2014
The Interrelationship of Research in the Laboratory and the Field to Assess Hydration Status and Determine Mechanisms Involved in Water Regulation During Physical Activity
Stachenfeld NS. The Interrelationship of Research in the Laboratory and the Field to Assess Hydration Status and Determine Mechanisms Involved in Water Regulation During Physical Activity. Sports Medicine 2014, 44: 97-104. PMID: 24791921, PMCID: PMC4008811, DOI: 10.1007/s40279-014-0155-0.Commentaries, Editorials and LettersHormonal Changes During Menopause and the Impact on Fluid Regulation
Stachenfeld NS. Hormonal Changes During Menopause and the Impact on Fluid Regulation. Reproductive Sciences 2014, 21: 555-561. PMID: 24492487, PMCID: PMC3984489, DOI: 10.1177/1933719113518992.Peer-Reviewed Original ResearchConceptsHormone therapySodium retentionMenopausal womenFluid regulationCardiovascular functionAldosterone-mediated sodium retentionRisk of hyponatremiaBlood pressure responseFemale reproductive hormonesFluid-regulating hormonesBody fluid volumeRisk of dehydrationBody fluid regulationEstrogen therapyHypervolemic hyponatremiaCardiovascular riskEstradiol effectsSodium loadProgesterone exposureMineralocorticoid receptorProgestogen exposureReproductive hormonesReproductive surgeryHormonal changesDistal tubules
2008
Acute Effects of Sodium Ingestion on Thirst and Cardiovascular Function
Stachenfeld NS. Acute Effects of Sodium Ingestion on Thirst and Cardiovascular Function. Current Sports Medicine Reports 2008, 7: s7-s13. PMID: 18843231, PMCID: PMC2871322, DOI: 10.1249/jsr.0b013e31817f23fc.Peer-Reviewed Original ResearchSex Hormone Effects on Body Fluid Regulation
Stachenfeld NS. Sex Hormone Effects on Body Fluid Regulation. Exercise And Sport Sciences Reviews 2008, 36: 152-159. PMID: 18580296, PMCID: PMC2849969, DOI: 10.1097/jes.0b013e31817be928.Peer-Reviewed Original Research
2002
Estrogen effects on osmotic regulation of AVP and fluid balance
Stachenfeld NS, Keefe DL. Estrogen effects on osmotic regulation of AVP and fluid balance. AJP Endocrinology And Metabolism 2002, 283: e711-e721. PMID: 12217888, DOI: 10.1152/ajpendo.00192.2002.Peer-Reviewed Original ResearchConceptsHormone treatmentEstrogen effectsPlasma renin activityFree water clearanceEnd of recoveryIntrarenal effectsRenal sensitivityRenin activitySodium excretionFractional excretionAVP increaseSodium retentionFluid retentionLeuprolide acetateWater clearanceEndogenous estrogensAldosterone stimulationFluid balanceGnRHaNaCl infusionPg/EstrogenAVPProgesteroneExcretion
2001
Progesterone does not alter osmotic regulation of AVP
Calzone W, Silva C, Keefe D, Stachenfeld N. Progesterone does not alter osmotic regulation of AVP. AJP Regulatory Integrative And Comparative Physiology 2001, 281: r2011-r2020. PMID: 11705788, DOI: 10.1152/ajpregu.2001.281.6.r2011.Peer-Reviewed Original ResearchConceptsHypertonic saline infusionLuteal phaseOral contraceptivesFollicular phaseOsmotic thresholdThirst onsetRenal free water clearanceLow osmotic thresholdFree water clearancePlasma AVP concentrationArginine vasopressin releaseBaseline plasma osmolalityBody water balanceMenstrual cycleMidluteal phaseWater clearanceSaline infusionAVP releaseAVP concentrationMenstrual phaseVasopressin releaseFluid balanceOC treatmentThirst responseCrossover design
1999
Effects of oral contraceptives on body fluid regulation
Stachenfeld N, Silva C, Keefe D, Kokoszka C, Nadel E. Effects of oral contraceptives on body fluid regulation. Journal Of Applied Physiology 1999, 87: 1016-1025. PMID: 10484572, DOI: 10.1152/jappl.1999.87.3.1016.Peer-Reviewed Original ResearchConceptsBody fluid regulationLuteal phaseHighest plasma estradiol concentrationFluid regulationOral contraceptive administrationBody fluid retentionPlasma estradiol concentrationsMidluteal menstrual phasesBody fluid balanceArginine vasopressin concentrationBasal plasma osmolalityExercise dehydrationOral contraceptivesContraceptive administrationBody water balanceFluid retentionFollicular phaseEstradiol concentrationsAVP releaseMenstrual phaseFluid balanceVasopressin concentrationCrossover designThirst stimulationPlasma osmolality
1997
Mechanism of attenuated thirst in aging: role of central volume receptors
Stachenfeld N, DiPietro L, Nadel E, Mack G. Mechanism of attenuated thirst in aging: role of central volume receptors. American Journal Of Physiology 1997, 272: r148-r157. PMID: 9039003, DOI: 10.1152/ajpregu.1997.272.1.r148.Peer-Reviewed Original ResearchConceptsCentral blood volume expansionBlood volume expansionYoung subjectsOlder subjectsPlasma volumePlasma atrial natriuretic peptide concentrationAtrial natriuretic peptide concentrationsThirst ratingsOlder peopleFractional sodium excretionPlasma renin activityArterial blood pressureNatriuretic peptide concentrationsCentral volume expansionMin of headWater perfusion suitAd libitum water intakeAldosterone concentrationRenin activitySodium excretionArterial baroreceptorsArterial pressureBlood pressureRenal responseVolume receptors
1996
Thirst and fluid regulatory responses to hypertonicity in older adults
Stachenfeld N, Mack G, Takamata A, DiPietro L, Nadel E. Thirst and fluid regulatory responses to hypertonicity in older adults. American Journal Of Physiology 1996, 271: r757-r765. PMID: 8853401, DOI: 10.1152/ajpregu.1996.271.3.r757.Peer-Reviewed Original Research
1995
Body temperature modification of osmotically induced vasopressin secretion and thirst in humans
Takamata A, Mack G, Stachenfeld N, Nadel E. Body temperature modification of osmotically induced vasopressin secretion and thirst in humans. American Journal Of Physiology 1995, 269: r874-r880. PMID: 7485606, DOI: 10.1152/ajpregu.1995.269.4.r874.Peer-Reviewed Original Research