Featured Publications
Trophoblast inclusions in the human placenta: Identification, characterization, quantification, and interrelations of subtypes
Kliman HJ, Firestein MR, Hofmann KM, Milano KM, Holzer PH, Brink LT, Odendaal HJ, Fifer WP. Trophoblast inclusions in the human placenta: Identification, characterization, quantification, and interrelations of subtypes. Placenta 2020, 103: 172-176. PMID: 33152642, PMCID: PMC8448462, DOI: 10.1016/j.placenta.2020.10.014.Peer-Reviewed Original Research
2023
Progress on the Endometrium
Frankfurter D, Kliman H. Progress on the Endometrium. Obstetrics And Gynecology Clinics Of North America 2023, 50: 677-694. PMID: 37914487, DOI: 10.1016/j.ogc.2023.09.002.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsEmbryo ImplantationEndometriosisEndometriumFemaleHumansMammalsPregnancyTrophoblastsUterusConceptsAbsence of pregnancyEvidence-based approachEndometrial assessmentStromal maturationEndometrial proliferationEndometrial pathologyInflammatory mediatorsOvarian steroidsImplantation failureBlastocyst implantationEndometrial sloughingDiagnostic measuresEndometriumOffer hopeDynamic tissueDevelopmental markersSingle testTissueInternal reproductionMaturationEndometriosisPregnancyDecidualizationInfertilityUterus
2022
Trophoblast inclusions and adverse birth outcomes
Firestein MR, Kliman HJ, Sania A, Brink LT, Holzer PH, Hofmann KM, Milano KM, Pini N, Shuffrey LC, Odendaal HJ, Fifer WP. Trophoblast inclusions and adverse birth outcomes. PLOS ONE 2022, 17: e0264733. PMID: 35231069, PMCID: PMC8887719, DOI: 10.1371/journal.pone.0264733.Peer-Reviewed Original ResearchConceptsBirth outcomesGestational ageLiveborn deliveryLive birthsFull-term live birthsChorionic villiPreterm live birthsSpecific placental pathologyFull-term birthInduction of laborAdverse birth outcomesGestational age birthweightSafe Passage StudyTrophoblast inclusionsGreater odds ratioWarrants further investigationPlacental infarctionPlacenta accretaPreterm birthPlacental pathologyVillous edemaPatient populationAlcohol exposureOdds ratioChorionic plate
2021
Genetics, not the uterine environment, drive the formation of trophoblast inclusions: Insights from a twin study
Katz J, Holzer PH, Kliman HJ. Genetics, not the uterine environment, drive the formation of trophoblast inclusions: Insights from a twin study. Placenta 2021, 114: 133-138. PMID: 33941390, DOI: 10.1016/j.placenta.2021.04.010.Peer-Reviewed Original ResearchMeSH KeywordsAneuploidyDiseases in TwinsFemaleFetal DiseasesHumansMalePlacentaPregnancyRetrospective StudiesTrophoblastsConceptsMean differenceUterine environmentTwin pairsTrophoblast inclusionsRetrospective case seriesCase seriesPregnancy lossIntrauterine environmentFetal geneticsMZ twinsDZ twinsDizygotic twin pairsMZ twin pairsGenetic abnormalitiesPlacentaZygosity groupsTwin individualsAverage numberMonozygoticTwin studiesMean absolute differenceAbsolute differenceDifferencesGroupFetuses
2018
Pathway of Maternal Serotonin to the Human Embryo and Fetus
Kliman HJ, Quaratella SB, Setaro AC, Siegman EC, Subha ZT, Tal R, Milano KM, Steck TL. Pathway of Maternal Serotonin to the Human Embryo and Fetus. Endocrinology 2018, 159: 1609-1629. PMID: 29381782, DOI: 10.1210/en.2017-03025.Peer-Reviewed Original ResearchAnimalsATP Binding Cassette Transporter, Subfamily B, Member 1Connexin 43FemaleFetusHumansMaternal-Fetal ExchangeMiceMonoamine OxidaseOctamer Transcription Factor-3PlacentaPregnancyPregnancy Trimester, FirstPregnancy Trimester, SecondSerotoninSerotonin Plasma Membrane Transport ProteinsTrophoblastsTryptophan Hydroxylase
2013
Trophoblast Inclusions Are Significantly Increased in the Placentas of Children in Families at Risk for Autism
Walker CK, Anderson KW, Milano KM, Ye S, Tancredi DJ, Pessah IN, Hertz-Picciotto I, Kliman HJ. Trophoblast Inclusions Are Significantly Increased in the Placentas of Children in Families at Risk for Autism. Biological Psychiatry 2013, 74: 204-211. PMID: 23623455, PMCID: PMC3755347, DOI: 10.1016/j.biopsych.2013.03.006.Peer-Reviewed Original ResearchConceptsElevated riskPlacentas of childrenTrophoblast inclusionsUncomplicated term pregnanciesAutism spectrum disorderPositive likelihood ratioTargeted early interventionsNeurodevelopmental compromiseMultiparous womenTerm pregnancyRisk pregnanciesBiological childrenControl placentasBehavioral symptomsEarly interventionNeurodevelopmental vulnerabilityPlacentaCritical windowRisk statusPregnancyRiskNewbornsChildrenDevelopmental outcomesControl samples
2012
Placental Protein 13 and Decidual Zones of Necrosis: An Immunologic Diversion That May be Linked to Preeclampsia
