2023
AMH predicts miscarriage in non-PCOS but not in PCOS related infertility ART cycles
Arkfeld C, Han E, Tal R, Seifer D. AMH predicts miscarriage in non-PCOS but not in PCOS related infertility ART cycles. Reproductive Biology And Endocrinology 2023, 21: 35. PMID: 37020210, PMCID: PMC10074664, DOI: 10.1186/s12958-023-01087-5.Peer-Reviewed Original ResearchConceptsBody mass indexMiscarriage rateMean AMHART cyclesNumber of embryosElevated AMHAMH valuesOdds ratioNon-PCOS patientsOverall miscarriage rateConfidence intervalsAutologous embryo transferSART CORS databaseMultivariate regression analysisHeterotopic pregnancyClinical pregnancyAMH levelsIVF cyclesPCOS patientsPCOS populationIndependent predictorsMass indexPatient populationOocyte bankingAutologous transferAMH independently predicts aneuploidy but not live birth per transfer in IVF PGT-A cycles
Li H, Seifer D, Tal R. AMH independently predicts aneuploidy but not live birth per transfer in IVF PGT-A cycles. Reproductive Biology And Endocrinology 2023, 21: 19. PMID: 36739415, PMCID: PMC9898926, DOI: 10.1186/s12958-023-01066-w.Peer-Reviewed Original ResearchConceptsAnti-Müllerian hormoneNumber of embryosEuploid embryosLive birthsOocyte qualityAge groupsSignificant independent predictorsCase-control analysisSART CORS databasePreimplantation genetic testingAMH levelsIVF cyclesIndependent predictorsIVF outcomesOocyte yieldNormal embryosPredictive roleGenetic testingFinal analysisBirthAgeIVFSubset of cyclesHormonePGT
2022
The Role of Angiogenic Factor Dysregulation in the Pathogenesis of Polycystic Ovarian Syndrome
Chen A, Seifer D, Tal R. The Role of Angiogenic Factor Dysregulation in the Pathogenesis of Polycystic Ovarian Syndrome. 2022, 449-487. DOI: 10.1007/978-3-030-92589-5_23.Peer-Reviewed Original ResearchPolycystic ovarian syndromeOvulatory dysfunctionGrowth factorOvarian syndromePathophysiology of PCOSAngiogenic factorsAbnormal endometrial receptivityPCOS animal modelsOvarian hyperstimulation syndromeReproductive-age womenMenstrual cycle functionVascular endothelial growth factorNormal follicular developmentComplex endocrine disorderPlatelet-derived growth factorBasic fibroblast growth factorEndothelial growth factorFibroblast growth factorAngiogenesis dysfunctionHyperstimulation syndromeAngiogenic imbalancePCOS patientsPCOS managementPolycystic ovariesAngiogenesis-based therapies
2021
AMH Highly Correlates With Cumulative Live Birth Rate in Women with Diminished Ovarian Reserve Independent of Age*
Tal R, Seifer DB, Tal R, Granger E, Wantman E, Tal O. AMH Highly Correlates With Cumulative Live Birth Rate in Women with Diminished Ovarian Reserve Independent of Age*. The Journal Of Clinical Endocrinology & Metabolism 2021, 106: 2754-2766. PMID: 33729496, DOI: 10.1210/clinem/dgab168.Peer-Reviewed Original ResearchConceptsCumulative live birth rateDiminished ovarian reserveLive birth rateSerum AMHLive birthsAge strataRetrieval cycleAntimüllerian hormone levelsReproductive technology cyclesCumulative live birthMain outcome measuresMultiple logistic regressionNumber of oocytesBirth rateRegression analysisPreimplantation genetic testingAddition of AMHPercentage of cyclesOvarian reserveIndependent predictorsOvarian responseHormone levelsRetrospective analysisOutcome measuresEmbryo transfer
2019
Assessment of Ovarian Reserve
Nelson S, Tal R, Seifer D. Assessment of Ovarian Reserve. 2019, 36-48. DOI: 10.1017/9781316756744.003.ChaptersChapter 25 The Role of Antimullerian Hormone in Assisted Reproduction
Tal R, Seifer D. Chapter 25 The Role of Antimullerian Hormone in Assisted Reproduction. 2019, 403-414. DOI: 10.1016/b978-0-12-813209-8.00025-x.ChaptersAntimullerian hormoneOvarian responseControlled ovarian stimulationOnset of menopausePrimordial follicle poolInformative biochemical markersOvarian stimulationOvarian reserveFertility preservationAbnormal folliculogenesisFollicle poolClinical utilityParacrine regulatorSensitive markerStimulation protocolChronologic ageOvarian folliclesGranulosa cellsBiochemical markersReproductive agingReproductive medicineInverse correlationAssisted reproductionReproductive technologiesClinical application
