2008
Variations in serum müllerian inhibiting substance between white, black, and Hispanic women
Seifer DB, Golub ET, Lambert-Messerlian G, Benning L, Anastos K, Watts DH, Cohen MH, Karim R, Young MA, Minkoff H, Greenblatt RM. Variations in serum müllerian inhibiting substance between white, black, and Hispanic women. Fertility And Sterility 2008, 92: 1674-1678. PMID: 18930217, PMCID: PMC3037722, DOI: 10.1016/j.fertnstert.2008.08.110.Peer-Reviewed Original ResearchConceptsBody mass indexHispanic womenHIV statusMass indexMulticenter prospective cohort studyWomen's Interagency HIV StudySerum MIS levelsProspective cohort studyTime pointsCohort studyDifferent time pointsMIS levelsAge-related declineHIV StudyDifferent time coursesMAIN OUTCOMESubstance levelsSerum MISWhite womenSerum samplesDifferent racial groupsWomenIndependent effectsLongitudinal studySmoking
2007
Biologic markers of ovarian reserve and reproductive aging: application in a cohort study of HIV infection in women
Seifer DB, Golub ET, Lambert-Messerlian G, Springer G, Holman S, Moxley M, Cejtin H, Nathwani N, Anastos K, Minkoff H, Greenblatt RM. Biologic markers of ovarian reserve and reproductive aging: application in a cohort study of HIV infection in women. Fertility And Sterility 2007, 88: 1645-1652. PMID: 17418155, PMCID: PMC2682326, DOI: 10.1016/j.fertnstert.2007.01.122.Peer-Reviewed Original ResearchConceptsWomen's Interagency HIV StudyEarly follicular phaseOvarian reserveInhibin BHIV infectionMIS levelsFollicular phaseHIV StudyLower inhibin B levelsReproductive agingSerum samplesHIV infection influencesInhibin B levelsMulticenter prospective studyCross-sectional studyMenstrual cycle phaseCycle phaseUninfected womenCohort studyFSH levelsMenstrual bleedingNegative womenHIV serostatusSerum markersProspective study
2004
Serum antimüllerian hormone/müllerian-inhibiting substance appears to be a more discriminatory marker of assisted reproductive technology outcome than follicle-stimulating hormone, inhibin B, or estradiol
Hazout A, Bouchard P, Seifer DB, Aussage P, Junca AM, Cohen-Bacrie P. Serum antimüllerian hormone/müllerian-inhibiting substance appears to be a more discriminatory marker of assisted reproductive technology outcome than follicle-stimulating hormone, inhibin B, or estradiol. Fertility And Sterility 2004, 82: 1323-1329. PMID: 15533354, DOI: 10.1016/j.fertnstert.2004.03.061.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnti-Mullerian HormoneBiomarkersEstradiolFemaleFertilization in VitroFollicle Stimulating HormoneGlycoproteinsHumansInhibinsMultivariate AnalysisOsmolar ConcentrationOvulation InductionPredictive Value of TestsPregnancyPregnancy RateRetrospective StudiesTesticular HormonesTime FactorsTreatment OutcomeConceptsReproductive technology outcomesMullerian-inhibiting substanceYears of ageMultivariate regression analysisInhibin BPregnancy outcomesIVF outcomesAntimullerian hormoneHigher clinical pregnancy rateSerum samplesAvailable serum markersDay 3 FSHSerum antimullerian hormoneClinical pregnancy rateClinical pregnancy outcomesInhibin B levelsFollicle-stimulating hormoneConsecutive serum samplesMüllerian-inhibiting substanceGreater prognostic valueTechnology outcomesRegression analysisClinical pregnancyOvarian stimulationOvulation induction
2002
Early follicular serum müllerian-inhibiting substance levels are associated with ovarian response during assisted reproductive technology cycles
