2005
Müllerian inhibiting substance levels at the time of HCG administration in IVF cycles predict both ovarian reserve and embryo morphology
Silberstein T, MacLaughlin DT, Shai I, Trimarchi JR, Lambert-Messerlian G, Seifer DB, Keefe DL, Blazar AS. Müllerian inhibiting substance levels at the time of HCG administration in IVF cycles predict both ovarian reserve and embryo morphology. Human Reproduction 2005, 21: 159-163. PMID: 16123085, DOI: 10.1093/humrep/dei270.Peer-Reviewed Original ResearchMeSH KeywordsAnti-Mullerian HormoneChorionic GonadotropinEmbryo, MammalianFemaleFertilization in VitroGlycoproteinsHumansOvaryPrognosisTesticular HormonesTreatment OutcomeConceptsBasal FSH levelsOvarian reserveFSH levelsHCG administrationMIS levelsIVF outcomesOocyte qualityDay 3 FSH levelsMI levelsImproved oocyte qualityTime of hCGClinical pregnancy rateManagement of patientsSerum estradiol levelsHigher implantation rateEmbryo morphologyEmbryo morphology scoreNumber of oocytesEarly antral folliclesEnzyme-linked immunosorbentIVF cyclesOocyte retrievalPatient ageEstradiol levelsImplantation rate
2003
Effect of gonadotropins on brain-derived neurotrophic factor secretion by human follicular cumulus cells
Feng B, Chen S, Shelden RM, Seifer DB. Effect of gonadotropins on brain-derived neurotrophic factor secretion by human follicular cumulus cells. Fertility And Sterility 2003, 80: 658-659. PMID: 12969721, DOI: 10.1016/s0015-0282(03)00742-8.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrain-Derived Neurotrophic FactorChorionic GonadotropinFemaleFollicle Stimulating HormoneGranulosa CellsHumansLuteinizing Hormone
2000
Progesterone, Inhibin, and hCG Multiple Marker Strategy to Differentiate Viable From Nonviable Pregnancies
PHIPPS M, HOGAN J, PEIPERT J, LAMBERT-MESSERLIAN G, CANICK J, SEIFER D. Progesterone, Inhibin, and hCG Multiple Marker Strategy to Differentiate Viable From Nonviable Pregnancies. Obstetrics And Gynecology 2000, 95: 227-231. DOI: 10.1097/00006250-200002000-00011.Peer-Reviewed Original ResearchMeSH KeywordsAdultBiomarkersChorionic GonadotropinChorionic Gonadotropin, beta Subunit, HumanCohort StudiesFemaleFetal ViabilityHumansInhibinsPredictive Value of TestsPregnancyPregnancy ComplicationsPregnancy OutcomePregnancy Trimester, FirstProgesteroneProspective StudiesROC CurveSensitivity and SpecificityConceptsDual-biomarker strategyMultiple biomarker strategyNonviable pregnanciesSerum progesteroneBiomarker strategiesComplaints of painProspective cohort studySymptomatic pregnant womenCombination of progesteroneCohort studyCombination of serumInhibin AUrine biomarkersFirst trimesterPregnant womenEarly gestationNonviable outcomesPregnancySingle biomarkerHCGProgesteroneSpecific biomarkersDiagnostic accuracySerum samplesBiomarkersProgesterone, inhibin, and hCG multiple marker strategy to differentiate viable from nonviable pregnancies.
