2014
Assisted hatching and intracytoplasmic sperm injection are not associated with improved outcomes in assisted reproduction cycles for diminished ovarian reserve: an analysis of cycles in the United States from 2004 to 2011
Butts SF, Owen C, Mainigi M, Senapati S, Seifer DB, Dokras A. Assisted hatching and intracytoplasmic sperm injection are not associated with improved outcomes in assisted reproduction cycles for diminished ovarian reserve: an analysis of cycles in the United States from 2004 to 2011. Fertility And Sterility 2014, 102: 1041-1047.e1. PMID: 25086790, PMCID: PMC4184996, DOI: 10.1016/j.fertnstert.2014.06.043.Peer-Reviewed Original ResearchMeSH KeywordsChi-Square DistributionEmbryo Culture TechniquesEmbryo TransferFemaleHumansInfertility, FemaleLive BirthLogistic ModelsOdds RatioOvarian ReservePregnancyPregnancy RatePrimary Ovarian InsufficiencyRegistriesRetrospective StudiesRisk FactorsSperm Injections, IntracytoplasmicTime FactorsTreatment OutcomeUnited StatesConceptsDiminished ovarian reserveIntracytoplasmic sperm injectionElevated FSHLive birthsOvarian reserveART cyclesSperm injectionAssisted Reproductive Technology Clinic Outcome Reporting System databaseClinical pregnancy rateRetrospective cohort studyLive birth rateReproductive technology outcomesAssisted reproduction cyclesCombination of ICSIReporting System databaseCohort studyPrimary diagnosisImproved outcomesPregnancy rateMAIN OUTCOMELower oddsDiminished oddsFSHOnly indicationTechnology outcomes
2013
Why we may abandon basal follicle-stimulating hormone testing: a sea change in determining ovarian reserve using antimüllerian hormone
Toner JP, Seifer DB. Why we may abandon basal follicle-stimulating hormone testing: a sea change in determining ovarian reserve using antimüllerian hormone. Fertility And Sterility 2013, 99: 1825-1830. PMID: 23548941, DOI: 10.1016/j.fertnstert.2013.03.001.Peer-Reviewed Original Research
2012
Diagnosis and treatment of diminished ovarian reserve in assisted reproductive technology cycles of women up to age 40 years: the role of insurance mandates
Butts SF, Ratcliffe S, Dokras A, Seifer DB. Diagnosis and treatment of diminished ovarian reserve in assisted reproductive technology cycles of women up to age 40 years: the role of insurance mandates. Fertility And Sterility 2012, 99: 382-388.e7. PMID: 23102859, PMCID: PMC3561490, DOI: 10.1016/j.fertnstert.2012.09.026.Peer-Reviewed Original ResearchConceptsLive birth rateAge 40 yearsART cyclesART coverageElevated FSHOvarian reserveTreatment outcomesReproductive technology treatment outcomesSpecific infertility diagnosisState insurance coverageReproductive technology cyclesDiminished ovarian reserveProportion of cyclesCross-sectional studyBirth rateReporting System databaseInsurance mandatesMix of patientsProvider factorsInfertility diagnosisMAIN OUTCOMEFSHSignificant associationTreatment prognosisAdditional studies
2001
Contribution of diminished ovarian reserve to hypofertility associated with endometriosis.
Hock DL, Sharafi K, Dagostino L, Kemmann E, Seifer DB. Contribution of diminished ovarian reserve to hypofertility associated with endometriosis. The Journal Of Reproductive Medicine 2001, 46: 7-10. PMID: 11209637.Peer-Reviewed Original ResearchConceptsStage III/IV endometriosisStage I/II endometriosisOvarian reserveFSH levelsFertilization/embryo transferHigh E2 levelsStage of endometriosisDay 3 levelsMale factor infertilityCase-control studyAge-matched controlsFactor infertilityE2 levelsEndometriosisEmbryo transferTotal groupProgressive lossControl levelsWomenSignificant differencesE2FSHLevelsPatientsInfertility
2000
Do women with unexplained recurrent pregnancy loss have higher day 3 serum FSH and estradiol values?
Trout S, Seifer D. Do women with unexplained recurrent pregnancy loss have higher day 3 serum FSH and estradiol values? Fertility And Sterility 2000, 74: 335-337. PMID: 10927054, DOI: 10.1016/s0015-0282(00)00625-7.Peer-Reviewed Original ResearchConceptsDay 3 serum FSHRecurrent pregnancy lossUnexplained recurrent pregnancy lossCauses of RPLSerum FSHPregnancy lossControl groupOvarian reserveDay 3 FSHUnexplained habitual abortionDiminished ovarian reservePresence of infertilityHistory of infertilityRetrospective comparative analysisUnexplained groupRPL groupHabitual abortionMean ageMAIN OUTCOMEFSHGreater incidenceTest groupWomenPotential roleInfertility
1996
Apoptosis as a function of ovarian reserve in women undergoing in vitro fertilization*†
Seifer D, Gardiner A, Ferreira K, Peluso J. Apoptosis as a function of ovarian reserve in women undergoing in vitro fertilization*†. Fertility And Sterility 1996, 66: 593-598. PMID: 8816622, DOI: 10.1016/s0015-0282(16)58573-2.Peer-Reviewed Original ResearchConceptsDay 3 serum FSHFSH levelsOvarian reserveSerum FSHMIU/Granulosa cellsCell countDiminished ovarian reserveMIU/mLAcademic clinical practiceLuteinized granulosa cellsApoptotic granulosa cellsIVF-ETFollicular aspiratesPreovulatory folliclesClinical practiceFlow cytometryWomenMean numberApoptotic cellsFSHGreater percentageFolliclesCellsViable cells