Dr. Tal's Lab

Research Interests

Dr. Tal’s lab studies the role of stem cells in reproductive physiology and pathology. Bone marrow-derived stem cells have been shown to migrate to the uterus where they differentiate into non-hematopoietic lineages within the endometrium. Dr. Tal’s research aims to understand the importance of this phenomenon and elucidate its underlying mechanisms. Dr. Tal’s lab has developed a non-gonadotoxic bone marrow transplant regimen and ongoing investigations use transgenic/knockout mouse models and molecular techniques to characterize the contribution of these stem cells and their functional role in reproduction. The Tal lab translational focus is on recurrent implantation failure and recurrent pregnancy loss.

Lab Members

Lab Members
Bio Profile

Reshef Tal, MD, PhD

Assistant Professor of Obstetrics, Gynecology & Reproductive Sciences

Research Interests

Angiogenesis Modulating Agents; Anti-Mullerian Hormone; Embryo Implantation; Endometrium; Polycystic Ovary Syndrome; Regenerative Medicine; Stem Cells

Clinical Interests

Infertility; Menstruation Disturbances; Polycystic Ovary Syndrome

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Publications

Tal A, Tal R, Pluchino N, Taylor HS: Endometrial cells contribute to preexisting endometriosis lesions in a mouse model of retrograde menstruation†. Biol Reprod. 2019 Jun 1. PMID: 30869747

Granger E, Tal R: Anti-Müllerian Hormone and Its Predictive Utility in Assisted Reproductive Technologies Outcomes. Clin Obstet Gynecol. 2019 Jun. PMID: 30994481

Tal R, Dong D, Shaikh S, Mamillapalli R, Taylor HS: Bone-marrow-derived endothelial progenitor cells contribute to vasculogenesis of pregnant mouse uterus†. Biol Reprod. 2019 May 1. PMID: 30601943

Yi KW, Mamillapalli R, Sahin C, Song J, Tal R, Taylor HS: Bone marrow-derived cells or C-X-C motif chemokine 12 (CXCL12) treatment improve thin endometrium in a mouse model. Biol Reprod. 2019 Jan 1. PMID: 30084961

Pluchino N, Mamillapalli R, Moridi I, Tal R, Taylor HS: G-Protein-Coupled Receptor CXCR7 Is Overexpressed in Human and Murine Endometriosis. Reprod Sci. 2018 Aug; 2018 Mar 27. PMID: 29587613

Mor A, Tal R, Haberman S, Kalgi B, Nasab SH, Minkoff H: Same-day confirmation of intrauterine pregnancy failure in women with first- and early second-trimester bleeding. Fertil Steril. 2018 Jun. PMID: 29935643

Kliman HJ, Quaratella SB, Setaro AC, Siegman EC, Subha ZT, Tal R, Milano KM, Steck TL: Pathway of Maternal Serotonin to the Human Embryo and Fetus. Endocrinology. 2018 Apr 1. PMID: 29381782

Tal R, Seifer DB, Wantman E, Baker V, Tal O: Antimüllerian hormone as a predictor of live birth following assisted reproduction: an analysis of 85,062 fresh and thawed cycles from the Society for Assisted Reproductive Technology Clinic Outcome Reporting System database for 2012-2013. Fertil Steril. 2018 Feb; 2018 Jan 11. PMID: 29331235

Liu Y, Tal R, Pluchino N, Mamillapalli R, Taylor HS: Systemic administration of bone marrow-derived cells leads to better uterine engraftment than use of uterine-derived cells or local injection. J Cell Mol Med. 2018 Jan; 2017 Aug 7. PMID: 28782281

Liu W, Tal R, Chao H, Liu M, Liu Y: Effect of local endometrial injury in proliferative vs. luteal phase on IVF outcomes in unselected subfertile women undergoing in vitro fertilization. Reprod Biol Endocrinol. 2017 Sep 22; 2017 Sep 22. PMID: 28938896

