2024
Blood pressure responses to handgrip exercise but not apnea or mental stress are enhanced in women with a recent history of preeclampsia
Berbrier D, Adler T, Leone C, Paidas M, Stachenfeld N, Usselman C. Blood pressure responses to handgrip exercise but not apnea or mental stress are enhanced in women with a recent history of preeclampsia. AJP Heart And Circulatory Physiology 2024, 327: h140-h154. PMID: 38700469, DOI: 10.1152/ajpheart.00020.2024.Peer-Reviewed Original ResearchMuscle sympathetic nerve activitySystolic blood pressureResponse to acute stimuliIsometric handgrip exercise protocolMental stressHandgrip exercise protocolCardiovascular diseaseExercise-induced increaseEffective prevention strategiesAcute stimuliExercise protocolHistory of preeclampsiaBlood pressureIntegrated muscle sympathetic nerve activityElevated long-term riskElevated cardiovascular riskLong-term riskEnd-expiratory apneaSympathetic nerve activityPrevention strategiesHandgrip exerciseBlood pressure responseRisk factorsExaggerated pressorHealthy pregnancy
2014
Hormonal Changes During Menopause and the Impact on Fluid Regulation
Stachenfeld NS. Hormonal Changes During Menopause and the Impact on Fluid Regulation. Reproductive Sciences 2014, 21: 555-561. PMID: 24492487, PMCID: PMC3984489, DOI: 10.1177/1933719113518992.Peer-Reviewed Original ResearchConceptsHormone therapySodium retentionMenopausal womenFluid regulationCardiovascular functionAldosterone-mediated sodium retentionRisk of hyponatremiaBlood pressure responseFemale reproductive hormonesFluid-regulating hormonesBody fluid volumeRisk of dehydrationBody fluid regulationEstrogen therapyHypervolemic hyponatremiaCardiovascular riskEstradiol effectsSodium loadProgesterone exposureMineralocorticoid receptorProgestogen exposureReproductive hormonesReproductive surgeryHormonal changesDistal tubules
2011
Estrogen enhances baroreflex sensitivity in women with low orthostatic tolerance
Wenner M, Taylor H, Haddadin A, Stachenfeld N. Estrogen enhances baroreflex sensitivity in women with low orthostatic tolerance. The FASEB Journal 2011, 25: 647.3-647.3. DOI: 10.1096/fasebj.25.1_supplement.647.3.Peer-Reviewed Original ResearchCardiovagal baroreflex sensitivityBaroreflex sensitivityLow orthostatic toleranceOrthostatic toleranceCumulative stress indexPlasma E2Endogenous sex hormone productionGnRH antagonist administrationBlood pressure responseSex hormone productionLower body negative pressure testBaseline BPAntagonist administrationBaroreflex functionSystolic BPE2 administrationOrthostatic intoleranceE2 conditionsBolus infusionHT womenNegative pressure testProgesterone concentrationsSodium nitroprussideGnRHaDay 5
1991
Gender differences in the systolic blood pressure response to exercise
Gleim G, Stachenfeld N, Coplan N, Nicholas J. Gender differences in the systolic blood pressure response to exercise. American Heart Journal 1991, 121: 524-530. PMID: 1990758, DOI: 10.1016/0002-8703(91)90721-s.Peer-Reviewed Original ResearchConceptsSystolic blood pressure responseBlood pressure responseSystolic blood pressureBody surface areaLean body massBlood pressurePressure responseBody weightHigher systolic blood pressureSympathetic nervous system responsesNormal cardiac responseUrinary norepinephrine excretionPeak heart rateNervous system responsesGender differencesNorepinephrine excretionBody massExercise modalitiesDynamic exerciseHeart rateCardiac responseInfluence of genderMenModalitiesResponse