2018
Antimüllerian hormone as a predictor of live birth following assisted reproduction: an analysis of 85,062 fresh and thawed cycles from the Society for Assisted Reproductive Technology Clinic Outcome Reporting System database for 2012–2013
Tal R, Seifer DB, Wantman E, Baker V, Tal O. Antimüllerian hormone as a predictor of live birth following assisted reproduction: an analysis of 85,062 fresh and thawed cycles from the Society for Assisted Reproductive Technology Clinic Outcome Reporting System database for 2012–2013. Fertility And Sterility 2018, 109: 258-265. PMID: 29331235, DOI: 10.1016/j.fertnstert.2017.10.021.Peer-Reviewed Original ResearchAdultAnti-Mullerian HormoneArea Under CurveBiomarkersChi-Square DistributionCryopreservationDatabases, FactualEmbryo TransferFemaleFertilization in VitroHumansInfertilityLive BirthLogistic ModelsMaleOdds RatioPregnancyPregnancy RateRetrospective StudiesRisk FactorsROC CurveSingle Embryo TransferTime FactorsTreatment Outcome
2017
Ovarian reserve testing: a user’s guide
Tal R, Seifer DB. Ovarian reserve testing: a user’s guide. American Journal Of Obstetrics And Gynecology 2017, 217: 129-140. PMID: 28235465, DOI: 10.1016/j.ajog.2017.02.027.Peer-Reviewed Original ResearchConceptsOvarian reserve testingOvarian reserve testsOvarian reserveAntimüllerian hormoneDay 3 follicle-stimulating hormonePolycystic ovary syndromeFemale cancer patientsFollicle-stimulating hormoneFertility treatment optionsSelection of treatmentAntral follicular countAge-specific valuesGood predictive valueComplex clinical phenomenonOvarian hyperstimulationOvarian stimulationOvary syndromeGonadotoxic therapyTreatment optionsCancer patientsPoor responseReproductive ageFollicular countReproductive endocrinologistsTreatment protocol
2015
Vitamin D Supplementation Decreases TGF-β1 Bioavailability in PCOS: A Randomized Placebo-Controlled Trial
Irani M, Seifer DB, Grazi RV, Julka N, Bhatt D, Kalgi B, Irani S, Tal O, Lambert-Messerlian G, Tal R. Vitamin D Supplementation Decreases TGF-β1 Bioavailability in PCOS: A Randomized Placebo-Controlled Trial. The Journal Of Clinical Endocrinology & Metabolism 2015, 100: 4307-4314. PMID: 26485217, DOI: 10.1210/jc.2015-2580.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAntigens, CDBiological AvailabilityCholecalciferolDehydroepiandrosterone SulfateEndoglinFemaleHumansInsulin ResistanceLipidsPolycystic Ovary SyndromeProspective StudiesReceptors, Cell SurfaceSocioeconomic FactorsTestosteroneTransforming Growth Factor beta1Vitamin DVitamin D DeficiencyVitaminsYoung AdultConceptsPolycystic ovary syndromeVD supplementationTGF-β1Clinical manifestationsClinical parametersAcademic-affiliated medical centerFerriman-Gallwey scoreOral vitamin D3Serum TGF-β1Soluble endoglin levelsPlacebo-controlled trialVitamin D supplementationTGF-β1 levelsNew treatment modalitiesD supplementationOral placeboRandomized PlaceboOvary syndromeVD levelsEndoglin levelsInsulin resistanceTreatment modalitiesMenstrual periodLipid profileVitamin D3The Emerging Role of Angiogenic Factor Dysregulation in the Pathogenesis of Polycystic Ovarian Syndrome
Tal R, Seifer DB, Arici A. The Emerging Role of Angiogenic Factor Dysregulation in the Pathogenesis of Polycystic Ovarian Syndrome. Seminars In Reproductive Medicine 2015, 33: 195-207. PMID: 26036901, DOI: 10.1055/s-0035-1552582.Peer-Reviewed Original ResearchConceptsPolycystic ovarian syndromeGrowth factorOvarian syndromePathophysiology of PCOSAngiogenic factor imbalanceOvarian hyperstimulation syndromeCommon endocrine disorderVascular endothelial growth factorPlatelet-derived growth factorBasic fibroblast growth factorMultiple angiogenic factorsEndothelial growth factorFibroblast growth factorHyperstimulation syndromeOvulatory dysfunctionStromal vascularityAnovulatory infertilityPolycystic ovariesEndocrine disordersReproductive ageTreatment strategiesFollicular growthOvarian angiogenesisAngiogenic factorsCorpus luteumAlpha-Fetoprotein as a Tool to Distinguish Amniotic Fluid From Urine, Vaginal Discharge, and Semen
