2024
Associations between Social Adversity and Biomarkers of Inflammation, Stress, and Aging in Children
Pantell M, Silveira P, de Mendonça Filho E, Wing H, Brown E, Keeton V, Pokhvisneva I, O’Donnell K, Neuhaus J, Hessler D, Meaney M, Adler N, Gottlieb L. Associations between Social Adversity and Biomarkers of Inflammation, Stress, and Aging in Children. Pediatric Research 2024, 95: 1553-1563. PMID: 38233512, PMCID: PMC11126389, DOI: 10.1038/s41390-023-02992-6.Peer-Reviewed Original ResearchSocial adversityChildhood social adversityBiomarkers of inflammationEpigenetic ageSocial risk factorsChildren aged 0ResultsOur final sampleCytokine clusterCumulative adversityFinal sampleSocial predictorsPediatric clinicAged 0Logistic regressionNeuroendocrine functionBiomarkers of stressRisk factorsImpactOur studySocial factorsU-shaped distributionAdversityAssociationBiomarker samplingChildhoodChildren
2021
Salivary cytokine cluster moderates the association between caregivers perceived stress and emotional functioning in youth
Parent C, Pokhvisneva I, de Mendonça Filho EJ, O'Donnell KJ, Meaney MJ, Kee MZL, Thng G, Wing H, Adler NE, Keeton V, Pantell MS, Hessler D, Gottlieb LM, Silveira PP. Salivary cytokine cluster moderates the association between caregivers perceived stress and emotional functioning in youth. Brain Behavior And Immunity 2021, 94: 125-137. PMID: 33662503, DOI: 10.1016/j.bbi.2021.02.025.Peer-Reviewed Original ResearchConceptsCaregivers' perceived stressIL-1βIL-6Cytokine clusterChild Behavior ChecklistEmotional functioningIL-8 cytokine levelsChild emotional functioningPediatric clinic visitsProspective birth cohortHyperactivity problemsEarly life stressPerceived stressPotential intergenerational effectsUCSF cohortSystemic inflammationClinic visitsCytokine levelsInflammation levelsSalivary levelsAttention Deficit Hyperactivity ProblemsIL-8Pediatric QualityLife InventoryBirth cohort