2024
Cannabis Exposure and Adverse Pregnancy Outcomes Related to Placental Function
Metz T, Allshouse A, McMillin G, Greene T, Chung J, Grobman W, Haas D, Mercer B, Parry S, Reddy U, Saade G, Simhan H, Silver R. Cannabis Exposure and Adverse Pregnancy Outcomes Related to Placental Function. Obstetric Anesthesia Digest 2024, 44: 139-140. DOI: 10.1097/01.aoa.0001026572.72882.bd.Peer-Reviewed Original ResearchExposure to cannabisCannabis usePlacental functionPregnancy outcomesPrevalence of cannabis usePoor fetal growthAdverse pregnancy outcomesInfluence pregnancy outcomePlacental dysfunctionCannabis exposureFetal growthPregnant individualsSelf-reported useTobacco useCannabisDrug usePregnancyOutcome relationsPotential legal consequencesOutcomesAssociationExposureUseDysfunctionPublished researchPregnancy Outcomes in Patients With Hepatitis C Virus Infection.
Hughes B, Sandoval G, Saade G, Clifton R, Reddy U, Bartholomew A, Salazar A, Chien E, Tita A, Thorp J, Metz T, Wapner R, Sabharwal V, Simhan H, Swamy G, Heyborne K, Sibai B, Grobman W, El-Sayed Y, Casey B, Parry S, Macones G, Prasad M. Pregnancy Outcomes in Patients With Hepatitis C Virus Infection. Obstetrics And Gynecology 2024 PMID: 39173174, DOI: 10.1097/aog.0000000000005703.Peer-Reviewed Original ResearchSmall-for-gestational-ageHepatitis C virusHepatitis C virus infectionCase groupIncreased oddsPreterm birthNeonatal infectionGestational diabetesMaternal outcomesHCV infectionBirth weightSmall-for-gestational-age birth weightAdmission to neonatal intensive careControl groupIncreased odds of preterm birthPositive hepatitis C virusOdds of NICU admissionOutcomes associated with pregnancyMulticenter prospective cohort studyOdds of preterm birthMaternal HCV infectionMaternal medical comorbiditiesSGA birth weightAdverse maternal outcomesC virus infectionRadon exposure and gestational diabetes mellitus: the nuMoM2b study
Zhang Y, Angley M, Lu L, Smith B, Grobman W, Wylie B, Reddy U, Kahe K. Radon exposure and gestational diabetes mellitus: the nuMoM2b study. ISEE Conference Abstracts 2024, 2024 DOI: 10.1289/isee.2024.0948.Peer-Reviewed Original ResearchAntepartum Yoga and Pregnancy Outcomes in Nulliparous Individuals: A Retrospective Cohort Study
Kawakita T, Atwani R, Huang J, Greenland P, Merz C, Grobman W, Christman M, Silver R, Mcneil R, Reddy U, Chung J, Parry S, Saade G. Antepartum Yoga and Pregnancy Outcomes in Nulliparous Individuals: A Retrospective Cohort Study. American Journal Of Obstetrics & Gynecology MFM 2024, 101465. PMID: 39142536, DOI: 10.1016/j.ajogmf.2024.101465.Peer-Reviewed Original ResearchProgression of Gestational Subclinical Hypothyroidism and Hypothyroxinemia to Overt Hypothyroidism After Pregnancy: Pooled Analysis of Data from Two Randomized Controlled Trials
Varner M, Mele L, Casey B, Peaceman A, Reddy U, Wapner R, Thorp J, Saade G, Tita A, Rouse D, Sibai B, Costantine M, Mercer B, Caritis S, Bethesda. Progression of Gestational Subclinical Hypothyroidism and Hypothyroxinemia to Overt Hypothyroidism After Pregnancy: Pooled Analysis of Data from Two Randomized Controlled Trials. Thyroid 2024 PMID: 39028022, DOI: 10.1089/thy.2023.0616.Peer-Reviewed Original ResearchSubclinical hypothyroidismOvert hypothyroidismAssociated with higher ratesTPO levelsThyroid peroxidaseYear 5Gestational subclinical hypothyroidismNormal free T4Multicenter treatment trialThyroid replacement therapyYear of deliveryThyrotropin (TSHThyroid peroxidase levelsYear 1Randomized controlled trialsWeeks gestationPlacebo groupTSH valuesMaternal serumReplacement therapyFree T4Higher ratesHypothyroxinemiaThyroid functionHypothyroidismMaternal Implications of Fetal Anomalies: A Population-Based Cross-Sectional Study
