2020
Ovarian BDNF promotes survival, migration, and attachment of tumor precursors originated from p53 mutant fallopian tube epithelial cells
Kang M, Chong KY, Hartwich TMP, Bi F, Witham AK, Patrick D, Morrisson MJ, Cady SL, Cerchia AP, Kelk D, Liu Y, Nucci J, Madarikan O, Ueno D, Shuch BM, Yang-Hartwich Y. Ovarian BDNF promotes survival, migration, and attachment of tumor precursors originated from p53 mutant fallopian tube epithelial cells. Oncogenesis 2020, 9: 55. PMID: 32471985, PMCID: PMC7260207, DOI: 10.1038/s41389-020-0243-y.Peer-Reviewed Original ResearchHigh-grade serous ovarian carcinomaBrain-derived neurotrophic factorFallopian tube epitheliumFTE cellsTumor precursorsPathophysiological processesTropomyosin receptor kinase BFallopian tube epithelial cellsBDNF/TrkBReceptor kinase BLethal gynecological malignancyGenetic alterationsSerous ovarian carcinomaFunction mutationsCommon TP53Gynecological malignanciesNeurotrophic factorFallopian tubeOvarian carcinomaRisk factorsFollicular fluidMutant p53 proteinVivo modelTP53 lossEpithelial cells
2014
Ovulation and extra-ovarian origin of ovarian cancer
Yang-Hartwich Y, Gurrea-Soteras M, Sumi N, Joo WD, Holmberg JC, Craveiro V, Alvero AB, Mor G. Ovulation and extra-ovarian origin of ovarian cancer. Scientific Reports 2014, 4: 6116. PMID: 25135607, PMCID: PMC4137344, DOI: 10.1038/srep06116.Peer-Reviewed Original ResearchConceptsOvarian cancerExtra-ovarian originMalignant cellsChemokines/cytokinesOvarian surface epitheliumBetter prevention strategiesPotential molecular mechanismsFallopian tubeLate diagnosisOvarian localizationGastrointestinal tractSDF-1Mortality ratePrevention strategiesSurface epitheliumMain chemoattractantVivo modelLethal diseaseEx vivoCancerEarly detectionSpecific markersOvulationOvariesTumors