Mor A, Tal R, Haberman S, McCalla S, Irani M, Perlman J, Seifer DB, Minkoff H. Alpha-Fetoprotein as a Tool to Distinguish Amniotic Fluid From Urine, Vaginal Discharge, and Semen. Obstetrics And Gynecology 2015, 125: 448-452. PMID: 25569004, DOI: 10.1097/aog.0000000000000635.Peer-Reviewed Original ResearchConceptsNormal vaginal dischargeAlpha-fetoprotein concentrationDiagnosis of ruptureVaginal dischargeAmniotic fluidAlpha-fetoproteinPregnant womenReceiver operator characteristic curve analysisSanitary padsOperator characteristic curve analysisProspective cohort studyAlpha-fetoprotein levelsAmniotic fluid levelsCharacteristic curve analysisAmniotic fluid specimensCohort studyInfertility evaluationMaternal urineAFP levelsFluid specimensFluid levelsSemen specimensCurve analysisUrineAFP quantification
2014
Antimüllerian hormone as predictor of implantation and clinical pregnancy after assisted conception: a systematic review and meta-analysis
Tal R, Tal O, Seifer BJ, Seifer DB. Antimüllerian hormone as predictor of implantation and clinical pregnancy after assisted conception: a systematic review and meta-analysis. Fertility And Sterility 2014, 103: 119-130.e3. PMID: 25450298, DOI: 10.1016/j.fertnstert.2014.09.041.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnti-Mullerian HormoneBiomarkersEmbryo ImplantationFemaleFertilization in VitroHumansInfertility, FemaleMiddle AgedObservational Studies as TopicOvarian ReserveOvaryOvulation InductionPregnancyPregnancy OutcomePregnancy RatePrevalenceReproducibility of ResultsRisk FactorsSensitivity and SpecificityYoung AdultConceptsPredictor of implantationClinical pregnancy rateAntimüllerian hormoneClinical pregnancyOvarian reservePregnancy rateOdds ratioIVF/intracytoplasmic sperm injectionSystematic reviewSerum AMH levelsPolycystic ovary syndromeReproductive technologiesIntracytoplasmic sperm injectionNondonor cyclesAMH levelsOvary syndromeImplantation rateDiagnostic odds ratioObservational studyMAIN OUTCOMEClinical utilitySperm injectionPregnancyAssisted conceptionFertility treatmentCharacterization of women with elevated antimüllerian hormone levels (AMH): correlation of AMH with polycystic ovarian syndrome phenotypes and assisted reproductive technology outcomes
Tal R, Seifer DB, Khanimov M, Malter HE, Grazi RV, Leader B. Characterization of women with elevated antimüllerian hormone levels (AMH): correlation of AMH with polycystic ovarian syndrome phenotypes and assisted reproductive technology outcomes. American Journal Of Obstetrics And Gynecology 2014, 211: 59.e1-59.e8. PMID: 24593938, DOI: 10.1016/j.ajog.2014.02.026.Peer-Reviewed Original ResearchConceptsSerum antimüllerian hormone levelsAntimüllerian hormone levelsClinical pregnancy ratePopulation of womenAMH levelsPregnancy rateHormone levelsHigher clinical pregnancy rateElevated AMH levelsPresence of amenorrheaMultiple pregnancy rateOvarian hyperstimulation syndromeRetrospective cohort studyHigher AMH levelsPolycystic ovarian morphologyPolycystic ovarian syndromeSyndrome phenotypeReproductive technology outcomesHyperstimulation syndromePCOS severityClinical pregnancyOvarian stimulationTotal testosteroneCohort studyOvarian syndrome
2013
Potential Mechanisms for Racial and Ethnic Differences in Antimüllerian Hormone and Ovarian Reserve
