Featured Publications
Closing the gap on racial disparities—Increasing race and ethnicity demographics reporting in the Society for Assisted Reproductive Technology Clinic Outcome Reporting System Registry
Seifer D, Richard-Davis G, Alvero R. Closing the gap on racial disparities—Increasing race and ethnicity demographics reporting in the Society for Assisted Reproductive Technology Clinic Outcome Reporting System Registry. Fertility And Sterility 2024, 122: 40-41. PMID: 38346548, DOI: 10.1016/j.fertnstert.2024.02.012.Peer-Reviewed Original ResearchCumulative live birth rates with autologous oocytes plateau with fewer number of cycles for each year of age > 42
Seifer D, Wang S, Frankfurter D. Cumulative live birth rates with autologous oocytes plateau with fewer number of cycles for each year of age > 42. Reproductive Biology And Endocrinology 2023, 21: 94. PMID: 37872609, PMCID: PMC10591412, DOI: 10.1186/s12958-023-01144-z.Peer-Reviewed Original ResearchConceptsCumulative live birth rateLive birth rateART cyclesBirth rateDesignRetrospective cohort studyPrior ART cyclesUse of ICSIEtiology of infertilityNumber of oocytesAge categoriesSART CORS databaseYears of ageTreatment cycle numberRace/ethnicityAutologous cyclesResultsBetween 2014Ovarian reserveCohort studyBlastocyst transferWomen 46Women 42Age 45Live birthsMAIN OUTCOMEPhysician expectationsState insurance mandates are necessary but not sufficient for closing the racial and ethnic disparity gap in assisted reproductive technology
Volovsky M, Seifer D. State insurance mandates are necessary but not sufficient for closing the racial and ethnic disparity gap in assisted reproductive technology. Fertility And Sterility 2023, 121: 46-47. PMID: 37816429, DOI: 10.1016/j.fertnstert.2023.10.003.Peer-Reviewed Original ResearchASSESSMENT OF A DECADE OF CHANGE IN UNITED STATES ASSISTED REPRODUCTIVE TECHNOLOGY (ART) CUMULATIVE LIVE BIRTH RATES (CLBR): COMPARISON OF 2014-2020 VERSUS 2004-2009
Wang S, Seifer D. ASSESSMENT OF A DECADE OF CHANGE IN UNITED STATES ASSISTED REPRODUCTIVE TECHNOLOGY (ART) CUMULATIVE LIVE BIRTH RATES (CLBR): COMPARISON OF 2014-2020 VERSUS 2004-2009. Fertility And Sterility 2023, 120: e233-e234. DOI: 10.1016/j.fertnstert.2023.08.662.Peer-Reviewed Original ResearchCUMULATIVE LIVE BIRTH RATES WITH AUTOLOGOUS OOCYTES PLATEAU WITH FEWER NUMBER OF CYCLES FOR EACH YEAR ADVANCING BEYOND AGE 42: ANALYSIS OF 2014-2020 SARTCORS DATABASE
Wang S, Frankfurter D, Seifer D. CUMULATIVE LIVE BIRTH RATES WITH AUTOLOGOUS OOCYTES PLATEAU WITH FEWER NUMBER OF CYCLES FOR EACH YEAR ADVANCING BEYOND AGE 42: ANALYSIS OF 2014-2020 SARTCORS DATABASE. Fertility And Sterility 2023, 120: e99-e100. DOI: 10.1016/j.fertnstert.2023.08.277.Peer-Reviewed Original ResearchANALYSIS OF DEMOGRAPHIC CHANGE ON UNITED STATES (US) ASSISTED REPRODUCTIVE TECHNOLOGY (ART) LIVE BIRTH OUTCOMES: COMPARISON OF 2014-2020 VERSUS 2004-2009
Wang S, Seifer D. ANALYSIS OF DEMOGRAPHIC CHANGE ON UNITED STATES (US) ASSISTED REPRODUCTIVE TECHNOLOGY (ART) LIVE BIRTH OUTCOMES: COMPARISON OF 2014-2020 VERSUS 2004-2009. Fertility And Sterility 2023, 120: e233. DOI: 10.1016/j.fertnstert.2023.08.661.Peer-Reviewed Original ResearchWomen with PCOS who undergo IVF: a comprehensive review of therapeutic strategies for successful outcomes
