2024
Assessment of a Decade of Change in U.S. Assisted Reproductive Technology Cumulative Live-Birth Rates
Wang S, Seifer D. Assessment of a Decade of Change in U.S. Assisted Reproductive Technology Cumulative Live-Birth Rates. Obstetrics And Gynecology 2024, 143: 839-848. PMID: 38696814, DOI: 10.1097/aog.0000000000005598.Peer-Reviewed Original ResearchConceptsCumulative live birth rateLive birth rateAssisted reproductive technologyPreimplantation genetic testingInfertility diagnosisLive birthsOvulatory disordersGenetic testingReproductive technologyOdds of live birthMale factor infertilityFrozen embryo transferDiminished ovarian reserveClinical practiceRetrospective cohort studyAssociated with decreased oddsSART CORS databaseField of assisted reproductive technologyDemographic shiftsSART CORSOvarian reserveInfertility causeEmbryo transferCounseling patientsCohort studyAge-related increase in live-birth rates of first frozen thaw embryo versus first fresh transfer in initial assisted reproductive technology cycles without PGT
Wang S, Seifer D. Age-related increase in live-birth rates of first frozen thaw embryo versus first fresh transfer in initial assisted reproductive technology cycles without PGT. Reproductive Biology And Endocrinology 2024, 22: 42. PMID: 38615016, PMCID: PMC11015537, DOI: 10.1186/s12958-024-01210-0.Peer-Reviewed Original ResearchConceptsFrozen-thawed embryo transferCumulative live birth rateLive birth rateDiminished ovarian reservePreimplantation genetic testingMultivariate logistic regressionFresh transferLive birth outcomesLive birthsEmbryo transferAssisted reproductive technologyART cyclesEndometrial receptivityBirth outcomesFrozen-thawed embryo transfer cyclesOdds of live birthAssisted reproductive technology cyclesChance of live birthFresh embryo transferFrozen-thawed cyclesFrozen-thawed embryosMale factor infertilityRetrospective cohort studyEmbryo transfer methodsAge groups
2023
Effect of state insurance mandates on racial/ethnic disparities in the utilization and outcomes of donor oocyte–assisted reproductive technologies
Liao C, Kotlyar A, Seifer D. Effect of state insurance mandates on racial/ethnic disparities in the utilization and outcomes of donor oocyte–assisted reproductive technologies. Fertility And Sterility 2023, 120: 111-122. PMID: 36871857, DOI: 10.1016/j.fertnstert.2023.02.037.Peer-Reviewed Original ResearchConceptsBody mass indexUterine factor infertilityBlack recipientsART cyclesHispanic recipientsWhite recipientsEthnic disparitiesState insurance mandatesFactor infertilityMass indexAsian recipientsOocyte recipientsDonor oocytesLive birthsAssisted Reproductive Technology Clinic Outcome Reporting SystemRetrospective cohort studyCumulative probabilityRecurrent pregnancy lossMultivariable Poisson regressionFrozen-thawed transfersReproductive technologiesHigher median agePreimplantation genetic testingNon-Hispanic whitesInsurance mandates
2020
Status of racial disparities between black and white women undergoing assisted reproductive technology in the US
Seifer D, Simsek B, Wantman E, Kotlyar A. Status of racial disparities between black and white women undergoing assisted reproductive technology in the US. Reproductive Biology And Endocrinology 2020, 18: 113. PMID: 33213467, PMCID: PMC7677830, DOI: 10.1186/s12958-020-00662-4.Peer-Reviewed Original ResearchConceptsCumulative live birth rateLive birth rateReproductive technology outcomesWhite non-Hispanic womenBody mass indexEtiology of infertilityNon-Hispanic womenMass indexBirth rateBlack womenWhite non-Hispanic patientsTechnology outcomesLogistic regressionWhite womenRetrospective cohort studyNon-Hispanic patientsIndependent prognostic factorIntra-cytoplasmic sperm injectionProportion of cyclesMultivariate logistic regressionMultiple logistic regressionReproductive technologiesNumber of embryosCycle cancellationOvarian reserveDo state insurance mandates alter ICSI utilization?