Kliman HJ, Sammar M, Grimpel YI, Lynch SK, Milano KM, Pick E, Bejar J, Arad A, Lee JJ, Meiri H, Gonen R. Placental Protein 13 and Decidual Zones of Necrosis: An Immunologic Diversion That May be Linked to Preeclampsia. Reproductive Sciences 2012, 19: 16-30. PMID: 21989657, DOI: 10.1177/1933719111424445.Peer-Reviewed Original ResearchConceptsPlacental protein 13Spiral arteriolesImmune cellsDecidual zoneProtein 13Decidual spiral arteriolesMaternal immune cellsWeeks of gestationElective pregnancy terminationHuman placental lactogenMaternal spiral arteriolesDecidual necrosisPregnancy terminationT cellsImmunohistochemical analysisDecidual veinsIntervillus spacePlacental lactogenInvasive trophoblastApoptosis markersPP13Chorionic villiNecrosisTrophoblastArterioles
2008
IFPA Meeting 2008 Workshops Report
Lash GE, Ansari T, Bischof P, Burton GJ, Chamley L, Crocker I, Dantzer V, Desoye G, Drewlo S, Fazleabas A, Jansson T, Keating S, Kliman HJ, Lang I, Mayhew T, Meiri H, Miller RK, Nelson DM, Pfarrer C, Roberts C, Sammar M, Sharma S, Shiverick K, Strunk D, Turner MA, Huppertz B. IFPA Meeting 2008 Workshops Report. Placenta 2008, 30: 4-14. PMID: 19084270, PMCID: PMC2668143, DOI: 10.1016/j.placenta.2008.11.014.Peer-Reviewed Original ResearchConceptsPlacental mesenchymal stem cellsIFPA annual meetingPlacental toxicologyPlacental pathologyPlacental transportTrophoblast subpopulationsMesenchymal stem cellsThemed workshopsStem cellsPlacentationFatty acidsInvasionWorkshop reportAnnual MeetingReportComparative placentationNeoplasiaPathologyTrophoblastImmunology
2006
Placental Trophoblast Inclusions in Autism Spectrum Disorder
Anderson GM, Jacobs-Stannard A, Chawarska K, Volkmar FR, Kliman HJ. Placental Trophoblast Inclusions in Autism Spectrum Disorder. Biological Psychiatry 2006, 61: 487-491. PMID: 16806106, DOI: 10.1016/j.biopsych.2006.03.068.Peer-Reviewed Original Research
2003
The placenta may predict the baby
Kliman HJ, Segel L. The placenta may predict the baby. Journal Of Theoretical Biology 2003, 225: 143-145. PMID: 14559066, DOI: 10.1016/s0022-5193(03)00248-0.Peer-Reviewed Original Research
2000
Uteroplacental Blood Flow The Story of Decidualization, Menstruation, and Trophoblast Invasion
Kliman H. Uteroplacental Blood Flow The Story of Decidualization, Menstruation, and Trophoblast Invasion. American Journal Of Pathology 2000, 157: 1759-1768. PMID: 11106547, PMCID: PMC1885765, DOI: 10.1016/s0002-9440(10)64813-4.Peer-Reviewed Original Research
1996
The effect of leukemia inhibitory factor (LIF) on trophoblast differentiation: a potential role in human implantation
Nachtigall MJ, Kliman HJ, Feinberg RF, Olive DL, Engin O, Arici A. The effect of leukemia inhibitory factor (LIF) on trophoblast differentiation: a potential role in human implantation. The Journal Of Clinical Endocrinology & Metabolism 1996, 81: 801-806. PMID: 8636307, DOI: 10.1210/jcem.81.2.8636307.Peer-Reviewed Original ResearchMeSH KeywordsBlotting, NorthernCell DifferentiationCells, CulturedChorionic GonadotropinChorionic Gonadotropin, beta Subunit, HumanEmbryo ImplantationFemaleFibronectinsGene ExpressionGrowth InhibitorsHumansInterleukin-6Leukemia Inhibitory FactorLymphokinesPregnancyProgesteroneRNA, MessengerTrophoblastsConceptsLeukemia inhibitory factorHuman cytotrophoblastsMenstrual cycle-dependent mannerInhibitory factorOncofetal fibronectinEffects of LIFHuman implantationHuman embryonic implantationBeta-HCG mRNAOncofetal fibronectin mRNAMessenger RNA expressionExtravillous phenotypeBeta-hCGMenstrual cycleHuman endometriumNormal implantationEmbryonic implantationProgesterone productionHCG mRNATerm placentaBiochemical markersCultured trophoblastsHuman CGDay 19Steroidogenic activity
1995
Monoclonal antibody X18A4 identifies on oncofetal fibronectin epitope distinct from the FDC-6 binding site
Feinberg R, Kliman H, Bedian V, Monzon-Bordonaba F, Menzin A, Wang C. Monoclonal antibody X18A4 identifies on oncofetal fibronectin epitope distinct from the FDC-6 binding site. American Journal Of Obstetrics And Gynecology 1995, 172: 1526-1536. PMID: 7538728, DOI: 10.1016/0002-9378(95)90491-3.Peer-Reviewed Original ResearchConceptsFDC-6Oncofetal fibronectinSimilar immunohistochemical stainingOvarian epithelial tumorsImmunoblot analysisTrophoblastic implantationPreterm laborSpecific monoclonal antibodiesEpithelial tumorsSpliced type IIIImmunohistochemical stainingNovel epitopesPlacental tissueAbnormal releaseVaginal secretionsCultured trophoblastsNew epitopesDistinct epitopesDetectable binding activityImmunosorbent assayMonoclonal antibodiesAntibodiesEpitopesType IIIComparative immunoassayFirst-trimester endocervical irrigation: feasibility of obtaining trophoblast cells for prenatal diagnosis.