Kotlyar A, Seifer D. Women with PCOS who undergo IVF: a comprehensive review of therapeutic strategies for successful outcomes. Reproductive Biology And Endocrinology 2023, 21: 70. PMID: 37528417, PMCID: PMC10391774, DOI: 10.1186/s12958-023-01120-7.Peer-Reviewed Original ResearchConceptsPolycystic ovarian syndromeOvarian hyperstimulation syndromeOvarian stimulationStimulation protocolFrozen embryo transfer cyclesVitamin D repletionGnRH agonist triggerVitamin D levelsEmbryo transfer cyclesOvarian stimulation protocolsAntagonist cyclesHyperstimulation syndromeHypertensive disordersIVF cyclesPCOS patientsAgonist triggerOvarian syndromeOocyte yieldD levelsImproved outcomesPregnancy rateCommon causeIVF performanceTherapeutic courseInfertile couplesRacial and Ethnic Disparities in Access to and Outcomes of Infertility Treatment and Assisted Reproductive Technology in the United States
Beroukhim G, Seifer D. Racial and Ethnic Disparities in Access to and Outcomes of Infertility Treatment and Assisted Reproductive Technology in the United States. Endocrinology And Metabolism Clinics Of North America 2023, 52: 659-675. PMID: 37865480, DOI: 10.1016/j.ecl.2023.05.005.Peer-Reviewed Original ResearchMeSH KeywordsAmerican Indian or Alaska NativeAsianBlack or African AmericanEthnicityFemaleHealth Services AccessibilityHealthcare DisparitiesHispanic or LatinoHumansInfertilityInfertility, FemalePregnancyPregnancy OutcomeReproductive Techniques, AssistedSocial Determinants of HealthUnited StatesWhiteConceptsEthnic disparitiesInfertility treatmentIntrauterine insemination pregnancy ratesHigh infertility rateAmerican Indian womenAssisted Reproductive TechnologyClinical pregnancyObstetrical complicationsFertility carePregnancy lossFavorable outcomePregnancy rateInfertility rateLive birthsHigher oddsART outcomesHispanic womenWhite womenRobust studiesWomenIndian womenReproductive technologiesBlack womenOutcomesCareOocyte Cryopreservation for Medical and Planned Indications: A Practical Guide and Overview
Han E, Seifer D. Oocyte Cryopreservation for Medical and Planned Indications: A Practical Guide and Overview. Journal Of Clinical Medicine 2023, 12: 3542. PMID: 37240648, PMCID: PMC10218997, DOI: 10.3390/jcm12103542.Peer-Reviewed Original ResearchOocyte cryopreservationAge-related fertility declineOvarian follicular lossFirst successful pregnancyElective oocyte cryopreservationFollicular lossGonadotoxic therapySuccessful pregnancyTreatment of cancerBiologic childrenFollicular fluidOvarian folliclesNarrative reviewMature oocytesOocytesPregnancyPatientsTherapyCancerFolliclesIn Vitro Gametogenesis in Oncofertility: A Review of Its Potential Use and Present-Day Challenges in Moving toward Fertility Preservation and Restoration
Wesevich V, Arkfeld C, Seifer D. In Vitro Gametogenesis in Oncofertility: A Review of Its Potential Use and Present-Day Challenges in Moving toward Fertility Preservation and Restoration. Journal Of Clinical Medicine 2023, 12: 3305. PMID: 37176745, PMCID: PMC10179531, DOI: 10.3390/jcm12093305.Peer-Reviewed Original ResearchPluripotent stem cellsPrimordial germ cell-like cellsGerm cell-like cellsStem cell biology researchStem cellsCell biology researchCell-like cellsVitro gametogenesisBiology researchReproductive lifespanGametogenesisFibroblast cellsDermal fibroblast cellsCellsReprogrammingEmbryogenesisOogoniaEmbryosViable oocytesFertilityReproductionSpermatocytesCurrent fertility preservation optionsOocytesEx vivo
2024
Elevated AMH is Useful in Making the Diagnosis of PCOM and Likely One Day the Diagnosis of PCOS
Seifer D. Elevated AMH is Useful in Making the Diagnosis of PCOM and Likely One Day the Diagnosis of PCOS. Fertility And Sterility 2024 PMID: 38977119, DOI: 10.1016/j.fertnstert.2024.07.002.Peer-Reviewed Original ResearchCurrent Status of Ovarian and Endometrial Biomarkers in Predicting ART Outcomes