Zagadailov P, Seifer DB, Shan H, Zarek SM, Hsu AL. Do state insurance mandates alter ICSI utilization? Reproductive Biology And Endocrinology 2020, 18: 33. PMID: 32334609, PMCID: PMC7183130, DOI: 10.1186/s12958-020-00589-w.Peer-Reviewed Original ResearchConceptsIntracytoplasmic sperm injectionElective single embryo transferClinical pregnancyICSI usePreimplantation genetic testingESET rateState insurance mandatesTwin rateInsurance mandatesRetrospective cohort studyLive birth rateLower clinical pregnancyMale factor infertilitySingle embryo transferBirth rateTwin birth rateT-testICSI rateLower LBRStrength of associationCohort studyFactor infertilityART cyclesResultsFrom 2000ART coverageHigh serum Antimullerian hormone levels are associated with lower live birth rates in women with polycystic ovarian syndrome undergoing assisted reproductive technology
Tal R, Seifer CM, Khanimov M, Seifer DB, Tal O. High serum Antimullerian hormone levels are associated with lower live birth rates in women with polycystic ovarian syndrome undergoing assisted reproductive technology. Reproductive Biology And Endocrinology 2020, 18: 20. PMID: 32156287, PMCID: PMC7065318, DOI: 10.1186/s12958-020-00581-4.Peer-Reviewed Original ResearchConceptsLive birth rateLower live birth ratesHigh AMH groupAMH groupPCOS womenHigh AMHAMH concentrationsFirst fresh IVF/ICSI cycleBirth rateFresh IVF/ICSI cyclesGreater clinical pregnancy ratesSerum antimullerian hormone (AMH) levelsIVF/ICSI cyclesAntimullerian hormone levelsClinical pregnancy rateControlled ovarian stimulationRetrospective cohort studySerum AMH levelsPolycystic ovarian syndromeSerum AMH concentrationsLive birth outcomesNumber of embryosAMH levelsGonadotropin doseOvarian stimulation
2018
Vitamin D Deficiency Is Associated With Poor Ovarian Stimulation Outcome in PCOS but Not Unexplained Infertility
Butts SF, Seifer DB, Koelper N, Senapati S, Sammel MD, Hoofnagle AN, Kelly A, Krawetz SA, Santoro N, Zhang H, Diamond MP, Legro RS, Network E. Vitamin D Deficiency Is Associated With Poor Ovarian Stimulation Outcome in PCOS but Not Unexplained Infertility. The Journal Of Clinical Endocrinology & Metabolism 2018, 104: 369-378. PMID: 30085176, PMCID: PMC6300410, DOI: 10.1210/jc.2018-00750.Peer-Reviewed Original ResearchConceptsVitamin D deficiencyPolycystic ovary syndromeD deficiencyEarly pregnancy lossOvarian stimulationUnexplained infertilityLive birthsPregnancy lossDiagnosis of PCOSMultiple Intrauterine GestationsOvarian stimulation outcomesRetrospective cohort studyInvestigation of womenBanked seraPPCOS IICohort studyIntrauterine gestationOvary syndromeInfertile womenInfertility diagnosisPregnant subjectsElevated riskImportant treatmentReproductive outcomesTrial dataTemporal Differences in Utilization of Intracytoplasmic Sperm Injection Among U.S. Regions
Zagadailov P, Hsu A, Stern JE, Seifer DB. Temporal Differences in Utilization of Intracytoplasmic Sperm Injection Among U.S. Regions. Obstetrics And Gynecology 2018, 132: 310-320. PMID: 29995722, DOI: 10.1097/aog.0000000000002730.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge FactorsCohort StudiesFemaleFertilization in VitroHumansInfertility, FemaleInfertility, MaleLive BirthMalePregnancyPregnancy RateRetrospective StudiesSperm Injections, IntracytoplasmicTreatment OutcomeUnited StatesUnited States Dept. of Health and Human ServicesYoung AdultConceptsLive birth rateUse of ICSIICSI rateICSI utilizationBirth rateRetrospective cohort studyMale factor infertilityHuman Services (HHS) regionsIntracytoplasmic sperm injectionYears of agePreimplantation genetic testingMale factor diagnosisDepartment of HealthNondonor cyclesCohort studyFertilization cyclesFactor infertilityMale factorSperm injectionMedical indicationsMagnitude of increaseClinicGenetic testingDisease controlICSI
2014
Assisted hatching and intracytoplasmic sperm injection are not associated with improved outcomes in assisted reproduction cycles for diminished ovarian reserve: an analysis of cycles in the United States from 2004 to 2011
