2025
The Molecular Basis of Polycystic Ovary Syndrome and Its Cardiometabolic Correlates: Exploring the Intersection and Its Clinical Implications—A Narrative Review
Mahabamunuge J, Sekula N, Lepore C, Kudrimoti M, Upadhyay A, Alshowaikh K, Li H, Seifer D, AlAshqar A. The Molecular Basis of Polycystic Ovary Syndrome and Its Cardiometabolic Correlates: Exploring the Intersection and Its Clinical Implications—A Narrative Review. Biomedicines 2025, 13: 709. PMID: 40149685, PMCID: PMC11940587, DOI: 10.3390/biomedicines13030709.Peer-Reviewed Original ResearchPolycystic ovary syndromeType 2 diabetes mellitusCardiometabolic morbidityIncreased cardiovascular riskDevelopment of hypertensionCardiovascular risk factorsNarrative reviewPotential clinical implicationsAndrogen excessEndothelial dysfunctionCardiovascular riskClinical conditionsPredisposed individualsTherapeutic strategiesAdipokine secretionRisk factorsInsulin resistanceCardiometabolic diseasesCardiovascular diseaseClinical implicationsMorbidityMellitusSyndromeMolecular mechanismsDisease
2022
Anti-Mullerian Hormone Signaling: Relevance for Pathophysiology of PCOS and Implications for Novel Therapeutic Approaches to Managing Ovulatory Dysfunction of PCOS
Shapiro A, Kushnir V, Seifer D. Anti-Mullerian Hormone Signaling: Relevance for Pathophysiology of PCOS and Implications for Novel Therapeutic Approaches to Managing Ovulatory Dysfunction of PCOS. 2022, 511-525. DOI: 10.1007/978-3-030-92589-5_25.Peer-Reviewed Original ResearchPolycystic ovary syndromeAnti-Mullerian hormonePathophysiology of PCOSSerum anti-Mullerian hormoneElevated AMH levelsAvailable treatment modalitiesNovel therapeutic approachesFuture therapeutic targetsChronic anovulationOvulatory dysfunctionAMH levelsOvary syndromeOvulatory functionTreatment modalitiesNormal folliculogenesisTherapeutic approachesTherapeutic targetPatientsCritical roleAnovulationDysfunctionPathophysiologySyndromeFolliculogenesisHormone
2020
8. Level of Anti-Müllerian Hormone and the Association of Vitamin D Deficiency with Polycystic Ovarian Syndrome in Adolescent Females
Simpson S, Seifer D, Shabanova V, Lynn A, Howe C, Rowe E, Caprio S, Vash-Margita A. 8. Level of Anti-Müllerian Hormone and the Association of Vitamin D Deficiency with Polycystic Ovarian Syndrome in Adolescent Females. Journal Of Pediatric And Adolescent Gynecology 2020, 33: 241-242. DOI: 10.1016/j.jpag.2020.01.067.Peer-Reviewed Original Research
2012
Preeclampsia-associated soluble endoglin (sENG) is decreased in polycystic ovarian syndrome (PCOS) leading to transforming growth factor (TGF)-B1 dysregulation during controlled ovarian stimulation
Tal R, Seifer D, Shohat-Tal A, Grazi R, Malter H. Preeclampsia-associated soluble endoglin (sENG) is decreased in polycystic ovarian syndrome (PCOS) leading to transforming growth factor (TGF)-B1 dysregulation during controlled ovarian stimulation. Fertility And Sterility 2012, 98: s84. DOI: 10.1016/j.fertnstert.2012.07.304.Peer-Reviewed Original Research
2007
Serum müllerian-inhibiting substance in Down's syndrome pregnancies
Seifer DB, MacLaughlin DT, Cuckle HS. Serum müllerian-inhibiting substance in Down's syndrome pregnancies. Human Reproduction 2007, 22: 1017-1020. PMID: 17218369, DOI: 10.1093/humrep/del497.Peer-Reviewed Original ResearchConceptsDown syndrome pregnanciesMüllerian-inhibiting substanceSyndrome pregnanciesUnaffected pregnanciesPregnancy-associated plasma proteinMI levelsMaternal serum levelsSerum MIS levelsWeeks of gestationCase-control studyAntenatal screening programmeAssisted reproduction techniquesMedian valueSerum levelsMIS levelsMaternal ageScreening programPregnancyDown syndromeUnaffected controlsReproduction techniquesSignificant correlationSyndromePlasma proteinsSerum
2005
Metformin reduces serum müllerian-inhibiting substance levels in women with polycystic ovary syndrome after protracted treatment
Fleming R, Harborne L, MacLaughlin DT, Ling D, Norman J, Sattar N, Seifer DB. Metformin reduces serum müllerian-inhibiting substance levels in women with polycystic ovary syndrome after protracted treatment. Fertility And Sterility 2005, 83: 130-136. PMID: 15652898, DOI: 10.1016/j.fertnstert.2004.05.098.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeDoses of metforminObese womenOvary syndromeMenstrual frequencyMetformin treatmentHormone changesReproductive hormone changesMonths of treatmentCohort of folliclesUniversity Teaching HospitalOvarian responseOvarian functionTeaching hospitalMAIN OUTCOMEMIS concentrationsProspective treatmentSubstance levelsMetforminMonthsWomenAssessment periodTreatmentSyndromeDoses
1985
Heparin-Induced Thrombocytopenia and Thrombosis: Detection and Specificity of a Platelet-Aggregating IgG
Sandler R, Seifer D, Morgan K, Pockros P, Wypych J, Weiss L, Schiffman S. Heparin-Induced Thrombocytopenia and Thrombosis: Detection and Specificity of a Platelet-Aggregating IgG. American Journal Of Clinical Pathology 1985, 83: 760-764. PMID: 4003343, DOI: 10.1093/ajcp/83.6.760.Peer-Reviewed Original ResearchConceptsMultiple arterial occlusionsResult of thrombocytopeniaHeparin-Induced ThrombocytopeniaSamples of serumPlatelet-aggregating factorCatastrophic syndromeWorst sequelaeAntithrombotic therapyHeparin therapyArterial occlusionArterial thrombosisIgG productionPresence of heparinNormal plateletsPlasma samplesHeparinThrombocytopeniaFurther studiesThrombosisTherapyIgGSequelaeSepticemiaSyndromeWater intoxication and hyponatremic encephalopathy from the use of an oxytocin nasal spray. A case report.
Seifer DB, Sandberg EC, Ueland K, Sladen RN. Water intoxication and hyponatremic encephalopathy from the use of an oxytocin nasal spray. A case report. The Journal Of Reproductive Medicine 1985, 30: 225-8. PMID: 3923190.Peer-Reviewed Original ResearchConceptsOxytocin nasal sprayNasal sprayWater intoxicationGuillain-Barré typeSevere water intoxicationGuillain-Barré syndromeHyponatremic encephalopathyPeripheral polyneuritisInappropriate secretionNeurologic manifestationsSame hospitalizationViral illnessBreast feedIntravenous fluidsCase reportNursing womenNursing mothersAntidiuretic hormoneUnmonitored useTemporal associationPatientsConvulsionsSyndromeWork daysIntoxication
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