Phipps M, Hogan J, Peipert J, Lambert-Messerlian G, Canick J, Seifer D. Progesterone, inhibin, and hCG multiple marker strategy to differentiate viable from nonviable pregnancies. Obstetrics And Gynecology 2000, 95: 227-31. PMID: 10674584, DOI: 10.1016/s0029-7844(99)00480-9.Peer-Reviewed Original ResearchMeSH KeywordsAdultBiomarkersChorionic GonadotropinChorionic Gonadotropin, beta Subunit, HumanCohort StudiesFemaleFetal ViabilityHumansInhibinsPredictive Value of TestsPregnancyPregnancy ComplicationsPregnancy OutcomePregnancy Trimester, FirstProgesteroneProspective StudiesROC CurveSensitivity and SpecificityConceptsDual-biomarker strategyMultiple biomarker strategyNonviable pregnanciesSerum progesteroneBiomarker strategiesComplaints of painProspective cohort studySymptomatic pregnant womenCombination of progesteroneCohort studyCombination of serumInhibin AUrine biomarkersFirst trimesterPregnant womenEarly gestationNonviable outcomesPregnancySingle biomarkerHCGProgesteroneSpecific biomarkersDiagnostic accuracySerum samplesBiomarkers
1997
Persistent ectopic pregnancy: an argument for heightened vigilance and patient compliance
Seifer D. Persistent ectopic pregnancy: an argument for heightened vigilance and patient compliance. Fertility And Sterility 1997, 68: 402-404. PMID: 9314904, DOI: 10.1016/s0015-0282(97)00271-9.Peer-Reviewed Original Research
1996
Serum inhibin levels are lower in ectopic than intrauterine spontaneously conceived pregnancies*†*Presented in part at the 42nd Annual Meeting of the Society for Gynecological Investigation, Chicago, Illinois, March 15 to 18, 1995.†Supported in part by Physician Scientist Award from National Institutes of Health, National Institute on Aging grant AG00566 (D.B.S.) and HD29164 (G.M.L.M., A.L.S.).
Seifer D, Lambert-Messerlian G, Canick J, Frishman G, Schneyer A. Serum inhibin levels are lower in ectopic than intrauterine spontaneously conceived pregnancies*†*Presented in part at the 42nd Annual Meeting of the Society for Gynecological Investigation, Chicago, Illinois, March 15 to 18, 1995.†Supported in part by Physician Scientist Award from National Institutes of Health, National Institute on Aging grant AG00566 (D.B.S.) and HD29164 (G.M.L.M., A.L.S.). Fertility And Sterility 1996, 65: 667-669. PMID: 8774307, DOI: 10.1016/s0015-0282(16)58174-6.Peer-Reviewed Original ResearchMeSH KeywordsCase-Control StudiesChorionic GonadotropinFemaleHumansInhibinsOsmolar ConcentrationPregnancyPregnancy, EctopicProgesteroneReference ValuesConceptsIntrauterine pregnancySerum inhibin concentrationsDimeric inhibinInhibin concentrationsTotal inhibinMaternal serumSerum samplesDimeric inhibin concentrationSingle intrauterine pregnancySerum inhibin levelsCase-control studyAcademic clinical practiceNational InstituteAlpha-inhibin subunitGynecological InvestigationInhibin levelsSonographic evidenceGestational ageInhibin subunitsWeek 8MAIN OUTCOMEClinical practiceInhibinEctopicWomenRelaxin secretion in in vitro fertilization pregnancies
Haning R, Goldsmith L, Seifer D, Wheeler C, Frishman G, Sarmento J, Weiss G. Relaxin secretion in in vitro fertilization pregnancies. American Journal Of Obstetrics And Gynecology 1996, 174: 233-240. PMID: 8572013, DOI: 10.1016/s0002-9378(96)70400-3.Peer-Reviewed Original ResearchMeSH KeywordsChorionic GonadotropinEmbryo TransferEstradiolFemaleFertilization in VitroHumansLinear ModelsPregnancyPregnancy, MultipleProgesteroneRelaxinTime FactorsConceptsHuman chorionic gonadotropinSecretion of relaxinChorionic gonadotropinCorpora luteaSerum estradiolSerum relaxinFunctional statusHuman chorionic gonadotropin (hCG) injectionOvarian hyperstimulation syndromeSerum of womenSecretion of steroidsSerum relaxin concentrationsFertilization pregnanciesHyperstimulation syndromePremature deliveryMultiple gestationsGonadotropin injectionRelaxin secretionMore injectionsRelaxin concentrationsProgesterone concentrationsMultiple linear regression analysisPregnancyGonadotropinSteroid concentrations
1994
Early and late presentation of the ovarian hyperstimulation syndrome: two distinct entities with different risk factors*
