2018
Glucocorticoid signaling regulates cell invasion and migration in the human first‐trimester trophoblast cell line Sw.71
Kisanga EP, Tang Z, Guller S, Whirledge S. Glucocorticoid signaling regulates cell invasion and migration in the human first‐trimester trophoblast cell line Sw.71. American Journal Of Reproductive Immunology 2018, 80: e12974. PMID: 29774963, DOI: 10.1111/aji.12974.Peer-Reviewed Original ResearchConceptsGene expression profilesSERPINE1 promoterPolymerase IITranscriptional regulationGlucocorticoid receptorCell movementTranscriptional profilesGlucocorticoid treatmentExpression profilesMicroarray analysisStress responseCell invasionPrimary mediatorPathogenesis of preeclampsiaCell proliferationEffects of glucocorticoidsExtravillous trophoblast functionsGlucocorticoid signalingSynthetic glucocorticoid dexamethasoneGenesTrophoblast functionsAdrenal axisInvasionTrophoblast tissueGlucocorticoid dexamethasone
2016
Optimization of techniques for multiple platform testing in small, precious samples such as human chorionic villus sampling
Pisarska MD, Akhlaghpour M, Lee B, Barlow GM, Xu N, Wang ET, Mackey AJ, Farber CR, Rich SS, Rotter JI, Chen Y, Goodarzi MO, Guller S, Williams J. Optimization of techniques for multiple platform testing in small, precious samples such as human chorionic villus sampling. Prenatal Diagnosis 2016, 36: 1061-1070. PMID: 27718505, PMCID: PMC5142835, DOI: 10.1002/pd.4936.Peer-Reviewed Original ResearchConceptsGenome-wide methylation profilingRNA-seq librariesSystems biology approachGene expression studiesBiology approachEpigenetic modificationsLow DNA yieldRNA sequencingMethylation profilingExpression studiesGene expressionPurification of DNAQuality DNAGlobal changeHighest RNA yieldDNA yieldRNA yieldRNADNAIsolation kitRNAlater samplesRNAlaterGenesChorionic villiMultiple testing