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Dr. Leranth's Lab

Research Interests

Our laboratory is involved in a broad array of studies concerning the actions of gonadal hormones and the xenoestrogen, bisphenol A on the central nervous system of both rodents and subhuman primates. Data accumulated from animal experiments and clinical studies demonstrate that gonadal hormones have many effects on the nervous system that extend beyond regulating gonadotropin and prolactin secretion and modulating sexual behavior. Among these are the effects that gonadal hormones have on mnemonic functions and protecting neurons. 

Our primary interest is the indirect synaptoplastic effect of both estrogen and testosterone on brain areas associated with cognitive functions, including the hippocampus, prefrontal cortex and the ventral mesencephalic dopamine system. The other major field of our interest is to determine the way via bisphenol A exerts its negative effects on cognitive and social behaviors. In addition to these studies, this laboratory is also involved in investigating the morphological alterations in the prefrontal cortex of a non-human primate model of dopamine deficit and schizophrenia, determine the role of septal pathways in the regulation of hippocampal function by stress and antidepressant treatments, the effectiveness of growth factors produced by fetal striatal or kidney tissue, a specific striatal cell type, or the growth factor, GDNF, delivered biologically from encapsulated cells on the survival and integration of grafted, fetal dopamine cells into the striatum of a primate model of Parkinson’s disease. 

The main collaborators in these projects are Drs. Roth’s, Redmond’s and Elsworth’s laboratories.

Lab Members


Publications