Tal R, Seifer DB: Ovarian reserve testing: a user's guide. Am J Obstet Gynecol. 2017 Aug; 2017 Feb 21. PMID: 28235465

Irani M, Seifer DB, Grazi RV, Irani S, Rosenwaks Z, Tal R: Vitamin D Decreases Serum VEGF Correlating with Clinical Improvement in Vitamin D-Deficient Women with PCOS: A Randomized Placebo-Controlled Trial. Nutrients. 2017 Mar 28; 2017 Mar 28. PMID: 28350328

Sahin Ersoy G, Kurek Eken M, Cevik O, Cilingir OT, Tal R: Mycophenolate mofetil attenuates uterine ischaemia/reperfusion injury in a rat model. Reprod Biomed Online. 2017 Feb; 2016 Nov 21. PMID: 27913135

Pluchino N, Wenger JM, Petignat P, Tal R, Bolmont M, Taylor HS, Bianchi-Demicheli F: Sexual function in endometriosis patients and their partners: effect of the disease and consequences of treatment. Hum Reprod Update. 2016 Nov; 2016 Sep 2. PMID: 27591248

Yoder N, Tal R, Martin JR: Abdominal ectopic pregnancy after in vitro fertilization and single embryo transfer: a case report and systematic review. Reprod Biol Endocrinol. 2016 Oct 19; 2016 Oct 19. PMID: 27760569

Tal R, Liu Y, Pluchino N, Shaikh S, Mamillapalli R, Taylor HS: A Murine 5-Fluorouracil-Based Submyeloablation Model for the Study of Bone Marrow-Derived Cell Trafficking in Reproduction. Endocrinology. 2016 Oct; 2016 Jul 18. PMID: 27427897

Garg D, Tal R: The role of AMH in the pathophysiology of polycystic ovarian syndrome. Reprod Biomed Online. 2016 Jul; 2016 Apr 21. PMID: 27174394

Sahin Ersoy G, Eken M, Tal R, Oztekin D, Devranoglu B, Isik Kaygusuz E, Cevik O: N-acetylcysteine leads to greater ovarian protection than enoxaparin sodium in a rat ovarian torsion model. Reprod Biomed Online. 2016 Jul; 2016 Apr 7. PMID: 27083693

Mor A, Tal R, Irani M, McCalla S, Haberman S, Garg D, Wajntraub B: Carcinoembryonic antigen as a biomarker for meconium-stained amniotic fluid. Int J Gynaecol Obstet. 2016 Mar; 2015 Nov 26. PMID: 26674317

Garg D, Tal R: Inositol Treatment and ART Outcomes in Women with PCOS. Int J Endocrinol. 2016; 2016 Oct 4. PMID: 27795706

Tal R, Taylor HS, Burney RO, Mooney SB, Giudice LC, Feingold KR, Anawalt B, Boyce A, Chrousos G, Dungan K, Grossman A, Hershman JM, Kaltsas G, Koch C, Kopp P, Korbonits M, McLachlan R, Morley JE, New M, Perreault L, Purnell J, Rebar R, Singer F, Trence DL, Vinik A, Wilson DP: Endocrinology of Pregnancy 2000. PMID: 25905197

Huang X, Wang P, Tal R, Lv F, Li Y, Zhang X: A systematic review and meta-analysis of metformin among patients with polycystic ovary syndrome undergoing assisted reproductive technology procedures. Int J Gynaecol Obstet. 2015 Nov; 2015 Jul 23. PMID: 26304048

Irani M, Seifer DB, Grazi RV, Julka N, Bhatt D, Kalgi B, Irani S, Tal O, Lambert-Messerlian G, Tal R: Vitamin D Supplementation Decreases TGF-β1 Bioavailability in PCOS: A Randomized Placebo-Controlled Trial. J Clin Endocrinol Metab. 2015 Nov; 2015 Oct 20. PMID: 26485217