Atwani R, Aziz M, Saade G, Reddy U, Kawakita T. Maternal Implications of Fetal Anomalies: A Population-Based Cross-Sectional Study. American Journal Of Obstetrics & Gynecology MFM 2024, 101440. PMID: 39089580, DOI: 10.1016/j.ajogmf.2024.101440.Peer-Reviewed Original ResearchCongenital diaphragmatic herniaCongenital heart diseasePresence of fetal anomaliesAdjusted relative risksFetal anomaliesCleft lipMaternal morbidityDiaphragmatic herniaAdjusted risk differencesChromosomal disordersMultiple anomaliesLimb anomaliesHeart diseaseMaternal intensive care unit admissionRisk of severe maternal morbidityAssociated with maternal morbidityCyanotic congenital heart diseaseMultiple fetal anomaliesRisk of SMMAdverse maternal health outcomesIntensive care unit admissionAdverse maternal outcomesPopulation-based cross-sectional studySevere maternal morbidityIncreased absolute riskDiet quality, community food access, and glycemic control among nulliparous individuals with diabetes
Venkatesh K, Yee L, Wu J, Joseph J, Garner J, McNeil R, Scifres C, Mercer B, Reddy U, Silver R, Saade G, Parry S, Simhan H, Post R, Walker D, Grobman W. Diet quality, community food access, and glycemic control among nulliparous individuals with diabetes. Primary Care Diabetes 2024 PMID: 38972826, DOI: 10.1016/j.pcd.2024.06.011.Peer-Reviewed Original ResearchLarge-Scale Proteomics in Early Pregnancy and Hypertensive Disorders of Pregnancy
Greenland P, Segal M, McNeil R, Parker C, Pemberton V, Grobman W, Silver R, Simhan H, Saade G, Ganz P, Mehta P, Catov J, Merz C, Varagic J, Khan S, Parry S, Reddy U, Mercer B, Wapner R, Haas D. Large-Scale Proteomics in Early Pregnancy and Hypertensive Disorders of Pregnancy. JAMA Cardiology 2024, 9 PMID: 38958943, PMCID: PMC11223045, DOI: 10.1001/jamacardio.2024.1621.Peer-Reviewed Original ResearchArea under the receiver operating characteristic curveCase-control studyHypertensive disordersEarly pregnancyClinical dataSmall-for-gestational-age infantsPrediction of hypertensive disordersSmall-for-gestational-ageHypertensive disorders of pregnancyPrediction of HDPDisorders of pregnancyNested case-control studyPlasma samplesMulticenter observational studyStored plasma samplesReceiver operating characteristic curveBody mass indexGestational hypertensionNon-Hispanic blacksPreterm birthFetal sexFirst-trimesterNon-Hispanic whitesPregnancy outcomesMaternal racePre-conceptional Magnesium Intake and Low Birth Weight: Findings From the nuMoM2b Study
Kahe K, Zhang Y, Angley M, Reddy U. Pre-conceptional Magnesium Intake and Low Birth Weight: Findings From the nuMoM2b Study. Current Developments In Nutrition 2024, 8: 103076. DOI: 10.1016/j.cdnut.2024.103076.Peer-Reviewed Original ResearchPreconceptional Calcium Intake and Hypertensive Disorders of Pregnancy
Lu L, Zhang Y, Angley M, Reddy U, Fly A, Kahe K. Preconceptional Calcium Intake and Hypertensive Disorders of Pregnancy. Current Developments In Nutrition 2024, 8: 103292. DOI: 10.1016/j.cdnut.2024.103292.Peer-Reviewed Original ResearchAssociation of Maternal Zinc Intake With Hypertensive Disorders of Pregnancy: The nuMoM2b Study
Lu L, Zhang Y, Angley M, Reddy U, Fly A, Kahe K. Association of Maternal Zinc Intake With Hypertensive Disorders of Pregnancy: The nuMoM2b Study. Current Developments In Nutrition 2024, 8: 103018. DOI: 10.1016/j.cdnut.2024.103018.Peer-Reviewed Original ResearchAssociation of neighborhood social determinants of health and hypertensive disorders of pregnancy
Bank T, Lynch C, Yee L, Johnson J, Wu J, McNeil R, Mercer B, Simhan H, Reddy U, Silver R, Parry S, Saade G, Chung J, Wapner R, Grobman W, Venkatesh K. Association of neighborhood social determinants of health and hypertensive disorders of pregnancy. AJOG Global Reports 2024, 4: 100372. PMID: 39114583, PMCID: PMC11304865, DOI: 10.1016/j.xagr.2024.100372.Peer-Reviewed Original ResearchRestless Legs Syndrome and Adverse Perinatal Outcomes