Volovsky M, Seifer D. Current Status of Ovarian and Endometrial Biomarkers in Predicting ART Outcomes. Journal Of Clinical Medicine 2024, 13: 3739. PMID: 38999305, PMCID: PMC11242103, DOI: 10.3390/jcm13133739.Peer-Reviewed Original ResearchAssisted reproductive technologyGrowth differentiation factor 9Follicle-stimulating hormoneEndometrial biomarkersAnti-Mullerian hormoneBone morphogenetic protein 15Differentiation factor 9Immune markersOvarian biomarkersART outcomesGene profilesReproductive technologyFactor 9Predicting outcomeBiomarkersCustomized implantsProteomic technologiesHormoneOutcomesClinical integrationAssessment of a Decade of Change in U.S. Assisted Reproductive Technology Cumulative Live-Birth Rates
Wang S, Seifer D. Assessment of a Decade of Change in U.S. Assisted Reproductive Technology Cumulative Live-Birth Rates. Obstetrics And Gynecology 2024, 143: 839-848. PMID: 38696814, DOI: 10.1097/aog.0000000000005598.Peer-Reviewed Original ResearchConceptsCumulative live birth rateLive birth rateAssisted reproductive technologyPreimplantation genetic testingInfertility diagnosisLive birthsOvulatory disordersGenetic testingReproductive technologyOdds of live birthMale factor infertilityFrozen embryo transferDiminished ovarian reserveClinical practiceRetrospective cohort studyAssociated with decreased oddsSART CORS databaseField of assisted reproductive technologyDemographic shiftsSART CORSOvarian reserveInfertility causeEmbryo transferCounseling patientsCohort studyAge-related increase in live-birth rates of first frozen thaw embryo versus first fresh transfer in initial assisted reproductive technology cycles without PGT
Wang S, Seifer D. Age-related increase in live-birth rates of first frozen thaw embryo versus first fresh transfer in initial assisted reproductive technology cycles without PGT. Reproductive Biology And Endocrinology 2024, 22: 42. PMID: 38615016, PMCID: PMC11015537, DOI: 10.1186/s12958-024-01210-0.Peer-Reviewed Original ResearchConceptsFrozen-thawed embryo transferCumulative live birth rateLive birth rateDiminished ovarian reservePreimplantation genetic testingMultivariate logistic regressionFresh transferLive birth outcomesLive birthsEmbryo transferAssisted reproductive technologyART cyclesEndometrial receptivityBirth outcomesFrozen-thawed embryo transfer cyclesOdds of live birthAssisted reproductive technology cyclesChance of live birthFresh embryo transferFrozen-thawed cyclesFrozen-thawed embryosMale factor infertilityRetrospective cohort studyEmbryo transfer methodsAge groupsMoving toward Narrowing the United States Gap in Assisted Reproductive Technology (ART) Racial and Ethnic Disparities in the Next Decade
Mahabamunuge J, Seifer D. Moving toward Narrowing the United States Gap in Assisted Reproductive Technology (ART) Racial and Ethnic Disparities in the Next Decade. Journal Of Clinical Medicine 2024, 13: 2224. PMID: 38673497, PMCID: PMC11050514, DOI: 10.3390/jcm13082224.Peer-Reviewed Original ResearchA modern-day litmus test for the sustainability of daily IVF practice - Alabama supreme court ruling overreaches in asserting that frozen embryos are legally children
Seifer D. A modern-day litmus test for the sustainability of daily IVF practice - Alabama supreme court ruling overreaches in asserting that frozen embryos are legally children. Reproductive Biology And Endocrinology 2024, 22: 33. PMID: 38509519, PMCID: PMC10956278, DOI: 10.1186/s12958-024-01201-1.Peer-Reviewed Original Research
