaginal deliveryMass indexNeonatal morbidityCesarean deliveryMaternal morbidityAdverse outcomesSecond-stage cesarean deliveryBody mass index groupsBody mass index categoriesNulliparous Pregnancy Outcomes StudyNonanomalous singleton pregnanciesNeonatal adverse outcomesMultivariable logistic regressionPregnancy Outcomes StudyNulliparous individualsDose-dependent mannerSecondary outcomesSingleton pregnanciesPrimary outcomeLow-Dose Aspirin during Pregnancy and Postpartum Bleeding
White K, Son M, Lundsberg L, Culhane J, Partridge C, Reddy U, Merriam A. Low-Dose Aspirin during Pregnancy and Postpartum Bleeding. American Journal Of Perinatology 2023, 40: 1390-1397. PMID: 37211010, DOI: 10.1055/a-2096-5199.Peer-Reviewed Original ResearchConceptsLow-dose aspirinPostpartum blood lossTiming of discontinuationBlood lossPostpartum bleedingPostpartum hemorrhageLDA useUse of LDARed blood cell transfusionBlood cell transfusionRetrospective cohort studySystemic lupus erythematosusTime of deliveryDiagnosis of diabetesLogistic regression modelingElectronic medical recordsAspirin 81Ideal dosingPreeclampsia preventionCell transfusionDose aspirinCohort studyHypertensive diseaseLupus erythematosusPrimary outcomeThe Association between Infant Birth Weight, Head Circumference, and Neurodevelopmental Outcomes
Costantine M, Tita A, Mele L, Casey B, Peaceman A, Varner M, Reddy U, Wapner R, Thorp J, Saade G, Rouse D, Sibai B, Mercer B, Caritis S, Bethesda F. The Association between Infant Birth Weight, Head Circumference, and Neurodevelopmental Outcomes. American Journal Of Perinatology 2023, 41: e1313-e1323. PMID: 36791785, PMCID: PMC10425571, DOI: 10.1055/s-0043-1761920.Peer-Reviewed Original ResearchYears of ageChild intelligence quotientSecondary outcomesBirth weightHead circumferenceNeurodevelopmental outcomesPrimary outcomeGestational ageHypothyroid disordersPopulation nomogramsGestational age birth weightIntelligence quotientHigher body mass indexLGA birth weightSGA birth weightInfant birth weightAdverse neurodevelopmental outcomesBody mass indexLarger head circumferenceFetal growth standardsOdds of childrenDetection of newbornsFetal Growth StudiesAGA neonatesSGA neonates
2022
Association of Social Determinants of Health and Clinical Factors with Postpartum Hospital Readmissions among Nulliparous Individuals
Kumar N, Grobman W, Haas D, Silver R, Reddy U, Simhan H, Wing D, Mercer B, Yee L. Association of Social Determinants of Health and Clinical Factors with Postpartum Hospital Readmissions among Nulliparous Individuals. American Journal Of Perinatology 2022, 40: 348-355. PMID: 36427510, DOI: 10.1055/s-0042-1758485.Peer-Reviewed Original ResearchConceptsPostpartum readmissionSocial determinantsHypertensive disordersHigher oddsMulticenter prospective cohort studyPostpartum hospital readmissionProspective cohort studyInitial hospital dischargeHemorrhage requiring transfusionSuch risk factorsAntecedent diagnosisHDP patientsNulliparous participantsGestational diabetesIntrapartum complicationsPerinatal morbidityCesarean deliveryCohort studyHospital dischargeClinical factorsHospital readmissionPrimary outcomeBivariable analysisModifiable factorsInsurance statusNeonatal outcomes by delivery indication after administration of antenatal late preterm corticosteroids