Butts SF, Owen C, Mainigi M, Senapati S, Seifer DB, Dokras A. Assisted hatching and intracytoplasmic sperm injection are not associated with improved outcomes in assisted reproduction cycles for diminished ovarian reserve: an analysis of cycles in the United States from 2004 to 2011. Fertility And Sterility 2014, 102: 1041-1047.e1. PMID: 25086790, PMCID: PMC4184996, DOI: 10.1016/j.fertnstert.2014.06.043.Peer-Reviewed Original ResearchMeSH KeywordsChi-Square DistributionEmbryo Culture TechniquesEmbryo TransferFemaleHumansInfertility, FemaleLive BirthLogistic ModelsOdds RatioOvarian ReservePregnancyPregnancy RatePrimary Ovarian InsufficiencyRegistriesRetrospective StudiesRisk FactorsSperm Injections, IntracytoplasmicTime FactorsTreatment OutcomeUnited StatesConceptsDiminished ovarian reserveIntracytoplasmic sperm injectionElevated FSHLive birthsOvarian reserveART cyclesSperm injectionAssisted Reproductive Technology Clinic Outcome Reporting System databaseClinical pregnancy rateRetrospective cohort studyLive birth rateReproductive technology outcomesAssisted reproduction cyclesCombination of ICSIReporting System databaseCohort studyPrimary diagnosisImproved outcomesPregnancy rateMAIN OUTCOMELower oddsDiminished oddsFSHOnly indicationTechnology outcomesCharacterization of women with elevated antimüllerian hormone levels (AMH): correlation of AMH with polycystic ovarian syndrome phenotypes and assisted reproductive technology outcomes
Tal R, Seifer DB, Khanimov M, Malter HE, Grazi RV, Leader B. Characterization of women with elevated antimüllerian hormone levels (AMH): correlation of AMH with polycystic ovarian syndrome phenotypes and assisted reproductive technology outcomes. American Journal Of Obstetrics And Gynecology 2014, 211: 59.e1-59.e8. PMID: 24593938, DOI: 10.1016/j.ajog.2014.02.026.Peer-Reviewed Original ResearchConceptsSerum antimüllerian hormone levelsAntimüllerian hormone levelsClinical pregnancy ratePopulation of womenAMH levelsPregnancy rateHormone levelsHigher clinical pregnancy rateElevated AMH levelsPresence of amenorrheaMultiple pregnancy rateOvarian hyperstimulation syndromeRetrospective cohort studyHigher AMH levelsPolycystic ovarian morphologyPolycystic ovarian syndromeSyndrome phenotypeReproductive technology outcomesHyperstimulation syndromePCOS severityClinical pregnancyOvarian stimulationTotal testosteroneCohort studyOvarian syndrome
2007
Disparity in assisted reproductive technologies outcomes in black women compared with white women
Seifer DB, Frazier LM, Grainger DA. Disparity in assisted reproductive technologies outcomes in black women compared with white women. Fertility And Sterility 2007, 90: 1701-1710. PMID: 17980873, DOI: 10.1016/j.fertnstert.2007.08.024.Peer-Reviewed Original ResearchMeSH KeywordsAbortion, SpontaneousAdultBlack or African AmericanFemaleHealth Knowledge, Attitudes, PracticeHealthcare DisparitiesHumansInfertilityLive BirthPatient Acceptance of Health CareRegistriesReproductive Techniques, AssistedRetrospective StudiesRisk FactorsTime FactorsTreatment OutcomeUnited StatesWhite PeopleConceptsLive birth rateIVF cyclesWhite womenAssisted Reproductive Technology member clinicsBlack womenMarried reproductive age womenCycles of IVFIndependent risk factorRetrospective cohort studyReproductive technology outcomesReproductive-age womenUterine factor infertilityRace/ethnicityCohort studyFactor infertilityBlack raceRisk factorsSpontaneous abortionRegistry dataLive birthsMAIN OUTCOMEEmbryo cyclesIVF recipientsMember clinicsWomen
1997
Follicular fluid vascular endothelial growth factor concentrations are elevated in women of advanced reproductive age undergoing ovulation induction
Friedman C, Danforth D, Herbosa-Encarnacion C, Arbogast L, Alak B, Seifer D. Follicular fluid vascular endothelial growth factor concentrations are elevated in women of advanced reproductive age undergoing ovulation induction. Fertility And Sterility 1997, 68: 607-612. PMID: 9341598, DOI: 10.1016/s0015-0282(97)00278-1.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgingCobaltCohort StudiesCorpus LuteumEndothelial Growth FactorsFemaleFollicular FluidGranulosa CellsHumansHypoxiaLymphokinesMaternal AgeMiddle AgedOsmolar ConcentrationOvulation InductionPregnancyPregnancy, High-RiskRetrospective StudiesTime FactorsVascular Endothelial Growth Factor AVascular Endothelial Growth FactorsConceptsAdvanced reproductive ageVascular endothelial growth factor/vascular permeability factorVascular permeability factorReproductive ageFollicular fluidFactor concentrationsPermeability factorFollicular fluid vascular endothelial growth factor concentrationsGranulosa cellsVascular endothelial growth factor concentrationsYoung womenRetrospective cohort studyReproductive-age womenUniversity Teaching HospitalPg/mLGrowth factor concentrationsCohort studyIVF-ETOvulation inductionHCG administrationAge womenCobalt chlorideTeaching hospitalMAIN OUTCOMEFollicular aspiration