2023
AMH predicts miscarriage in non-PCOS but not in PCOS related infertility ART cycles
Arkfeld C, Han E, Tal R, Seifer D. AMH predicts miscarriage in non-PCOS but not in PCOS related infertility ART cycles. Reproductive Biology And Endocrinology 2023, 21: 35. PMID: 37020210, PMCID: PMC10074664, DOI: 10.1186/s12958-023-01087-5.Peer-Reviewed Original ResearchConceptsBody mass indexMiscarriage rateMean AMHART cyclesNumber of embryosElevated AMHAMH valuesOdds ratioNon-PCOS patientsOverall miscarriage rateConfidence intervalsAutologous embryo transferSART CORS databaseMultivariate regression analysisHeterotopic pregnancyClinical pregnancyAMH levelsIVF cyclesPCOS patientsPCOS populationIndependent predictorsMass indexPatient populationOocyte bankingAutologous transferEffect of state insurance mandates on racial/ethnic disparities in the utilization and outcomes of donor oocyte–assisted reproductive technologies
Liao C, Kotlyar A, Seifer D. Effect of state insurance mandates on racial/ethnic disparities in the utilization and outcomes of donor oocyte–assisted reproductive technologies. Fertility And Sterility 2023, 120: 111-122. PMID: 36871857, DOI: 10.1016/j.fertnstert.2023.02.037.Peer-Reviewed Original ResearchConceptsBody mass indexUterine factor infertilityBlack recipientsART cyclesHispanic recipientsWhite recipientsEthnic disparitiesState insurance mandatesFactor infertilityMass indexAsian recipientsOocyte recipientsDonor oocytesLive birthsAssisted Reproductive Technology Clinic Outcome Reporting SystemRetrospective cohort studyCumulative probabilityRecurrent pregnancy lossMultivariable Poisson regressionFrozen-thawed transfersReproductive technologiesHigher median agePreimplantation genetic testingNon-Hispanic whitesInsurance mandatesAMH independently predicts aneuploidy but not live birth per transfer in IVF PGT-A cycles
Li H, Seifer D, Tal R. AMH independently predicts aneuploidy but not live birth per transfer in IVF PGT-A cycles. Reproductive Biology And Endocrinology 2023, 21: 19. PMID: 36739415, PMCID: PMC9898926, DOI: 10.1186/s12958-023-01066-w.Peer-Reviewed Original ResearchConceptsAnti-Müllerian hormoneNumber of embryosEuploid embryosLive birthsOocyte qualityAge groupsSignificant independent predictorsCase-control analysisSART CORS databasePreimplantation genetic testingAMH levelsIVF cyclesIndependent predictorsIVF outcomesOocyte yieldNormal embryosPredictive roleGenetic testingFinal analysisBirthAgeIVFSubset of cyclesHormonePGT
2022
Evaluation of the Association of Endometrial Thickness, Insulin Resistance, and Menstrual Patterns in Adolescent Females with Polycystic Ovarian Syndrome
Lynn A, Solomon N, Zamani M, Rowe E, Seifer D, Vash-Margita A. Evaluation of the Association of Endometrial Thickness, Insulin Resistance, and Menstrual Patterns in Adolescent Females with Polycystic Ovarian Syndrome. Journal Of Pediatric And Adolescent Gynecology 2022, 36: 134-139. PMID: 36403727, DOI: 10.1016/j.jpag.2022.11.005.Peer-Reviewed Original ResearchConceptsPCOS groupInsulin resistanceMenstrual patternAdolescent femalesControl groupRetrospective case-control studyLarge-scale prospective studiesAcute pelvic painEndometrial stripe thicknessTransabdominal pelvic ultrasoundTertiary children's hospitalPolycystic ovarian syndromeBody mass indexCase-control studyInstitutional review boardAdolescent PCOSEndometrial thicknessPelvic painOvarian syndromePCOS diagnosisPelvic ultrasoundUnique pathophysiologyEndocrinology clinicChildren's HospitalMass index