Deshmukh U, Lundsberg L, Pettker C, Rouse D, Reddy U. Neonatal outcomes by delivery indication after administration of antenatal late preterm corticosteroids. AJOG Global Reports 2022, 2: 100097. PMID: 36536839, PMCID: PMC9758401, DOI: 10.1016/j.xagr.2022.100097.Peer-Reviewed Original ResearchPreterm prelabor ruptureLate preterm deliveryPreterm delivery groupLate preterm periodNeonatal respiratory complicationsPreterm labor groupPreterm deliverySpontaneous preterm laborPreterm laborPrelabor rupturePrimary outcomeDelivery indicationsDelivery groupAntenatal corticosteroidsNeonatal complicationsPlacebo groupRespiratory complicationsPreterm periodLower oddsAntenatal Late Preterm Steroids trialNewborn intensive care unit admissionIntensive care unit admissionMultivariable logistic regression modelLate preterm infantsNeonatal respiratory outcomes
2017
Route of Delivery in Women With Stillbirth
Boyle A, Preslar JP, Hogue CJ, Silver RM, Reddy UM, Goldenberg RL, Stoll BJ, Varner MW, Conway DL, Saade GR, Bukowski R, Dudley DJ. Route of Delivery in Women With Stillbirth. Obstetrics And Gynecology 2017, 129: 693-698. PMID: 28333794, PMCID: PMC5370197, DOI: 10.1097/aog.0000000000001935.Peer-Reviewed Original ResearchConceptsPrior cesarean deliveryCesarean deliveryObstetric indicationsSingleton stillbirthsUterine ruptureMulticenter case seriesRepeat cesarean deliveryRetrospective chart reviewInduction of laborWeeks of gestationRoute of deliveryMode of deliveryLabor inductionSecondary outcomesChart reviewIntrapartum stillbirthPrimary outcomeSpontaneous laborVaginal deliveryCase seriesMedical recordsTotal casesStillbirthWomenDelivery information
2015
A Randomized Trial of Intrapartum Fetal ECG ST-Segment Analysis
Belfort M, Saade G, Thom E, Blackwell S, Reddy U, Thorp J, Tita A, Miller R, Peaceman A, McKenna D, Chien E, Rouse D, Gibbs R, El-Sayed Y, Sorokin Y, Caritis S, VanDorsten J. A Randomized Trial of Intrapartum Fetal ECG ST-Segment Analysis. Obstetrical & Gynecological Survey 2015, 70: 735-737. DOI: 10.1097/ogx.0000000000000276.Peer-Reviewed Original ResearchST-segment analysisFetal ECG ST segment analysisElectronic fetal monitoringApgar scoreCesarean deliveryNeonatal encephalopathyOperative deliveryPrimary outcomeVaginal deliveryRandomized trialsOpen groupElectronic fetal heart rate monitorMasked groupElectronic fetal heart rate monitoringFetal heart rate patternsUmbilical artery blood pHContinuous electronic fetal monitoringIntrapartum fetal deathFetal heart rate monitoringPrimary study outcomeOperative vaginal deliveryWeeks of gestationHeart rate patternsSignificant differencesFetal heart rate monitorThe association of beta‐2 adrenoceptor genotype with short‐cervix mediated preterm birth: a case–control study
Miller R, Smiley R, Thom E, Grobman W, Iams J, Mercer B, Saade G, Tita A, Reddy U, Rouse D, Sorokin Y, Blackwell S, Esplin, Tolosa J, Caritis, Network E. The association of beta‐2 adrenoceptor genotype with short‐cervix mediated preterm birth: a case–control study. BJOG An International Journal Of Obstetrics & Gynaecology 2015, 122: 1387-1394. PMID: 25600430, PMCID: PMC4508241, DOI: 10.1111/1471-0528.13243.Peer-Reviewed Original ResearchConceptsShort cervixCervical lengthAR genotypeMaternal-Fetal Medicine Units NetworkEunice Kennedy Shriver National InstituteNormal cervical lengthShort cervical lengthShort cervix groupPreterm birth riskCase-control studyRace/ethnicitySpontaneous PTBNulliparous womenPregnancy outcomesPreterm birthTransvaginal sonogramsPrimary outcomePTB riskSecond trimesterAncillary studiesChild healthBirth riskCervixAdrenoceptor genotypeControl group