Dr. Flannery's Lab

Research Interests

Dr. Flannery is interested in the effect of insulin resistance and obesity on endometrial pathology. Insulin resistance is also an underlying problem in the Polycystic Ovary Syndrome and Type 2 diabetes mellitus. Women with these conditions have a higher risk of irregular bleeding, implantation failure, miscarriage, endometrial hyperplasia, and endometrial carcinoma. The goal of Dr. Flannery’s research program is to determine whether this endometrial dysfunction is a consequence of the metabolic abnormalities occurring in insulin resistance. Using techniques in molecular biology, the Flannery lab examines potential mechanisms for how insulin contributes to the development of endometrial cancer. In addition, the Flannery lab is also investigating the role of insulin in normal placental function, as well as placental dysfunction in women with obesity.

Lab Members

Bio Profile

Clare Flannery, MD

Principal Investigator

Associate Professor Term

Co-Director, Yale University Reproductive Sciences Biobank (YURS)

Research Interests

Adenocarcinoma; Diabetes Mellitus; Endometrial Hyperplasia; Obesity

View Full Profile

Bio Profile

Katherine Cooke

Postgraduate Associate

View Full Profile

Bio Profile

Farrah Saleh

Senior Undergraduate Student

View Full Profile

Bio Profile

Aya Tal

Associate Research Scientist

View Full Profile

Bio Profile

Emily Xiao

Postgraduate Associate

View Full Profile


Flannery CA, Choe GH, Cooke KM, Fleming AG, Radford CC, Kodaman PH, Jurczak MJ, Kibbey RG, Taylor HS: Insulin Regulates Glycogen Synthesis in Human Endometrial Glands Through Increased GYS2. J Clin Endocrinol Metab. 2018 Aug 1. PMID: 29726999

Araque KA, Kadayakkara DK, Gigauri N, Sheehan D, Majumdar S, Buller G, Flannery CA: Reducing severe hypoglycaemia in hospitalised patients with diabetes: Early outcomes of standardised reporting and management. BMJ Open Qual. 2018; 2018 May 5. PMID: 29756070

Rackow BW, Vanden Brink H, Hammers L, Flannery CA, Lujan ME, Burgert TS: Ovarian Morphology by Transabdominal Ultrasound Correlates With Reproductive and Metabolic Disturbance in Adolescents With PCOS. J Adolesc Health. 2018 Mar; 2017 Dec 6. PMID: 29217212

Martin NM, Cooke KM, Radford CC, Perley LE, Silasi M, Flannery CA: Time course analysis of RNA quality in placenta preserved by RNAlater or flash freezing. Am J Reprod Immunol. 2017 Apr; 2017 Jan 31. PMID: 28138995

Flannery CA, Fleming AG, Choe GH, Naqvi H, Zhang M, Sharma A, Taylor HS: Endometrial Cancer-Associated FGF18 Expression Is Reduced by Bazedoxifene in Human Endometrial Stromal Cells In Vitro and in Murine Endometrium. Endocrinology. 2016 Oct; 2016 Jun 6. PMID: 27267714

Flannery CA, Saleh FL, Choe GH, Selen DJ, Kodaman PH, Kliman HJ, Wood TL, Taylor HS: Differential Expression of IR-A, IR-B and IGF-1R in Endometrial Physiology and Distinct Signature in Adenocarcinoma. J Clin Endocrinol Metab. 2016 Jul; 2016 Apr 18. PMID: 27088794

Flannery CA, Rowzee AM, Choe GH, Saleh FL, Radford CC, Taylor HS, Wood TL: Development of a Quantitative PCR Assay for Detection of Human Insulin-Like Growth Factor Receptor and Insulin Receptor Isoforms. Endocrinology. 2016 Apr; 2016 Feb 10. PMID: 26862994

Ghazal S, McKinnon B, Zhou J, Mueller M, Men Y, Yang L, Mueller M, Flannery C, Huang Y, Taylor HS: H19 lncRNA alters stromal cell growth via IGF signaling in the endometrium of women with endometriosis. EMBO Mol Med. 2015 Aug. PMID: 26089099

Han CS, Herrin MA, Pitruzzello MC, Mulla MJ, Werner EF, Pettker CM, Flannery CA, Abrahams VM: Glucose and metformin modulate human first trimester trophoblast function: a model and potential therapy for diabetes-associated uteroplacental insufficiency. Am J Reprod Immunol. 2015 Apr; 2014 Nov 14. PMID: 25394884

Gao Y, Wu F, Zhou J, Yan L, Jurczak MJ, Lee HY, Yang L, Mueller M, Zhou XB, Dandolo L, Szendroedi J, Roden M, Flannery C, Taylor H, Carmichael GG, Shulman GI, Huang Y: The H19/let-7 double-negative feedback loop contributes to glucose metabolism in muscle cells. Nucleic Acids Res. 2014 Dec 16; 2014 Nov 15. PMID: 25399420

Karalok HM, Aydin E, Saglam O, Torun A, Guzeloglu-Kayisli O, Lalioti MD, Kristiansson H, Duke CM, Choe G, Flannery C, Kallen CB, Seli E: mRNA-binding protein TIA-1 reduces cytokine expression in human endometrial stromal cells and is down-regulated in ectopic endometrium. J Clin Endocrinol Metab. 2014 Dec. PMID: 25140393

Flannery CA, Rackow B, Cong X, Duran E, Selen DJ, Burgert TS: Polycystic ovary syndrome in adolescence: impaired glucose tolerance occurs across the spectrum of BMI. Pediatr Diabetes. 2013 Feb; 2012 Aug 28. PMID: 22925367

Flannery C, Dufour S, Rabøl R, Shulman GI, Petersen KF: Skeletal muscle insulin resistance promotes increased hepatic de novo lipogenesis, hyperlipidemia, and hepatic steatosis in the elderly. Diabetes. 2012 Nov; 2012 Jul 24. PMID: 22829450

Rabøl R, Petersen KF, Dufour S, Flannery C, Shulman GI: Reversal of muscle insulin resistance with exercise reduces postprandial hepatic de novo lipogenesis in insulin resistant individuals. Proc Natl Acad Sci U S A. 2011 Aug 16; 2011 Aug 1. PMID: 21808028

Erion DM, Ignatova ID, Yonemitsu S, Nagai Y, Chatterjee P, Weismann D, Hsiao JJ, Zhang D, Iwasaki T, Stark R, Flannery C, Kahn M, Carmean CM, Yu XX, Murray SF, Bhanot S, Monia BP, Cline GW, Samuel VT, Shulman GI: Prevention of hepatic steatosis and hepatic insulin resistance by knockdown of cAMP response element-binding protein. Cell Metab. 2009 Dec. PMID: 19945407

Flannery Lab Photos

Flannery Lab Group Photo 1
Left to right:  Clare Flannery, Katie Radford, Nigar Sofiyeva, Katie Cooke, Farrah Saleh
Flannery Lab Group Photo 2

Left to right: Clare Flannery,  Nigar Sofiyeva, Katie Cooke

Flannery Lab Alumni

- Nigar Sofiyeva, MD

- Caitlin Radford, BA

- Milana Bochkur Dratver, BS, MA

- Chayma Boussard, BS

- Christina Wong, BS

- Andrew Fleming, BS

- Katherine Araque, MD

- Anu Sharma, MD

- Georgia Holland, BS

- Margaret Zhang, BS

- Gina Choe, BS

- Emily Turner, MD

- Elizabeth Oliver, MS

- Ruth Lauder, MS

- Daryl Selen, BA

- Jhenette Lauder, BS