Lyons CA, Wheeler CA, Frishman GN, Hackett RJ, Seifer DB, Haning RV. Early and late presentation of the ovarian hyperstimulation syndrome: two distinct entities with different risk factors*. Human Reproduction 1994, 9: 792-799. PMID: 7929724, DOI: 10.1093/oxfordjournals.humrep.a138598.Peer-Reviewed Original ResearchConceptsLate ovarian hyperstimulation syndromeOvarian hyperstimulation syndromeSevere ovarian hyperstimulation syndromeNumber of oocytesHyperstimulation syndromeEarly ovarian hyperstimulation syndromePost-human chorionic gonadotrophinDifferent risk factorsStepwise logistic regressionSeries of casesDay-hCGMultiple gestationsClinical predictorsFertilization cyclesGestational sacEarly pregnancyLate presentationOestradiol concentrationsSerum concentrationsEgg retrievalRisk factorsHigh oestradiolAcute effectsChorionic gonadotrophinRetrospective analysisUrine hCG beta-subunit core fragment, a sensitive test for ectopic pregnancy
Cole LA, Kardana A, Seifer DB, Bohler HC. Urine hCG beta-subunit core fragment, a sensitive test for ectopic pregnancy. The Journal Of Clinical Endocrinology & Metabolism 1994, 78: 497-499. PMID: 7508952, DOI: 10.1210/jcem.78.2.7508952.Peer-Reviewed Original ResearchConceptsTubal pregnancyBeta-core fragmentEmergency roomIntrauterine pregnancyEctopic pregnancyPregnancy levelsUrine samplesNormal levelsNormal intrauterine pregnancyPregnancy serum samplesMicrograms/LPregnancy concentrationsHCG levelsNormal pregnancyAdditional patientsBeta immunoreactivityHCG testPregnancy samplesPregnancyMedian levelsPredictive valueHCGSerum samplesGlycoprotein hormonesSensitive test
1993
Selecting human chorionic gonadotropin immunoassays: Consideration of cross-reacting molecules in first-trimester pregnancy serum and urine
Cole L, Seifer D, Kardana A, Braunstein G. Selecting human chorionic gonadotropin immunoassays: Consideration of cross-reacting molecules in first-trimester pregnancy serum and urine. American Journal Of Obstetrics And Gynecology 1993, 168: 1580-1586. PMID: 8498446, DOI: 10.1016/s0002-9378(11)90802-3.Peer-Reviewed Original ResearchMeSH KeywordsChorionic GonadotropinCross ReactionsFemaleHumansImmunoassayPregnancyPregnancy Tests, ImmunologicPregnancy Trimester, FirstReagent Kits, DiagnosticConceptsHuman chorionic gonadotropinTotal human chorionic gonadotropin levelHuman chorionic gonadotropin levelsTotal human chorionic gonadotropinChorionic gonadotropin levelsChorionic gonadotropinGonadotropin levelsPregnancy serumFirst trimester pregnancy seraHuman chorionic gonadotropin resultsNicked human chorionic gonadotropinHuman chorionic gonadotropin immunoassaysFree beta subunitGonadotropin resultsEarly pregnancyCross-reacting moleculesHome test kitsPregnancy testBeta assaysGonadotropinMedian levelsDiscordant resultsDifferent commercial kitsSerum samplesFree beta
1992
Flow cytometric analysis of deoxyribonucleic acid in human granulosa cells as a function of chronological age and ovulation induction regimen
Seifer DB, Honig J, Penzias AS, Lavy G, Nadkarni PM, Jones EE, DeCherney AH, Flynn SD. Flow cytometric analysis of deoxyribonucleic acid in human granulosa cells as a function of chronological age and ovulation induction regimen. The Journal Of Clinical Endocrinology & Metabolism 1992, 75: 636-640. PMID: 1639962, DOI: 10.1210/jcem.75.2.1639962.Peer-Reviewed Original ResearchConceptsHuman menopausal gonadotropinOvulation induction regimenGreater proliferative indexInduction regimenLeuprolide acetateProliferative indexGranulosa cellsGroup IGroup IIGroup IIIAmpules of hMGFunction of ageFlow cytometryDay of hCGProspective cohort studyGroup of patientsHuman granulosa cellsChronological ageMenopausal gonadotropinCohort studyOvulation inductionSerum FSHSignificant independent influenceOutcome measuresWomen's ageLuteinizing response to human chorionic gonadotropin does not predict outcome in gonadotropin releasing hormone agonist-suppressed/human menopausal gonadotropin-stimulated in vitro fertilization (IVF) cycles
Penzias A, Shamma F, Gutmann J, Seifer D, DeCherney A, Lavy G. Luteinizing response to human chorionic gonadotropin does not predict outcome in gonadotropin releasing hormone agonist-suppressed/human menopausal gonadotropin-stimulated in vitro fertilization (IVF) cycles. Journal Of Assisted Reproduction And Genetics 1992, 9: 244-247. PMID: 1525454, DOI: 10.1007/bf01203821.Peer-Reviewed Original ResearchBaseline ovarian cysts do not affect clinical response to controlled ovarian hyperstimulation for in vitro fertilization**Presented at the 47th Annual Meeting of The American Fertility Society, Orlando, Florida, October 21 to 24, 1991.
