2021
Comparison of open and a novel closed vitrification system with slow freezing for human ovarian tissue cryopreservation
Sugishita Y, Taylan E, Kawahara T, Shahmurzada B, Suzuki N, Oktay K. Comparison of open and a novel closed vitrification system with slow freezing for human ovarian tissue cryopreservation. Journal Of Assisted Reproduction And Genetics 2021, 38: 2723-2733. PMID: 34398400, PMCID: PMC8581089, DOI: 10.1007/s10815-021-02297-9.Peer-Reviewed Original ResearchConceptsFollicle survivalCortical piecesPrimary folliclesHuman ovarian tissue cryopreservationOvarian tissue cryopreservationCell death pathway activationOvarian cortical piecesPrimordial follicle survivalPrimordial follicle densityHuman ovarian tissueClosed vitrification systemTissue cryopreservationDNA damageOvarian tissueHistological analysisPathway activationApoptosis rateDevice groupSlow freezing
2019
Chapter 30 Autologous Transplantation of Human Ovarian Tissue
Taylan E, Oktay K. Chapter 30 Autologous Transplantation of Human Ovarian Tissue. 2019, 493-500. DOI: 10.1016/b978-0-12-813209-8.00030-3.Peer-Reviewed Original ResearchHuman ovarian tissueOvarian tissueAutologous transplantationFrozen-thawed human ovarian tissueOvarian tissue cryopreservationReproductive-age womenPremature ovarian failureOvarian reserveGonadotoxic therapyAntineoplastic treatmentGonadotoxic treatmentFertility preservationOvarian cortexOvarian failureAge womenReproductive surgeryTissue cryopreservationEndocrine functionPrimordial folliclesPrepubertal ageNononcological diseasesTransplantationTreatmentDiseaseTissue
2017
Vitrification versus slow freezing of human ovarian tissue: a comparison of follicle survival and DNA damage
Kawahara T, Sugishita Y, Taylan E, Suzuki N, Moy F, Oktay K. Vitrification versus slow freezing of human ovarian tissue: a comparison of follicle survival and DNA damage. Fertility And Sterility 2017, 108: e56-e57. DOI: 10.1016/j.fertnstert.2017.07.179.Peer-Reviewed Original Research
2000
Restoration of Ovarian Function After Autologous Transplantation of Human Ovarian Tissue in the Forearm
Oktay K, Aydin B, Economos K, Rucinski J. Restoration of Ovarian Function After Autologous Transplantation of Human Ovarian Tissue in the Forearm. Fertility And Sterility 2000, 74: s90-s91. DOI: 10.1016/s0015-0282(00)00967-5.Peer-Reviewed Original ResearchTransplantation of cryopreserved human ovarian tissue results in follicle growth initiation in SCID mice
Oktay K, Newton H, Gosden R. Transplantation of cryopreserved human ovarian tissue results in follicle growth initiation in SCID mice. Fertility And Sterility 2000, 73: 599-603. PMID: 10689020, DOI: 10.1016/s0015-0282(99)00548-8.Peer-Reviewed Original ResearchConceptsOvarian tissueSCID miceFrozen-thawed human ovarian tissueFrozen-thawed ovarian tissueAutologous ovarian transplantationFrozen-thawed graftsHuman ovarian tissueFollicle growth initiationLong-term survivalWeeks of graftingHuman primordial folliclesFollicle countOvarian transplantationImmunodeficiency miceMAIN OUTCOMEHealthy folliclesPrimordial folliclesAcademic centersAnimal studiesFollicle stageAdvanced folliclesFolliclesGraftMiceNecrotic cells
1998
Development of human primordial follicles to antral stages in SCID/hpg mice stimulated with follicle stimulating hormone.
Oktay K, Newton H, Mullan J, Gosden R. Development of human primordial follicles to antral stages in SCID/hpg mice stimulated with follicle stimulating hormone. Human Reproduction 1998, 13: 1133-1138. PMID: 9647533, DOI: 10.1093/humrep/13.5.1133.Peer-Reviewed Original ResearchConceptsWeeks of graftingSevere combined immunodeficiencyFollicle growthOvarian xenograftsAntral stageOestradiol levelsLong-term graftHuman ovarian xenograftsHuman follicle developmentHuman ovarian tissueOvarian follicular growthPreantral follicle growthLong-term graftingGranulosa cell layerHuman primordial folliclesCell nuclear antigenFSH administrationHpg miceKidney capsuleGonadotrophin stimulationRenal capsuleHuman ovaryImmunodeficient miceFollicular growthSmall follicles
1997
Isolation and characterization of primordial follicles from fresh and cryopreserved human ovarian tissue
Oktay K, Nugent D, Newton H, Salha O, Chatterjee P, Gosden R. Isolation and characterization of primordial follicles from fresh and cryopreserved human ovarian tissue. Fertility And Sterility 1997, 67: 481-486. PMID: 9091334, DOI: 10.1016/s0015-0282(97)80073-8.Peer-Reviewed Original ResearchConceptsHuman ovarian tissuePrimordial folliclesOvarian tissueWhole folliclesElective cesarean sectionLeeds General InfirmaryCryopreserved ovarian tissueHuman primordial folliclesCesarean sectionHealthy womenOvarian biopsyFollicle countingGeneral InfirmaryMAIN OUTCOMEFollicle viabilityUltrastructural signsFrozen-thawed groupFolliclesFresh groupTissuePropidium iodideSuccinimidyl esterViability ratePercent viabilityOocytes