Tal R, Seifer DB. Potential Mechanisms for Racial and Ethnic Differences in Antimüllerian Hormone and Ovarian Reserve. International Journal Of Endocrinology 2013, 2013: 818912. PMID: 24348557, PMCID: PMC3857838, DOI: 10.1155/2013/818912.Peer-Reviewed Original ResearchOvarian reserveAntimüllerian hormoneRacial differencesSerum antimüllerian hormoneSerum AMH levelsVitamin D deficiencyReproductive technology treatmentEthnic differencesImportant clinical implicationsSuch racial differencesAMH levelsD deficiencyInfertility treatmentTreatment outcomesReproductive endocrinologistsReproductive planningEthnic groupsTimely interventionClinical implicationsReproductive agingSensitive biomarkerTechnology treatmentEthnic variationGenetic factorsPotential mechanismsReport of two cases of ovarian torsion after egg retrieval treated by laparoscopic detorsion followed by successful embryo transfer on day five
Irani M, Tal R, Seifer D, Grazi R. Report of two cases of ovarian torsion after egg retrieval treated by laparoscopic detorsion followed by successful embryo transfer on day five. Fertility And Sterility 2013, 100: s285-s286. DOI: 10.1016/j.fertnstert.2013.07.1068.Peer-Reviewed Original ResearchAngiopoietin-2 is increased in follicular fluid of polycystic ovarian syndrome (PCOS) women during controlled ovarian stimulation and correlates with number of oocytes retrieved
Tal R, Seifer D, Shohat-Tal A, Malter H, Grazi R. Angiopoietin-2 is increased in follicular fluid of polycystic ovarian syndrome (PCOS) women during controlled ovarian stimulation and correlates with number of oocytes retrieved. Fertility And Sterility 2013, 100: s360. DOI: 10.1016/j.fertnstert.2013.07.851.Peer-Reviewed Original ResearchDisparities Between Black and White Women in Assisted Reproductive Technology
Tal R, Seifer D. Disparities Between Black and White Women in Assisted Reproductive Technology. 2013, 73-83. DOI: 10.1007/978-1-4614-7548-4_5.ChaptersBlack race/ethnicityLower clinical pregnancyReproductive technologiesUS health care systemHealth care systemAssisted Reproductive TechnologyRace/ethnicityClinical pregnancyPoor outcomeLive birthrateSevere diseaseART outcomesWhite womenCare systemSocioeconomic statusGenetic factorsSuch disparitiesOutcomesPregnancyConfoundersDisparitiesDiseaseTransforming growth factor-β1 and its receptor soluble endoglin are altered in polycystic ovary syndrome during controlled ovarian stimulation
Tal R, Seifer DB, Shohat-Tal A, Grazi RV, Malter HE. Transforming growth factor-β1 and its receptor soluble endoglin are altered in polycystic ovary syndrome during controlled ovarian stimulation. Fertility And Sterility 2013, 100: 538-543. PMID: 23684116, DOI: 10.1016/j.fertnstert.2013.04.022.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntigens, CDCase-Control StudiesEndoglinFemaleFertilization in VitroFollicular FluidHumansInfertility, FemaleOvarian Hyperstimulation SyndromeOvulation InductionPolycystic Ovary SyndromeReceptors, Cell SurfaceSperm Injections, IntracytoplasmicTransforming Growth Factor beta1UltrasonographyYoung AdultConceptsPolycystic ovarian syndromeSerum soluble endoglinDay of hCGSoluble endoglinFollicular fluidTGF-β1Oocyte retrievalOvarian stimulationHCG administrationControl womenDay 3Pathogenesis of PCOSNon-PCOS control groupProspective case-control studyNon-PCOS controlsSerum TGF-β1Non-PCOS womenPolycystic ovary syndromeTGF-β1 levelsReproductive technology unitCase-control studyGrowth factor-β1Day of retrievalOvarian hyperstimulationOvarian syndrome
2012
Preeclampsia-associated soluble endoglin (sENG) is decreased in polycystic ovarian syndrome (PCOS) leading to transforming growth factor (TGF)-B1 dysregulation during controlled ovarian stimulation
Tal R, Seifer D, Shohat-Tal A, Grazi R, Malter H. Preeclampsia-associated soluble endoglin (sENG) is decreased in polycystic ovarian syndrome (PCOS) leading to transforming growth factor (TGF)-B1 dysregulation during controlled ovarian stimulation. Fertility And Sterility 2012, 98: s84. DOI: 10.1016/j.fertnstert.2012.07.304.Peer-Reviewed Original Research