Friedlander R, Huang X, Kim M, Zee P, Khan S, Greenland P, Facco F, Chung J, Grobman W, Haas D, McNeil R, Mercer B, Reddy U, Saade G, Silver R, Wiener L, Yee L. Restless Legs Syndrome and Adverse Perinatal Outcomes. American Journal Of Obstetrics & Gynecology MFM 2024, 6: 101401. PMID: 38871296, DOI: 10.1016/j.ajogmf.2024.101401.Peer-Reviewed Original ResearchOptimizing Opioid Prescription Quantity After Cesarean Delivery
Smid M, Clifton R, Rood K, Srinivas S, Simhan H, Casey B, Longo M, Landau R, MacPherson C, Bartholomew A, Sowles A, Reddy U, Rouse D, Bailit J, Thorp J, Chauhan S, Saade G, Grobman W, Macones G. Optimizing Opioid Prescription Quantity After Cesarean Delivery. Obstetrics And Gynecology 2024, 144: 195-205. PMID: 38857509, PMCID: PMC11257794, DOI: 10.1097/aog.0000000000005649.Peer-Reviewed Original ResearchOpioid tabletsCesarean birthOpioid useHuman Development Maternal-Fetal Medicine Units NetworkMaternal-Fetal Medicine Units NetworkPrimary outcomeQuantity of opioid tabletsEunice Kennedy Shriver National Institute of Child HealthOpioid prescription protocolPostcesarean pain managementHistory of opioid useOpioid prescription quantitiesRandomized controlled noninferiority trialNational Institute of Child HealthInstitute of Child HealthPostcesarean analgesiaCesarean deliveryRandomized controlled trialsPain managementPrescription quantitiesFollow-upWeeks postdischargeNoninferiority trialDecision makingChild healthDesign, rationale and protocol for Glycemic Observation and Metabolic Outcomes in Mothers and Offspring (GO MOMs): an observational cohort study
Group T, Scholtens D, LeBlanc E, Vesco K, Amy D, Bays K, Massimino S, Robinson S, Schell K, Walters G, Hillier T, Oshiro C, Cordero S, Howick C, Kim L, Martinez Y, Pishchalenko O, Wastlova V, Zork N, Mourad M, Lonier J, Reddy U, Acevedo J, Castillo J, Gomez M, Peguero B, Facco F, Feghali M, Bocan H, Stramowski S, Powe C, Edlow A, Barth W, Nathan D, Azevedo R, Baez A, Iroajanma C, Larkin M, Maya J, Michalopolous C, Neamonitaki N, Thangthaeng N, Yee L, Lowe W, Grobman W, Szmuilowicz E, Aguirre A, Guevara E, Mallett G, Matos S, Tyagi S, Spadola A, Catalano P, Azimirad A, Werner E, Rouse D, Malloy M, Parra F, Sherr J, Merriam A, Bitterman S, Considine E, Leventhal J, Perley L, Rink L, Steffen A, Thompson B, Zgorski M, Steffes M, Arends V, Killeen A, Siddique J, Bustamante P, Cheung Y, Freeze C, Grott T, Kuang A, Tull M, Linder B. Design, rationale and protocol for Glycemic Observation and Metabolic Outcomes in Mothers and Offspring (GO MOMs): an observational cohort study. BMJ Open 2024, 14: e084216. PMID: 38851233, PMCID: PMC11163666, DOI: 10.1136/bmjopen-2024-084216.Peer-Reviewed Original ResearchConceptsLarge-for-gestational-age birth weightMetabolic outcomesLarge-for-gestational-ageDiagnosis of gestational diabetesOral glucose tolerance testAdverse pregnancy outcomesVanderbilt University Institutional Review BoardCourse of pregnancyObservational cohort studyGlucose tolerance testNational Institute of DiabetesDigestive and Kidney DiseasesGDM treatmentWeeks gestationDetect such abnormalitiesPerinatal outcomesGDM screeningInstitutional review boardGestational diabetesFirst-trimesterPregnancy outcomesEarly pregnancyGlucose abnormalitiesBirth weightPregnant adultsInduction of labor versus expectant management among low-risk patients with one prior cesarean delivery
