2020
Acetaminophen Attenuates invasion and alters the expression of extracellular matrix enzymes and vascular factors in human first trimester trophoblast cells
Burman A, Garcia-Milian R, Wood M, DeWitt NA, Vasiliou V, Guller S, Abrahams VM, Whirledge S. Acetaminophen Attenuates invasion and alters the expression of extracellular matrix enzymes and vascular factors in human first trimester trophoblast cells. Placenta 2020, 104: 146-160. PMID: 33348283, DOI: 10.1016/j.placenta.2020.12.002.Peer-Reviewed Original ResearchConceptsFirst trimester trophoblast cellsHuman first trimester trophoblast cellsPrenatal acetaminophen useTrophoblast cellsAcetaminophen useTrophoblast functionsAcetaminophen exposureFetal developmentHTR-8/SVneo cellsPrenatal acetaminophen exposureAnti-inflammatory drug aspirinRecent epidemiological studiesPlacental cell typesMatrix metalloproteinases 2Expression of angiogenesisExtracellular matrix enzymesPrenatal acetaminophenCommon medicationsVascular factorsMaternal healthPlacental functionEpidemiological associationLong-term effectsCyclooxygenase-1Epidemiological studies
2005
Thrombin-dependent regulation of matrix metalloproteinase (MMP)-9 levels in human fetal membranes*
Stephenson CD, Lockwood CJ, Ma Y, Guller S. Thrombin-dependent regulation of matrix metalloproteinase (MMP)-9 levels in human fetal membranes*. The Journal Of Maternal-Fetal & Neonatal Medicine 2005, 18: 17-22. PMID: 16105787, DOI: 10.1080/14767050500123632.Peer-Reviewed Original ResearchConceptsMMP-9 levelsMMP-9MMP-1Matrix metalloproteinaseAmniochorionic membranesThrombin receptor agonist peptidePreterm premature ruptureAnti-inflammatory steroidsMajor risk factorMMP-9 expressionThrombin treatmentThrombin receptor agonistPresence of lipopolysaccharideHuman fetal membranesPremature ruptureReceptor agonistRisk factorsSuch hemorrhageDEX treatmentMMP levelsTIMP-1Thrombin receptorTissue inhibitorAgonist peptideFetal membranes