2014
Syncytiotrophoblast Vesicles Show Altered micro-RNA and Haemoglobin Content after Ex-vivo Perfusion of Placentas with Haemoglobin to Mimic Preeclampsia
Cronqvist T, Saljé K, Familari M, Guller S, Schneider H, Gardiner C, Sargent IL, Redman CW, Mörgelin M, Åkerström B, Gram M, Hansson SR. Syncytiotrophoblast Vesicles Show Altered micro-RNA and Haemoglobin Content after Ex-vivo Perfusion of Placentas with Haemoglobin to Mimic Preeclampsia. PLOS ONE 2014, 9: e90020. PMID: 24587192, PMCID: PMC3937405, DOI: 10.1371/journal.pone.0090020.Peer-Reviewed Original ResearchConceptsPathology of preeclampsiaCell-free HbMiR-517bMiR-517aSyncytiotrophoblast vesiclesExtracellular free hemoglobinPerfusion of placentaEx vivo perfusion systemMicro-RNAsMaternal circulationMimic preeclampsiaMaternal sidePerfusion mediumFree hemoglobinHuman placentaPerfusion phaseSurface markersPlacentaMiR-141Hemoglobin contentPerfusionPerfusion systemPreeclampsiaHemoglobinQuantitative PCR
2005
Expression and Regulation of Glucocorticoid Receptor in Human Placental Villous Fibroblasts
Lee MJ, Wang Z, Yee H, Ma Y, Swenson N, Yang L, Kadner SS, Baergen RN, Logan SK, Garabedian MJ, Guller S. Expression and Regulation of Glucocorticoid Receptor in Human Placental Villous Fibroblasts. Endocrinology 2005, 146: 4619-4626. PMID: 16055431, DOI: 10.1210/en.2005-0235.Peer-Reviewed Original ResearchConceptsGC receptorSmooth muscle cellsHuman placentaGR levelsHormone treatmentShort-term GC treatmentMuscle cellsLong-term hormone treatmentVascular smooth muscle cellsGR protein expressionGR mRNA levelsPlacental cell typesNormal term human placentasTotal GR levelsTerm human placentaCell typesGR antibodyGC treatmentHormone exposureStem villiCytotrophoblast cellsGlucocorticoid receptorPlacental fibroblastsTerminal villiVillous fibroblasts
1999
Steroid Regulation of Human Placental Integrins: Suppression ofα 2 Integrin Expression in Cytotrophoblasts by Glucocorticoids1
Ryu J, Majeska R, Ma Y, LaChapelle L, Guller S. Steroid Regulation of Human Placental Integrins: Suppression ofα 2 Integrin Expression in Cytotrophoblasts by Glucocorticoids1. Endocrinology 1999, 140: 3904-3908. DOI: 10.1210/en.140.9.3904.Peer-Reviewed Original ResearchExtracellular matrix ligandsHuman cytotrophoblastsControl levelsMessenger RNATreatment of cytotrophoblastsMRNA levelsIntegrin subunitsCell surface expressionHuman term placentaExtracellular matrixDays of treatmentHuman pregnancyExpression of collagenHeterodimeric transmembrane glycoproteinsTerm placentaCytotrophoblastDexamethasone effectDown-regulated expressionHuman placentaSurface expressionCellular adhesion receptorsDexamethasoneGC treatmentGlucocorticoidIntegrin levels