WHRY Funds Studies on Stroke, Endometrial Cancer, and Addiction to Opioids
Women’s Health Research at Yale today announced funding for three studies investigating sex differences in stroke, endometrial cancer, and alternate pain relief for women recovering from past opioid use who are giving birth via cesarean section.
Spatial and Single Cell Characterization of Breast Cancer Progression: Presenter Profile
Presentation is about methods for assessment of multiple molecular variables on a single piece of tissue to better understand breast cancer (or really any cancer) with respect to progression or response or resistance to specific therapies.Source: SABCS Meeting News
Trastuzumab Deruxtecan Generates OS Benefit Vs Capecitabine-based Regimens in Pretreated HER2+ Breast Cancer
Trastuzumab deruxtecan demonstrated a 34% reduction in the risk of death and a 13-month increase in overall survival compared with treatment of physician’s choice in patients with advanced HER2-positive unresectable and/or metastatic breast cancer who received prior treatment with trastuzumab emtansine.Source: OncLive
Panel to Examine the Ongoing Evolution of Antibody Drug Conjugates in the Treatment of Breast Cancer
Antibody drug conjugates (ADCs), which use a targeted monoclonal antibody to deliver a cytotoxic payload, are among the most effective breast cancer therapies yet developed. The first Food and Drug Administration approval of an ADC in breast cancer, ado-trastuzumab emtansine, better known as T-DM1, sparked development of numerous new and promising ADCs for breast cancer.Source: SABCS Meeting News
Kirstie Alley and Colon Cancer: The Early Signs You Shouldn't Ignore
Actor Kirstie Alley has died after being diagnosed with colon cancer earlier this year. Colon cancer, also known as colorectal cancer, is the third most common type of cancer in the United States and globally. In the U.S. over 151,000 people will develop the disease in 2022.Source: Healthline
Berzosertib Plus Standard Chemoradiation Elicits Promising Responses in Locally Advanced HNSCC
Aarti Bhatia, MD, discusses the rationale for investigating berzosertib in this patient population, key updates from the phase 1 trial, and how these findings support the need for continued research of novel regimens in HNSCC.Source: OncLive
Career Path: Women in Leadership at High Levels
Reaching high-level leadership positions in medicine—and specifically oncology—is not an easy task and requires significant time and dedication. For women, there are a host of additional challenges to contend with as they navigate their career.Source: Oncology Times
Role of Nutrient May Reveal Dietary Target in Fight Against Microbial Infections
A nutrient that is common in the human diet has been found to aid the survival of a cancer-causing bacterium, a new Yale study finds. The findings could reveal an important target for new drugs to tackle numerous infectious diseases in humans.Source: Yale West Campus
Smilow Cancer Hospital and Yale Police Team to Raise Breast Cancer Awareness
Members of Smilow Cancer Hospital and Yale Cancer Center spent time together on Friday, October 28 on the New Haven Green with members of the Yale Police Department – along with a special, pink-themed Yale Police SUV – to highlight Breast Cancer Awareness Month.
New Findings on Endometrial Cancer Treated With Pembrolizumab
New research from Yale Cancer Center reveals for the first time ever a differential clinical response to pembrolizumab in Lynch-like (mutated) vs methylated microsatellite instability-high (MSI-H) uterine cancer patients, increasing our understanding about the proportion of patients that derive benefit from immune checkpoint blockade.
Scientists researching new scientific approach to identify cancer origins
Previous studies have shown the connection between age, exposure to carcinogens and the risk of developing cancer due to the accumulation of mutations over time. Scientists from Yale University and Emmanuel College demonstrate a new scientific approach to determine the origins of different types of cancer. Jeffrey Townsend, YSPH Elihu Professor of Biostatistics and Ecology & Evolutionary Biology, was a co-author of the study.Source: The Daily Campus
Dhanpat Jain, MD, Joins Pathologists Nationwide in Calling for Continued Use of Remote Work in Clinical Laboratories and Pathology
A group of pathologists and laboratory leaders from across the U.S. is urging federal officials to continue certain regulatory exemptions implemented during the COVID-19 pandemic that allow the use of remote work in clinical laboratories and pathology.
Juan Vasquez, MD, Vidya Puthenpura, MD, MHS, FAAP, Awarded Grants to Further Pediatric Cancer Research
Two rising young stars of pediatric cancer research at Yale Cancer Center and Yale School of Medicine were awarded research grants from Hyundai Hope on Wheels program to further their work of improving outcomes and treatment for children diagnosed with cancer.
Pamela Kunz, MD on 1999 Simone’s Maxims
Pamela Kunz, MD, associate professor (medical oncology) and vice chief of Diversity, Equity, and Inclusion (medical oncology) writes that, “I distinctly remember being told by mentors to read the original 1999 Simone’s Maxims – as these maxims were put on a pedestal as the truths of how to navigate academic medicine.”
Fighting Breast and Ovarian Cancer With a Lupus Antibody
After discovering a specific lupus antibody that can penetrate cancer cells and, with a grant from Women's Health Research at Yale, showing it makes cancer cells vulnerable to standard treatments, Dr. Peter Glazer and his colleagues are moving a treatment to clinical trials.
Sex Differences in Gastrointestinal Cancer
With this year's Wendy U. and Thomas C. Naratil Pioneer Award and co-funding from the Yale Cancer Center, Dr. Pamela Kunz is conducting one of the first studies to examine sex differences in treating neuroendocrine neoplasms (NENs), a rare form of cancer often found in the gastrointestinal tract.