2017
Vitamin D Decreases Serum VEGF Correlating with Clinical Improvement in Vitamin D-Deficient Women with PCOS: A Randomized Placebo-Controlled Trial
Irani M, Seifer DB, Grazi RV, Irani S, Rosenwaks Z, Tal R. Vitamin D Decreases Serum VEGF Correlating with Clinical Improvement in Vitamin D-Deficient Women with PCOS: A Randomized Placebo-Controlled Trial. Nutrients 2017, 9: 334. PMID: 28350328, PMCID: PMC5409673, DOI: 10.3390/nu9040334.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeVascular endothelial growth factorOvarian hyperstimulation syndromeSerum VEGF levelsVitamin DVEGF levelsVitD supplementationVitD treatmentSeverity of OHSSSerum vascular endothelial growth factorRandomized placebo-controlled trialFerriman-Gallwey hirsutism scoreBeneficial effectsCharacteristic clinical abnormalitiesPlacebo-controlled trialVitamin D levelsVitamin D supplementationMultiple clinical parametersSignificant decreaseEndothelial growth factorD supplementationHirsutism scoreHyperstimulation syndromeVitD groupRandomized Placebo
2015
Vitamin D Supplementation Decreases TGF-β1 Bioavailability in PCOS: A Randomized Placebo-Controlled Trial
Irani M, Seifer DB, Grazi RV, Julka N, Bhatt D, Kalgi B, Irani S, Tal O, Lambert-Messerlian G, Tal R. Vitamin D Supplementation Decreases TGF-β1 Bioavailability in PCOS: A Randomized Placebo-Controlled Trial. The Journal Of Clinical Endocrinology & Metabolism 2015, 100: 4307-4314. PMID: 26485217, DOI: 10.1210/jc.2015-2580.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAntigens, CDBiological AvailabilityCholecalciferolDehydroepiandrosterone SulfateEndoglinFemaleHumansInsulin ResistanceLipidsPolycystic Ovary SyndromeProspective StudiesReceptors, Cell SurfaceSocioeconomic FactorsTestosteroneTransforming Growth Factor beta1Vitamin DVitamin D DeficiencyVitaminsYoung AdultConceptsPolycystic ovary syndromeVD supplementationTGF-β1Clinical manifestationsClinical parametersAcademic-affiliated medical centerFerriman-Gallwey scoreOral vitamin D3Serum TGF-β1Soluble endoglin levelsPlacebo-controlled trialVitamin D supplementationTGF-β1 levelsNew treatment modalitiesD supplementationOral placeboRandomized PlaceboOvary syndromeVD levelsEndoglin levelsInsulin resistanceTreatment modalitiesMenstrual periodLipid profileVitamin D3
2014
Vitamin D Increases Serum Levels of the Soluble Receptor for Advanced Glycation End Products in Women With PCOS
Irani M, Minkoff H, Seifer DB, Merhi Z. Vitamin D Increases Serum Levels of the Soluble Receptor for Advanced Glycation End Products in Women With PCOS. The Journal Of Clinical Endocrinology & Metabolism 2014, 99: e886-e890. PMID: 24606102, DOI: 10.1210/jc.2013-4374.Peer-Reviewed Original ResearchConceptsAdvanced glycation end productsPolycystic ovary syndromeAnti-Mullerian hormoneSerum anti-Mullerian hormoneGlycation end productsVitamin DSerum sRAGED3 supplementationDeficient womenAMH concentrationsVit D3Soluble receptorDeposition of AGEsAbnormal ovarian folliculogenesisDihydroxyvitamin D3 supplementationSerum sRAGE levelsVit D3 supplementationVitamin D supplementationSerum AMH levelsVitamin D deficiencyBody mass indexD supplementationAMH levelsD deficiencySRAGE levels
2013
Vitamin D supplementation appears to normalize serum AMH levels in vitamin D deficient premenopausal women
Irani M, Seifer D, Minkoff H, Merhi Z. Vitamin D supplementation appears to normalize serum AMH levels in vitamin D deficient premenopausal women. Fertility And Sterility 2013, 100: s338. DOI: 10.1016/j.fertnstert.2013.07.892.Peer-Reviewed Original Research