Featured Publications
Comparison of Female Ovarian Reserve Before vs After COVID-19 Vaccination
Yang L, Neal S, Lee T, Chou A, Schutt A, Gibbons W. Comparison of Female Ovarian Reserve Before vs After COVID-19 Vaccination. JAMA Network Open 2023, 6: e2318804. PMID: 37326996, PMCID: PMC10276301, DOI: 10.1001/jamanetworkopen.2023.18804.Peer-Reviewed Original Research
2021
Fetal programming of polycystic ovary syndrome: Effects of androgen exposure on prenatal ovarian development
Barsky M, Merkison J, Hosseinzadeh P, Yang L, Bruno-Gaston J, Dunn J, Gibbons W, Blesson C. Fetal programming of polycystic ovary syndrome: Effects of androgen exposure on prenatal ovarian development. The Journal Of Steroid Biochemistry And Molecular Biology 2021, 207: 105830. PMID: 33515680, PMCID: PMC8056856, DOI: 10.1016/j.jsbmb.2021.105830.Peer-Reviewed Original ResearchConceptsGene expressionPolycystic ovary syndromeOvarian developmentDifferential gene expressionFetal gonadal developmentDownregulated genesTranscriptional pathwaysCandidate genesMitochondrial studiesMitochondrial oxygen consumptionProton leakOvary syndromeGonadal developmentMitochondrial functionFetal programmingMitochondrial ultrastructureStrong hereditary componentMitochondrial dysfunctionMitochondrial efficiencyMitochondriaAndrogen exposureGenesInheritance patternOocyte maturationAndrogen programming
2015
DNMT3A in haematological malignancies
Yang L, Rau R, Goodell M. DNMT3A in haematological malignancies. Nature Reviews Cancer 2015, 15: 152-165. PMID: 25693834, PMCID: PMC5814392, DOI: 10.1038/nrc3895.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsHaematopoietic stem cell differentiationStem cell differentiationStem cell programAberrant DNA methylationDominant negative inhibitorImportant biological relationshipsDifferentiated lineagesHistone methyltransferasesDNA methyltransferasesRegulatory domainDNA methylationMechanistic functionGene expressionHSC progenyMethyltransferase 3AImportant new targetHSC expansionCell differentiationUnique mutational profileDNMT3ACell programHuman HSCsStem cellsEnzymatic activityMutations
2013
Large conserved domains of low DNA methylation maintained by Dnmt3a
Jeong M, Sun D, Luo M, Huang Y, Challen G, Rodriguez B, Zhang X, Chavez L, Wang H, Hannah R, Kim S, Yang L, Ko M, Chen R, Göttgens B, Lee J, Gunaratne P, Godley L, Darlington G, Rao A, Li W, Goodell M. Large conserved domains of low DNA methylation maintained by Dnmt3a. Nature Genetics 2013, 46: 17-23. PMID: 24270360, PMCID: PMC3920905, DOI: 10.1038/ng.2836.Peer-Reviewed Original ResearchMeSH Keywords5-MethylcytosineAnimalsBase SequenceConserved SequenceCpG IslandsCytosineDatabases, GeneticDNA (Cytosine-5-)-MethyltransferasesDNA MethylationDNA Methyltransferase 3AEpigenesis, GeneticGene Expression RegulationHematopoietic Stem CellsHistonesHumansLeukemiaMaleMiceMice, Inbred C57BLMice, Mutant Strains
2008
Placental expression of ceruloplasmin in pregnancies complicated by severe preeclampsia
Guller S, Buhimschi CS, Y Y, Huang T, Yang L, Kuczynski E, Zambrano E, Lockwood CJ, Buhimschi IA. Placental expression of ceruloplasmin in pregnancies complicated by severe preeclampsia. Laboratory Investigation 2008, 88: 1057-1067. PMID: 18679377, PMCID: PMC2682720, DOI: 10.1038/labinvest.2008.74.Peer-Reviewed Original ResearchConceptsPlasminogen activator inhibitor-1Severe preeclampsiaReperfusion injurySFlt-1Soluble fms-like tyrosine kinase-1Fms-like tyrosine kinase-1Ischemia/reperfusion injuryLife-threatening syndromeSubsequent reperfusion injuryTerm control groupPathophysiology of preeclampsiaTyrosine kinase-1Activator inhibitor-1Release of factorsSignificant increasePresence of mRNAUpregulation of mRNACeruloplasmin mRNAPlacental damagePlacental factorsMicroarray gene profilingEndothelium dysfunctionPE placentasQuantitative real-time PCRIntervillous space
2005
Expression and Regulation of Glucocorticoid Receptor in Human Placental Villous Fibroblasts
Lee MJ, Wang Z, Yee H, Ma Y, Swenson N, Yang L, Kadner SS, Baergen RN, Logan SK, Garabedian MJ, Guller S. Expression and Regulation of Glucocorticoid Receptor in Human Placental Villous Fibroblasts. Endocrinology 2005, 146: 4619-4626. PMID: 16055431, DOI: 10.1210/en.2005-0235.Peer-Reviewed Original ResearchConceptsGC receptorSmooth muscle cellsHuman placentaGR levelsHormone treatmentShort-term GC treatmentMuscle cellsLong-term hormone treatmentVascular smooth muscle cellsGR protein expressionGR mRNA levelsPlacental cell typesNormal term human placentasTotal GR levelsTerm human placentaCell typesGR antibodyGC treatmentHormone exposureStem villiCytotrophoblast cellsGlucocorticoid receptorPlacental fibroblastsTerminal villiVillous fibroblasts