2022
Emerging Concepts: Role of Vitamin D Deficiency in the Pathogenesis of PCOS
Simpson S, Pal L, Seifer D. Emerging Concepts: Role of Vitamin D Deficiency in the Pathogenesis of PCOS. 2022, 489-509. DOI: 10.1007/978-3-030-92589-5_24.Peer-Reviewed Original ResearchPolycystic ovary syndromeVitamin D deficiencyD deficiencyVitamin DDiabetes mellitusCardiovascular diseaseInsulin resistanceContext of PCOSPathogenesis of PCOSType 2 diabetes mellitusParacrine/autocrine roleSpectrum of morbidityMultiple clinical studiesPoor reproductive outcomesAbnormal reproductive functionFeatures of depressionNonhuman primate studiesFemale reproductive tractImpaired folliculogenesisOvary syndromeEndometrial cancerCommon endocrinopathySkeletal healthClinical associationsLifetime risk
2020
8. Level of Anti-Müllerian Hormone and the Association of Vitamin D Deficiency with Polycystic Ovarian Syndrome in Adolescent Females
Simpson S, Seifer D, Shabanova V, Lynn A, Howe C, Rowe E, Caprio S, Vash-Margita A. 8. Level of Anti-Müllerian Hormone and the Association of Vitamin D Deficiency with Polycystic Ovarian Syndrome in Adolescent Females. Journal Of Pediatric And Adolescent Gynecology 2020, 33: 241-242. DOI: 10.1016/j.jpag.2020.01.067.Peer-Reviewed Original Research
2018
Vitamin D, early first trimester human chorionic gonadotropin kinetics, and birthweight: evidence of hormonal regulation of fetal growth in women with vitamin D deficiency
Senapati S, Butts S, Koelper N, Sammel M, Seifer D, Legro R, Diamond M. Vitamin D, early first trimester human chorionic gonadotropin kinetics, and birthweight: evidence of hormonal regulation of fetal growth in women with vitamin D deficiency. Fertility And Sterility 2018, 110: e49-e50. DOI: 10.1016/j.fertnstert.2018.07.155.Peer-Reviewed Original ResearchVitamin D Deficiency Is Associated With Poor Ovarian Stimulation Outcome in PCOS but Not Unexplained Infertility
Butts SF, Seifer DB, Koelper N, Senapati S, Sammel MD, Hoofnagle AN, Kelly A, Krawetz SA, Santoro N, Zhang H, Diamond MP, Legro RS, Network E. Vitamin D Deficiency Is Associated With Poor Ovarian Stimulation Outcome in PCOS but Not Unexplained Infertility. The Journal Of Clinical Endocrinology & Metabolism 2018, 104: 369-378. PMID: 30085176, PMCID: PMC6300410, DOI: 10.1210/jc.2018-00750.Peer-Reviewed Original ResearchConceptsVitamin D deficiencyPolycystic ovary syndromeD deficiencyEarly pregnancy lossOvarian stimulationUnexplained infertilityLive birthsPregnancy lossDiagnosis of PCOSMultiple Intrauterine GestationsOvarian stimulation outcomesRetrospective cohort studyInvestigation of womenBanked seraPPCOS IICohort studyIntrauterine gestationOvary syndromeInfertile womenInfertility diagnosisPregnant subjectsElevated riskImportant treatmentReproductive outcomesTrial data
2017
Vitamin D deficiency is associated with poor reproductive outcomes in PCOS but not unexplained infertility
Butts S, Seifer D, Senapati S, Koelper N, Legro R, Diamond M. Vitamin D deficiency is associated with poor reproductive outcomes in PCOS but not unexplained infertility. Fertility And Sterility 2017, 108: e69-e70. DOI: 10.1016/j.fertnstert.2017.07.220.Peer-Reviewed Original Research
2014
Vitamin D Normalizes Abnormally Elevated Serum Antimüllerian Hormone Levels Usually Noted in Women With Polycystic Ovary Syndrome
Irani M, Seifer D, Minkoff H, Merhi Z. Vitamin D Normalizes Abnormally Elevated Serum Antimüllerian Hormone Levels Usually Noted in Women With Polycystic Ovary Syndrome. Obstetrics And Gynecology 2014, 123: 189s. DOI: 10.1097/01.aog.0000447216.52829.8e.Peer-Reviewed Original ResearchPolycystic ovary syndromeVitamin D3 supplementationAntimüllerian hormone concentrationsVitamin D deficiencyD3 supplementationAntimüllerian hormoneD deficiencyHormone concentrationsControl groupVitamin D3 therapyHormone serum levelsNon-PCOS womenSerum of womenAntimüllerian hormone levelsWeeks of supplementationOvulatory dysfunctionD3 therapyDeficient womenOvary syndromeSerum levelsVitamin DMetabolic disturbancesHormone levelsVitamin D3Follicular healthVitamin D Increases Serum Levels of the Soluble Receptor for Advanced Glycation End Products in Women With PCOS
Irani M, Minkoff H, Seifer DB, Merhi Z. Vitamin D Increases Serum Levels of the Soluble Receptor for Advanced Glycation End Products in Women With PCOS. The Journal Of Clinical Endocrinology & Metabolism 2014, 99: e886-e890. PMID: 24606102, DOI: 10.1210/jc.2013-4374.Peer-Reviewed Original ResearchConceptsAdvanced glycation end productsPolycystic ovary syndromeAnti-Mullerian hormoneSerum anti-Mullerian hormoneGlycation end productsVitamin DSerum sRAGED3 supplementationDeficient womenAMH concentrationsVit D3Soluble receptorDeposition of AGEsAbnormal ovarian folliculogenesisDihydroxyvitamin D3 supplementationSerum sRAGE levelsVit D3 supplementationVitamin D supplementationSerum AMH levelsVitamin D deficiencyBody mass indexD supplementationAMH levelsD deficiencySRAGE levels
2013
Potential Mechanisms for Racial and Ethnic Differences in Antimüllerian Hormone and Ovarian Reserve
Tal R, Seifer DB. Potential Mechanisms for Racial and Ethnic Differences in Antimüllerian Hormone and Ovarian Reserve. International Journal Of Endocrinology 2013, 2013: 818912. PMID: 24348557, PMCID: PMC3857838, DOI: 10.1155/2013/818912.Peer-Reviewed Original ResearchOvarian reserveAntimüllerian hormoneRacial differencesSerum antimüllerian hormoneSerum AMH levelsVitamin D deficiencyReproductive technology treatmentEthnic differencesImportant clinical implicationsSuch racial differencesAMH levelsD deficiencyInfertility treatmentTreatment outcomesReproductive endocrinologistsReproductive planningEthnic groupsTimely interventionClinical implicationsReproductive agingSensitive biomarkerTechnology treatmentEthnic variationGenetic factorsPotential mechanisms