2018
Measurement of compensatory reserve predicts racial differences in tolerance to simulated hemorrhage in women
Wenner MM, Hinds KA, Howard JT, Nawn CD, Stachenfeld NS, Convertino VA. Measurement of compensatory reserve predicts racial differences in tolerance to simulated hemorrhage in women. Journal Of Trauma And Acute Care Surgery 2018, 85: s77-s83. PMID: 29443858, PMCID: PMC6023758, DOI: 10.1097/ta.0000000000001837.Peer-Reviewed Original ResearchConceptsLower body negative pressureBeat blood pressureHg lower body negative pressureCentral blood volumeCompensatory reserve measurementHeart rateWhite womenBlood volumeProgressive lower body negative pressureInadequate tissue oxygenationSigns/symptomsBody negative pressureProgressive central hypovolemiaRacial differencesStandard vital signsAfrican American womenBlood pressureHemodynamic decompensationAA womenCentral hypovolemiaRetrospective analysisTissue oxygenationRate of declineHemorrhageNegative pressure
2001
Progesterone does not alter osmotic regulation of AVP
Calzone W, Silva C, Keefe D, Stachenfeld N. Progesterone does not alter osmotic regulation of AVP. AJP Regulatory Integrative And Comparative Physiology 2001, 281: r2011-r2020. PMID: 11705788, DOI: 10.1152/ajpregu.2001.281.6.r2011.Peer-Reviewed Original ResearchConceptsHypertonic saline infusionLuteal phaseOral contraceptivesFollicular phaseOsmotic thresholdThirst onsetRenal free water clearanceLow osmotic thresholdFree water clearancePlasma AVP concentrationArginine vasopressin releaseBaseline plasma osmolalityBody water balanceMenstrual cycleMidluteal phaseWater clearanceSaline infusionAVP releaseAVP concentrationMenstrual phaseVasopressin releaseFluid balanceOC treatmentThirst responseCrossover designEstrogen and progesterone effects on transcapillary fluid dynamics
Stachenfeld N, Keefe D, Palter S. Estrogen and progesterone effects on transcapillary fluid dynamics. AJP Regulatory Integrative And Comparative Physiology 2001, 281: r1319-r1329. PMID: 11557642, DOI: 10.1152/ajpregu.2001.281.4.r1319.Peer-Reviewed Original ResearchMeSH KeywordsAdultAtrial Natriuretic FactorBlood PressureBlood VolumeCapillariesCapillary PermeabilityCardiac OutputDrug Administration RoutesEstradiolEstrogensFemaleFertility Agents, FemaleForearmGonadotropin-Releasing HormoneHematocritHot FlashesHumansInfusions, IntravenousLeuprolideProgesteroneStroke VolumeVeinsConceptsCapillary filtration coefficientANP infusionGnRH analoguesPlasma volumeProgesterone effectsTranscapillary fluid dynamicsGonadotropin-releasing hormone analogueLittle systemic effectMin of infusionBaseline plasma volumeHormone administrationPV lossSystemic effectsReproductive functionInfusionAdministrationTreatmentEstrogenPeptide controlFiltration coefficientWeeksWomenANPDaysHematocritSelected Contribution: Sex differences in osmotic regulation of AVP and renal sodium handling
Stachenfeld N, Splenser A, Calzone W, Taylor M, Keefe D. Selected Contribution: Sex differences in osmotic regulation of AVP and renal sodium handling. Journal Of Applied Physiology 2001, 91: 1893-1901. PMID: 11568177, DOI: 10.1152/jappl.2001.91.4.1893.Peer-Reviewed Original ResearchConceptsSystolic blood pressureBlood pressureMenstrual phaseBasal plasma AVP concentrationGreater systolic blood pressurePressure-natriuresis curveRenal sodium handlingPlasma osmolalityPlasma AVP concentrationMin of restMidluteal menstrual phasesBasal plasma osmolalitySex differencesSodium handlingPulse pressureBody wtAVP concentrationAVP releaseNaCl infusionHormone responseMenWomenGreater sensitivityBody waterOsmolality
1999
Effects of oral contraceptives on body fluid regulation
Stachenfeld N, Silva C, Keefe D, Kokoszka C, Nadel E. Effects of oral contraceptives on body fluid regulation. Journal Of Applied Physiology 1999, 87: 1016-1025. PMID: 10484572, DOI: 10.1152/jappl.1999.87.3.1016.Peer-Reviewed Original ResearchConceptsBody fluid regulationLuteal phaseHighest plasma estradiol concentrationFluid regulationOral contraceptive administrationBody fluid retentionPlasma estradiol concentrationsMidluteal menstrual phasesBody fluid balanceArginine vasopressin concentrationBasal plasma osmolalityExercise dehydrationOral contraceptivesContraceptive administrationBody water balanceFluid retentionFollicular phaseEstradiol concentrationsAVP releaseMenstrual phaseFluid balanceVasopressin concentrationCrossover designThirst stimulationPlasma osmolality
1997
Mechanism of attenuated thirst in aging: role of central volume receptors
Stachenfeld N, DiPietro L, Nadel E, Mack G. Mechanism of attenuated thirst in aging: role of central volume receptors. American Journal Of Physiology 1997, 272: r148-r157. PMID: 9039003, DOI: 10.1152/ajpregu.1997.272.1.r148.Peer-Reviewed Original ResearchConceptsCentral blood volume expansionBlood volume expansionYoung subjectsOlder subjectsPlasma volumePlasma atrial natriuretic peptide concentrationAtrial natriuretic peptide concentrationsThirst ratingsOlder peopleFractional sodium excretionPlasma renin activityArterial blood pressureNatriuretic peptide concentrationsCentral volume expansionMin of headWater perfusion suitAd libitum water intakeAldosterone concentrationRenin activitySodium excretionArterial baroreceptorsArterial pressureBlood pressureRenal responseVolume receptors