Bahado-Singh RO, Kliman H, Feng TY, Hobbins J, Copel JA, Mahoney MJ. First-trimester endocervical irrigation: feasibility of obtaining trophoblast cells for prenatal diagnosis. Obstetrics And Gynecology 1995, 85: 461-4. PMID: 7862393, DOI: 10.1016/0029-7844(94)00416-b.Peer-Reviewed Original ResearchConceptsTrophoblast cellsPrenatal diagnosisInternal cervical osElective pregnancy terminationFirst trimester diagnosisPlacental pathologistPregnant patientsWeeks' gestationCervical osNormal salinePregnancy terminationUltrasound guidanceAdditional casesPlastic catheterDiagnosisFirst-trimester prenatal diagnosisBrief durationGestationHCG antibodySignificant percentageFurther testingCellsLight microscopyTechnical simplicityPatients
1994
Transforming growth factor-beta stimulates trophoblast oncofetal fibronectin synthesis in vitro: implications for trophoblast implantation in vivo
Feinberg RF, Kliman HJ, Wang CL. Transforming growth factor-beta stimulates trophoblast oncofetal fibronectin synthesis in vitro: implications for trophoblast implantation in vivo. The Journal Of Clinical Endocrinology & Metabolism 1994, 78: 1241-1248. PMID: 8175984, DOI: 10.1210/jcem.78.5.8175984.Peer-Reviewed Original ResearchConceptsTGF beta 1TGF betaBeta 1Ability of trophoblastsAnti-TGF betaSevere alloimmune thrombocytopeniaThird trimester placentasPlatelet-poor serumDose-response analysisPregnancy tissueCord serumAlloimmune thrombocytopeniaCytokine presentUterine deciduaExtracellular matrixVillous syncytiotrophoblastTrimester placentaNormal serumHuman cytotrophoblastsGrowth factor-beta stimulatesOncofetal fibronectinNormal morphological differentiationCulture secreteStimulatory responseThrombocytopenic serum
1993
The placenta revealed.
Kliman HJ. The placenta revealed. American Journal Of Pathology 1993, 143: 332-6. PMID: 8342590, PMCID: PMC1887036.Peer-Reviewed Original Research
1992
Fetal Fibronectin and Preterm Labor
Feinberg RF, Kliman HJ. Fetal Fibronectin and Preterm Labor. New England Journal Of Medicine 1992, 326: 708-709. PMID: 1736115, DOI: 10.1056/nejm199203053261013.Peer-Reviewed Original Research
1991
In Vitro Systems for the Study of Human Trophoblast Implantation
COUTIFARIS C, BABALOLA GO, ABISOGUN AO, KAO L, CHIN U, VADILLO‐ORTEGA F, OSHEROFF J, KLIMAN HJ, STRAUSS JF. In Vitro Systems for the Study of Human Trophoblast Implantation. Annals Of The New York Academy Of Sciences 1991, 622: 191-201. PMID: 2064180, DOI: 10.1111/j.1749-6632.1991.tb37862.x.Peer-Reviewed Original ResearchIs oncofetal fibronectin a trophoblast glue for human implantation?
Feinberg RF, Kliman HJ, Lockwood CJ. Is oncofetal fibronectin a trophoblast glue for human implantation? American Journal Of Pathology 1991, 138: 537-43. PMID: 2000933, PMCID: PMC1886265.Peer-Reviewed Original Research
1990
Human trophoblast-endometrial interactions in an in vitro suspension culture system
Kliman H, Feinberg R, Haimowitz J. Human trophoblast-endometrial interactions in an in vitro suspension culture system. Placenta 1990, 11: 349-367. PMID: 2235916, DOI: 10.1016/s0143-4004(05)80226-7.Peer-Reviewed Original Research