2004
Estrogen to Antiestrogen with a Single Methylene Group Resulting in an Unusual Steroidal Selective Estrogen Receptor Modulator
Zhang JX, Labaree DC, Mor G, Hochberg RB. Estrogen to Antiestrogen with a Single Methylene Group Resulting in an Unusual Steroidal Selective Estrogen Receptor Modulator. The Journal Of Clinical Endocrinology & Metabolism 2004, 89: 3527-3535. PMID: 15240642, DOI: 10.1210/jc.2003-032005.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBody WeightBone and BonesCell Line, TumorCholesterolDose-Response Relationship, DrugEstradiolEstrogen AntagonistsEstrogen Receptor alphaEstrogen Receptor betaEstrogensFemaleHumansHydrocarbonsMethaneOrgan SizeRatsRats, Sprague-DawleyReceptors, EstrogenSelective Estrogen Receptor ModulatorsTransfectionUterusConceptsSelective estrogen receptor modulatorsEstrogen receptor modulatorsReceptor modulatorsBreast cancer preventionEstradiol-induced proliferationER affinityHigh ER affinityImportant therapeutic agentsPlasma cholesterolER alphaCancer preventionEstrogen agonistEstrogenic agonistTherapeutic agentsEstradiol analogsHigh estrogenic potencyCell bioassayBone growthEstrogenic activityAntiestrogensEstrogenic potencyAgonistsCritical structuresUnique mechanismGroup
2003
Synthesis and Evaluation of B-, C-, and D-Ring-Substituted Estradiol Carboxylic Acid Esters as Locally Active Estrogens
Labaree DC, Zhang JX, Harris HA, O'Connor C, Reynolds TY, Hochberg RB. Synthesis and Evaluation of B-, C-, and D-Ring-Substituted Estradiol Carboxylic Acid Esters as Locally Active Estrogens. Journal Of Medicinal Chemistry 2003, 46: 1886-1904. PMID: 12723952, DOI: 10.1021/jm0204340.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBinding, CompetitiveEsterasesEstersEstradiolEstradiol CongenersEstrogen Receptor alphaEstrogen Receptor betaFemaleHumansIn Vitro TechniquesKidneyLigandsMiceMicrosomesOrgan SizeOxidoreductasesRatsRats, Sprague-DawleyReceptors, EstrogenStructure-Activity RelationshipTumor Cells, CulturedUterusVaginaConceptsEstrogen receptorHormonal activityReceptor bindingAnalogues of estradiolEstrogen-sensitive genesEstrogen receptor bindingEstrogen-responsive genesEstrogenic actionIshikawa cellsEffective estrogenActive estrogensEstrogenHormonal actionDerivatives of estradiolEstradiolEstrogenic responsesSystemic actionReceptorsEstrogenic activityVivo assaysNonspecific esterasesSteroid nucleusSensitive genesActivitySteroid ring
1995
Long-lived testosterone esters in the rat.
Borg W, Shackleton CH, Pahuja SL, Hochberg RB. Long-lived testosterone esters in the rat. Proceedings Of The National Academy Of Sciences Of The United States Of America 1995, 92: 1545-1549. PMID: 7878017, PMCID: PMC42556, DOI: 10.1073/pnas.92.5.1545.Peer-Reviewed Original ResearchConceptsTestosterone estersPresence of testosteronePotent therapeutic agentLong-term castratesFemale ratsMale ratsTestosterone levelsMeasurable fallEster fractionIntact malesSteroid hormonesTherapeutic agentsRatsHormonal potencyTarget tissuesImportant physiological impactAndrogensFatTestosteroneMost tissuesCastrationTissueFatty acidsTestosterone equivalentsPhysiological impact
1992
Estrogen receptors colocalize with low-affinity nerve growth factor receptors in cholinergic neurons of the basal forebrain.
Toran-Allerand CD, Miranda RC, Bentham WD, Sohrabji F, Brown TJ, Hochberg RB, MacLusky NJ. Estrogen receptors colocalize with low-affinity nerve growth factor receptors in cholinergic neurons of the basal forebrain. Proceedings Of The National Academy Of Sciences Of The United States Of America 1992, 89: 4668-4672. PMID: 1316615, PMCID: PMC49144, DOI: 10.1073/pnas.89.10.4668.Peer-Reviewed Original ResearchConceptsLow-affinity nerve growth factor receptorNerve growth factor receptorGrowth factor receptorBasal forebrainCholinergic neuronsSame neuronsFactor receptorCholinergic marker enzyme choline acetyltransferaseGonadal steroid hormone estrogenBrain-derived neurotrophic factorPrimate basal forebrainRodent basal forebrainSteroid hormone estrogenEnzyme choline acetyltransferaseNerve growth factorSitu hybridization histochemistryEstrogen deficiencyNeurotrophic factorNeurotrophin-3Cholinergic functionCholine acetyltransferaseNeuronal survivalHormone estrogenEstrogen receptorClinical conditions
1989
The synthesis of 11 beta-methoxy-[16 alpha-123I] iodoestradiol and its interaction with the estrogen receptor in vivo and in vitro.
Zielinski JE, Larner JM, Hoffer PB, Hochberg RB. The synthesis of 11 beta-methoxy-[16 alpha-123I] iodoestradiol and its interaction with the estrogen receptor in vivo and in vitro. Journal Of Nuclear Medicine 1989, 30: 209-15. PMID: 2738649.Peer-Reviewed Original Research