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Pregnancy


Dr. Abrahams' lab studies Reproductive Immunology with a focus on the impact the immune system and immunological processes have on pregnancy outcome. Her research is concentrated on three main areas: 

1. Innate immune responses to infection at the maternal-fetal interface 
2. Mechanisms of antiphospholipid antibody-induced pregnancy complications
3. The role of placental microparticles in the pathogenesis of preeclampsia
Research in Dr. Guller’s laboratory focuses on placental dysfunction in adverse preterm pregnancy outcomes including preeclampsia (PE), intrauterine growth restriction, and chorioamnionitis (CAM). The overall goal of his work is to elucidate the role of major cell types of the placental villus, including syncytiotrophoblast, Hofbauer cells (HBCs, fetal macrophages), fibroblasts, and fetal endothelial cells, in mediating responses to glucocorticoid, hypoxia-reperfusion injury, and intrauterine infection.

Dr. Mak has three main areas of research interest:

  1. Understanding the role of a translational regulator, Pumilio, in the acquisition of the primordial follicle pool, oocyte maturation and maternal-to-zygotic transition. These studies will elucidate the genes important in establishing the ovarian reserve in women and identify new biomarkers of oocyte and embryo quality. 
Dr. Silasi is a Maternal-Fetal Medicine physician in the Section of Maternal-Fetal Medicine. Her research interests lie in the role of the immune system in complications of pregnancy, specifically preterm labor and preterm delivery. She currently is a WRHR scholar and is part of the Reproductive Immunology Unit.
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