Ukoha E, Wen T, Reddy U. Induction of labor versus expectant management among low-risk patients with one prior cesarean delivery. American Journal Of Obstetrics And Gynecology 2024 PMID: 38852849, DOI: 10.1016/j.ajog.2024.06.001.Peer-Reviewed Original ResearchInduction of laborNeonatal morbidity compositeOperative vaginal deliveryMaternal morbidity compositeVaginal deliveryExposure of interestCesarean deliveryIntensive care unit admissionMorbidity compositeWeeks 6 daysWeeks 0 daysExpectant management groupLow-risk patientsPeripartum hysterectomyUterine ruptureLikelihood of vaginal deliveryRate of uterine ruptureUnit admissionElective induction of laborLog-binomial regression modelsBirth certificate dataConfidence intervalsExpectant managementAssociated with increased likelihoodNeonatal morbidity outcomesCannabis Exposure and Adverse Pregnancy Outcomes Related to Placental Function
Metz T, Allshouse A, McMillin G, Greene T, Chung J, Grobman W, Haas D, Mercer B, Parry S, Reddy U, Saade G, Simhan H, Silver R. Cannabis Exposure and Adverse Pregnancy Outcomes Related to Placental Function. Obstetrical & Gynecological Survey 2024, 79: 307-309. DOI: 10.1097/ogx.0000000000001289.Peer-Reviewed Original ResearchA Multi-Site Study to Develop and Validate First Trimester, Circulating Microparticle Biomarkers for Tiered Risk Stratification of Spontaneous Preterm Birth in Nulliparas
Rosenblatt K, Zhang Z, Doss R, Gurnani P, Grobman W, Silver R, Parry S, Reddy U, Cao S, Haas D. A Multi-Site Study to Develop and Validate First Trimester, Circulating Microparticle Biomarkers for Tiered Risk Stratification of Spontaneous Preterm Birth in Nulliparas. American Journal Of Obstetrics And Gynecology 2024 PMID: 38789072, DOI: 10.1016/j.ajog.2024.05.032.Peer-Reviewed Original ResearchIn vitro diagnostic multivariate index assaySpontaneous preterm birthGestational agePreterm birthLow riskModerate riskPrediction of spontaneous preterm birthHR groupRisk ratioHigh riskMonitoring Mothers-to-BeNulliparous Pregnancy Outcomes StudyTrimester of pregnancyMultivariate index assayPregnancy Outcomes StudyNested case-control designStatistically significant differencePregnant patientsWeeks gestationMass spectrometry assayCase-control designRisk stratificationStratify riskMothers-to-beStratification toolStillbirth: we can do better
Silver R, Reddy U. Stillbirth: we can do better. American Journal Of Obstetrics And Gynecology 2024, 231: 152-165. PMID: 38789073, DOI: 10.1016/j.ajog.2024.05.042.Peer-Reviewed Original ResearchResource countriesNon-Hispanic blacksPrevention of stillbirthNon-Hispanic whitesOther Pacific IslanderRate of stillbirthLow-income countriesStillbirth rateStillbirthRisk factorsPacific IslandersGenetic etiologyPlacental assessmentEmotion managementRisk stratificationPreventionUnited StatesPregnancyRiskDisparitiesEpidemiologyCountriesU.S.WhiteSocioeconomic Disadvantage in Pregnancy and Postpartum Risk of Cardiovascular Disease
Venkatesh K, Khan S, Catov J, Wu J, McNeil R, Greenland P, Wu J, Levine L, Yee L, Simhan H, Haas D, Reddy U, Saade G, Silver R, Merz C, Grobman W. Socioeconomic Disadvantage in Pregnancy and Postpartum Risk of Cardiovascular Disease. American Journal Of Obstetrics And Gynecology 2024 PMID: 38759711, DOI: 10.1016/j.ajog.2024.05.007.Peer-Reviewed Original ResearchSocial determinants of healthArea Deprivation IndexNeighborhood-level socioeconomic disadvantageSocioeconomic disadvantageSocial determinantsFramingham risk scoreRisk scoreCardiovascular diseaseNeighborhood-level social determinantsModified Poisson regression modelsDeterminants of healthParticipant's home addressMedian area deprivation indexMaternal cardiovascular healthPoisson regression modelsLong-term cardiovascular diseaseRisk of cardiovascular diseaseMothers-to-bePredicted riskRisk of ASCVDCensus block levelRisk of long-term cardiovascular diseaseMultivariate linear regressionDeprivation indexNulliparous individuals