Seifer DB, MacLaughlin DT, Christian BP, Feng B, Shelden RM. Early follicular serum müllerian-inhibiting substance levels are associated with ovarian response during assisted reproductive technology cycles. Fertility And Sterility 2002, 77: 468-471. PMID: 11872196, DOI: 10.1016/s0015-0282(01)03201-0.Peer-Reviewed Original ResearchConceptsOvarian responseMIS concentrationsReproductive technology cyclesGreater serum concentrationsGroup of womenOvulation inductionSerum concentrationsMaximum serumRetrospective analysisMAIN OUTCOMESubstance levelsSerum MISSerum samplesMI levelsWomenMature oocytesTechnology cyclesReproductive technologiesOocytesSerumART programsGroupIVFGreater number
2000
Progesterone, Inhibin, and hCG Multiple Marker Strategy to Differentiate Viable From Nonviable Pregnancies
PHIPPS M, HOGAN J, PEIPERT J, LAMBERT-MESSERLIAN G, CANICK J, SEIFER D. Progesterone, Inhibin, and hCG Multiple Marker Strategy to Differentiate Viable From Nonviable Pregnancies. Obstetrics And Gynecology 2000, 95: 227-231. DOI: 10.1097/00006250-200002000-00011.Peer-Reviewed Original ResearchMeSH KeywordsAdultBiomarkersChorionic GonadotropinChorionic Gonadotropin, beta Subunit, HumanCohort StudiesFemaleFetal ViabilityHumansInhibinsPredictive Value of TestsPregnancyPregnancy ComplicationsPregnancy OutcomePregnancy Trimester, FirstProgesteroneProspective StudiesROC CurveSensitivity and SpecificityConceptsDual-biomarker strategyMultiple biomarker strategyNonviable pregnanciesSerum progesteroneBiomarker strategiesComplaints of painProspective cohort studySymptomatic pregnant womenCombination of progesteroneCohort studyCombination of serumInhibin AUrine biomarkersFirst trimesterPregnant womenEarly gestationNonviable outcomesPregnancySingle biomarkerHCGProgesteroneSpecific biomarkersDiagnostic accuracySerum samplesBiomarkersProgesterone, inhibin, and hCG multiple marker strategy to differentiate viable from nonviable pregnancies.
Phipps M, Hogan J, Peipert J, Lambert-Messerlian G, Canick J, Seifer D. Progesterone, inhibin, and hCG multiple marker strategy to differentiate viable from nonviable pregnancies. Obstetrics And Gynecology 2000, 95: 227-31. PMID: 10674584, DOI: 10.1016/s0029-7844(99)00480-9.Peer-Reviewed Original ResearchMeSH KeywordsAdultBiomarkersChorionic GonadotropinChorionic Gonadotropin, beta Subunit, HumanCohort StudiesFemaleFetal ViabilityHumansInhibinsPredictive Value of TestsPregnancyPregnancy ComplicationsPregnancy OutcomePregnancy Trimester, FirstProgesteroneProspective StudiesROC CurveSensitivity and SpecificityConceptsDual-biomarker strategyMultiple biomarker strategyNonviable pregnanciesSerum progesteroneBiomarker strategiesComplaints of painProspective cohort studySymptomatic pregnant womenCombination of progesteroneCohort studyCombination of serumInhibin AUrine biomarkersFirst trimesterPregnant womenEarly gestationNonviable outcomesPregnancySingle biomarkerHCGProgesteroneSpecific biomarkersDiagnostic accuracySerum samplesBiomarkers
1996
Serum inhibin levels are lower in ectopic than intrauterine spontaneously conceived pregnancies*†*Presented in part at the 42nd Annual Meeting of the Society for Gynecological Investigation, Chicago, Illinois, March 15 to 18, 1995.†Supported in part by Physician Scientist Award from National Institutes of Health, National Institute on Aging grant AG00566 (D.B.S.) and HD29164 (G.M.L.M., A.L.S.).