Penzias A, Jones E, Seifer D, Grifo J, Thatcher S, DeCherney A. Baseline ovarian cysts do not affect clinical response to controlled ovarian hyperstimulation for in vitro fertilization**Presented at the 47th Annual Meeting of The American Fertility Society, Orlando, Florida, October 21 to 24, 1991. Fertility And Sterility 1992, 57: 1017-1021. PMID: 1572468, DOI: 10.1016/s0015-0282(16)55019-5.Peer-Reviewed Original ResearchConceptsBaseline ovarian cystsNumber of folliclesOvarian cystsOvarian hyperstimulationIVF cyclesClinical responseStimulation regimenBaseline E2 levelBaseline serum estradiolCycle cancellation ratePeak serum E2Vitro Fertilization ProgramAmerican Fertility SocietyNumber of oocytesSerum E2Serum estradiolNumber of cystsCycle outcomeE2 levelsCyst sizeFertility SocietySuch cystsCancellation rateYale University SchoolOwn control
1991
Early pituitary desensitization and ovarian suppression with leuprolide acetate is associated with in vitro fertilization-embryo transfer success**Presented in part at the Society for Gynecologic Investigation, San Antonio, Texas, March 20 to 23, 1991.
Seifer D, Thornton K, DeCherney A, Lavy G. Early pituitary desensitization and ovarian suppression with leuprolide acetate is associated with in vitro fertilization-embryo transfer success**Presented in part at the Society for Gynecologic Investigation, San Antonio, Texas, March 20 to 23, 1991. Fertility And Sterility 1991, 56: 500-504. PMID: 1909977, DOI: 10.1016/s0015-0282(16)54548-8.Peer-Reviewed Original ResearchConceptsLeuprolide acetatePituitary desensitizationOvarian suppressionPregnancy ratePg/Group IOvarian hyperstimulationIVF-ETE2 responseGroup IIHuman menopausal gonadotropinControlled ovarian hyperstimulationFertilization-embryo transferSerum estradiol levelsNumber of oocytesHuman chorionic gonadotropinHigher pregnancy ratePg/mLMenopausal gonadotropinIVF patientsRetrospective seriesEstradiol levelsGynecologic InvestigationInfertility practiceMenstrual cycleInduction of Ovulation for IVF and Its Effect on the Luteal Phase
DOYLE M, THORNTON K, SEIFER D, DECHERNEY A. Induction of Ovulation for IVF and Its Effect on the Luteal Phase. Annals Of The New York Academy Of Sciences 1991, 626: 217-227. PMID: 2058956, DOI: 10.1111/j.1749-6632.1991.tb37917.x.Peer-Reviewed Original Research
1990
Persistent ectopic pregnancy following laparoscopic linear salpingostomy.
Seifer DB, Gutmann JN, Doyle MB, Jones EE, Diamond MP, DeCherney AH. Persistent ectopic pregnancy following laparoscopic linear salpingostomy. Obstetrics And Gynecology 1990, 76: 1121-5. PMID: 1700350.Peer-Reviewed Original ResearchConceptsPersistent ectopic pregnancyEctopic pregnancyLaparoscopic salpingostomyMultivariate stepwise logistic regressionYale-New Haven HospitalBeta-hCG titersClose postoperative surveillanceLaparoscopic linear salpingostomyDays of amenorrheaStepwise logistic regressionIpsilateral tubeLinear salpingostomyPostoperative surveillanceRepeat surgerySurgical approachComplete salpingectomySalpingostomyPregnancyConservative proceduresLogistic regressionParticular cautionPatientsEctopicWomenSalpingectomy