Seifer DB, Tal R: Personalized prediction of live birth: Are we there yet? Fertil Steril. 2015 Aug; 2015 Jun 3. PMID: 26049289

Mor A, Fuchs Y, Zafra K, Haberman S, Tal R: Acute presentation of gestational diabetes insipidus with pre-eclampsia complicated by cerebral vasoconstriction: a case report and review of the published work. J Obstet Gynaecol Res. 2015 Aug; 2015 Apr 1. PMID: 25832854

Tal R, Seifer DB, Arici A: The emerging role of angiogenic factor dysregulation in the pathogenesis of polycystic ovarian syndrome. Semin Reprod Med. 2015 May; 2015 Jun 2. PMID: 26036901

Mor A, Tal R, Haberman S, McCalla S, Irani M, Perlman J, Seifer DB, Minkoff H: Alpha-fetoprotein as a tool to distinguish amniotic fluid from urine, vaginal discharge, and semen. Obstet Gynecol. 2015 Feb. PMID: 25569004

Tal R, Tal O, Seifer BJ, Seifer DB: Antimüllerian hormone as predictor of implantation and clinical pregnancy after assisted conception: a systematic review and meta-analysis. Fertil Steril. 2015 Jan; 2014 Oct 24. PMID: 25450298

Tal R, Seifer DB, Grazi RV, Malter HE: Follicular fluid placental growth factor is increased in polycystic ovarian syndrome: correlation with ovarian stimulation. Reprod Biol Endocrinol. 2014 Aug 20; 2014 Aug 20. PMID: 25141961

Tal R, Seifer DB, Khanimov M, Malter HE, Grazi RV, Leader B: Characterization of women with elevated antimüllerian hormone levels (AMH): correlation of AMH with polycystic ovarian syndrome phenotypes and assisted reproductive technology outcomes. Am J Obstet Gynecol. 2014 Jul; 2014 Mar 2. PMID: 24593938

Tal R, Segars JH: The role of angiogenic factors in fibroid pathogenesis: potential implications for future therapy. Hum Reprod Update. 2014 Mar-Apr; 2013 Sep 29. PMID: 24077979

Irani M, Tal R, Seifer DB, Grazi RV: Successful Same-Cycle Blastocyst Transfer following Laparoscopic Ovarian Detorsion: A Report of Two Cases and Literature Review. Case Rep Obstet Gynecol. 2014; 2014 Apr 29. PMID: 24864219

Sharma H, Tal R, Clark NA, Segars JH: Microbiota and pelvic inflammatory disease. Semin Reprod Med. 2014 Jan; 2014 Jan 3. PMID: 24390920

Tal R, Seifer DB, Grazi RV, Malter HE: Angiopoietin-1 and angiopoietin-2 are altered in polycystic ovarian syndrome (PCOS) during controlled ovarian stimulation. Vasc Cell. 2013 Oct 24; 2013 Oct 24. PMID: 24156373

Tal R, Seifer DB, Shohat-Tal A, Grazi RV, Malter HE: Transforming growth factor-β1 and its receptor soluble endoglin are altered in polycystic ovary syndrome during controlled ovarian stimulation. Fertil Steril. 2013 Aug; 2013 May 15. PMID: 23684116

Tal R, Seifer DB, Khanimov M, Schwartz E, Grazi RV, Malter HE: Anti-Müllerian hormone as an independent predictor of twin versus singleton pregnancy in fresh cycles. Reprod Biomed Online. 2013 Apr; 2012 Dec 19. PMID: 23419793

Tal R, Seifer DB: Potential mechanisms for racial and ethnic differences in antimüllerian hormone and ovarian reserve. Int J Endocrinol. 2013; 2013 Nov 21. PMID: 24348557

Tal R: The role of hypoxia and hypoxia-inducible factor-1alpha in preeclampsia pathogenesis. Biol Reprod. 2012 Jun; 2012 Dec 13. PMID: 23034156