Seifer D, Lambert-Messerlian G, Canick J, Frishman G, Schneyer A. Serum inhibin levels are lower in ectopic than intrauterine spontaneously conceived pregnancies*†*Presented in part at the 42nd Annual Meeting of the Society for Gynecological Investigation, Chicago, Illinois, March 15 to 18, 1995.†Supported in part by Physician Scientist Award from National Institutes of Health, National Institute on Aging grant AG00566 (D.B.S.) and HD29164 (G.M.L.M., A.L.S.). Fertility And Sterility 1996, 65: 667-669. PMID: 8774307, DOI: 10.1016/s0015-0282(16)58174-6.Peer-Reviewed Original ResearchConceptsIntrauterine pregnancySerum inhibin concentrationsDimeric inhibinInhibin concentrationsTotal inhibinMaternal serumSerum samplesDimeric inhibin concentrationSingle intrauterine pregnancySerum inhibin levelsCase-control studyAcademic clinical practiceNational InstituteAlpha-inhibin subunitGynecological InvestigationInhibin levelsSonographic evidenceGestational ageInhibin subunitsWeek 8MAIN OUTCOMEClinical practiceInhibinEctopicWomen
1994
Urine hCG beta-subunit core fragment, a sensitive test for ectopic pregnancy
Cole LA, Kardana A, Seifer DB, Bohler HC. Urine hCG beta-subunit core fragment, a sensitive test for ectopic pregnancy. The Journal Of Clinical Endocrinology & Metabolism 1994, 78: 497-499. PMID: 7508952, DOI: 10.1210/jcem.78.2.7508952.Peer-Reviewed Original ResearchConceptsTubal pregnancyBeta-core fragmentEmergency roomIntrauterine pregnancyEctopic pregnancyPregnancy levelsUrine samplesNormal levelsNormal intrauterine pregnancyPregnancy serum samplesMicrograms/LPregnancy concentrationsHCG levelsNormal pregnancyAdditional patientsBeta immunoreactivityHCG testPregnancy samplesPregnancyMedian levelsPredictive valueHCGSerum samplesGlycoprotein hormonesSensitive testDehydroepiandrosterone sulfate and anovulation increase serum inhibin and affect follicular function during administration of gonadotropins
Haning RV, Hua JJ, Hackett RJ, Wheeler CA, Frishman GN, Seifer DB, Dahl CA, Burger HG. Dehydroepiandrosterone sulfate and anovulation increase serum inhibin and affect follicular function during administration of gonadotropins. The Journal Of Clinical Endocrinology & Metabolism 1994, 78: 145-149. PMID: 8288697, DOI: 10.1210/jcem.78.1.8288697.Peer-Reviewed Original ResearchConceptsNumber of oocytesAnovulatory subjectsSerum inhibinAnovulatory ovariesSerum concentrationsNormal subjectsSerum DS concentrationSerum inhibin concentrationsAdministration of gonadotropinSecretion of inhibinResidual serum samplesDuration of treatmentAnovulatory patientsGonadotropin therapyInhibin concentrationsInhibin secretionPatient ageFertilization cyclesGonadotropin treatmentLH dosesFollicular functionHCG treatmentInhibinAverage durationSerum samples
1993
Selecting human chorionic gonadotropin immunoassays: Consideration of cross-reacting molecules in first-trimester pregnancy serum and urine
Cole L, Seifer D, Kardana A, Braunstein G. Selecting human chorionic gonadotropin immunoassays: Consideration of cross-reacting molecules in first-trimester pregnancy serum and urine. American Journal Of Obstetrics And Gynecology 1993, 168: 1580-1586. PMID: 8498446, DOI: 10.1016/s0002-9378(11)90802-3.Peer-Reviewed Original ResearchConceptsHuman chorionic gonadotropinTotal human chorionic gonadotropin levelHuman chorionic gonadotropin levelsTotal human chorionic gonadotropinChorionic gonadotropin levelsChorionic gonadotropinGonadotropin levelsPregnancy serumFirst trimester pregnancy seraHuman chorionic gonadotropin resultsNicked human chorionic gonadotropinHuman chorionic gonadotropin immunoassaysFree beta subunitGonadotropin resultsEarly pregnancyCross-reacting moleculesHome test kitsPregnancy testBeta assaysGonadotropinMedian levelsDiscordant resultsDifferent commercial kitsSerum samplesFree beta