Tal R, Fridman D, Grazi RV: Monozygotic Triplets and Dizygotic Twins following Transfer of Three Poor-Quality Cleavage Stage Embryos. Case Rep Obstet Gynecol. 2012; 2012 Dec 24. PMID: 23320217

Tal R, Shaish A, Barshack I, Polak-Charcon S, Afek A, Volkov A, Feldman B, Avivi C, Harats D: Effects of hypoxia-inducible factor-1alpha overexpression in pregnant mice: possible implications for preeclampsia and intrauterine growth restriction. Am J Pathol. 2010 Dec; 2010 Oct 15. PMID: 20952590

Rolfo A, Many A, Racano A, Tal R, Tagliaferro A, Ietta F, Wang J, Post M, Caniggia I: Abnormalities in oxygen sensing define early and late onset preeclampsia as distinct pathologies. PLoS One. 2010 Oct 12; 2010 Oct 12. PMID: 20967267

Shmilovich H, Ben-Shoshan J, Tal R, Afek A, Barshack I, Maysel-Auslander S, Harats D, Keren G, George J: B-type natriuretic peptide enhances vasculogenesis by promoting number and functional properties of early endothelial progenitor cells. Tissue Eng Part A. 2009 Sep. PMID: 19275472

Hodish I, Tal R, Shaish A, Varda-Bloom N, Greenberger S, Rauchwerger A, Breitbart E, Bangio L, Ben-Shushan D, Pfeffer R, Feder B, Waitsman A, Barshack I, Goldberg I, Mazaki-Tovi S, Peled M, Harats D: Systemic administration of radiation-potentiated anti-angiogenic gene therapy against primary and metastatic cancer based on transcriptionally controlled HSV-TK. Cancer Biol Ther. 2009 Mar; 2009 Mar 19. PMID: 19276657

Peled M, Shaish A, Katav A, Greenberger S, Barshack I, Tal R, Bangio L, Breitbart E, Harats D: Systemic administration of a conditionally replicating adenovirus, targeted to angiogenesis, reduced lung metastases burden in cotton rats. Clin Cancer Res. 2009 Mar 1; 2009 Feb 24. PMID: 19240175

Tal R, Shaish A, Rofe K, Feige E, Varda-Bloom N, Afek A, Barshack I, Bangio L, Hodish I, Greenberger S, Peled M, Breitbart E, Harats D: Endothelial-targeted Gene Transfer of Hypoxia-inducible Factor-1α Augments Ischemic Neovascularization Following Systemic Administration. Mol Ther. 2008 Dec; 2016 Dec 8. PMID: 28189008

Tal R, Shaish A, Rofe K, Feige E, Varda-Bloom N, Afek A, Barshack I, Bangio L, Hodish I, Greenberger S, Peled M, Breitbart E, Harats D: Endothelial-targeted gene transfer of hypoxia-inducible factor-1alpha augments ischemic neovascularization following systemic administration. Mol Ther. 2008 Dec; 2008 Sep 16. PMID: 18797451

Tal R, Shaish A, Bangio L, Peled M, Breitbart E, Harats D: Activation of C-transactivation domain is essential for optimal HIF-1 alpha-mediated transcriptional and angiogenic effects. Microvasc Res. 2008 May; 2008 Mar 20. PMID: 18440561

Barsheshet A, Hod H, Shechter M, Sharabani-Yosef O, Rosenthal E, Barbash IM, Matetzky S, Tal R, Bentancur AG, Sela BA, Nagler A, Leor J: The effects of external counter pulsation therapy on circulating endothelial progenitor cells in patients with angina pectoris. Cardiology. 2008; 2007 Dec 4. PMID: 18057883

Peled M, Shaish A, Frishman L, Cohen H, Tal R, Harats D: Endothelin B receptor antagonist increases preproendothelin-1 transcription in bovine aortic endothelial cells and in vivo. J Cardiovasc Pharmacol. 2006 May. PMID: 16775506