2015
Chinese herbal medicine for miscarriage affects decidual micro-environment and fetal growth
Piao L, Chen C, Yeh C, Basar M, Masch R, Cheng Y, Lockwood CJ, Schatz F, Huang SJ. Chinese herbal medicine for miscarriage affects decidual micro-environment and fetal growth. Placenta 2015, 36: 559-566. PMID: 25771406, PMCID: PMC4395550, DOI: 10.1016/j.placenta.2015.02.006.Peer-Reviewed Original ResearchConceptsFirst trimester decidual cellsIL-1βDecidual cellsPlacental weightFetal growthFood intakeResorption rateFetal resorption rateMaternal food intakeM-CSFC motif ligand 2Intrauterine growth restrictionIGF-IR expressionInducible protein-10Anti-CD163 antibodyQRT-PCRChinese herbal formulaIL-8 productionChinese herbal medicineG-CSF expressionEndothelial cell angiogenesisPlacental IGFDecidual macrophagesFetal weightCytokine expression
2014
Interferon-γ Protects First-Trimester Decidual Cells against Aberrant Matrix Metalloproteinases 1, 3, and 9 Expression in Preeclampsia
Lockwood CJ, Basar M, Kayisli UA, Guzeloglu-Kayisli O, Murk W, Wang J, De Paz N, Shapiro JP, Masch RJ, Semerci N, Huang SJ, Schatz F. Interferon-γ Protects First-Trimester Decidual Cells against Aberrant Matrix Metalloproteinases 1, 3, and 9 Expression in Preeclampsia. American Journal Of Pathology 2014, 184: 2549-2559. PMID: 25065683, PMCID: PMC4188280, DOI: 10.1016/j.ajpath.2014.05.025.Peer-Reviewed Original ResearchMeSH KeywordsBlotting, WesternDeciduaEnzyme-Linked Immunosorbent AssayFemaleHumansImmunohistochemistryInterferon-gammaKiller Cells, NaturalMacrophagesMatrix Metalloproteinase 1Matrix Metalloproteinase 3Matrix Metalloproteinase 9Matrix Metalloproteinases, SecretedPre-EclampsiaPregnancyPregnancy Trimester, FirstReal-Time Polymerase Chain ReactionConceptsMitogen-activated protein kinaseP38 mitogen-activated protein kinaseMitogen-activated protein kinase phosphorylationP38 mitogen-activated protein kinase phosphorylationExtracellular matrix proteinsProtein kinase phosphorylationHuman first trimester decidual cellsProtein kinaseReal-time quantitative RT-PCREVT invasionKinase phosphorylationQuantitative RT-PCRMatrix proteinsProteolytic cascadeDecidual cellsIntegrin receptorsExtravillous trophoblastsHuman extravillous trophoblastsIncomplete spiral arteryMMP-9Protein levelsProtein expressionMMP-1MMP-2Fibrillar collagen
2010
The Implication of Aberrant GM-CSF Expression in Decidual Cells in the Pathogenesis of Preeclampsia
Huang SJ, Zenclussen AC, Chen CP, Basar M, Yang H, Arcuri F, Li M, Kocamaz E, Buchwalder L, Rahman M, Kayisli U, Schatz F, Toti P, Lockwood CJ. The Implication of Aberrant GM-CSF Expression in Decidual Cells in the Pathogenesis of Preeclampsia. American Journal Of Pathology 2010, 177: 2472-2482. PMID: 20829438, PMCID: PMC2966804, DOI: 10.2353/ajpath.2010.091247.Peer-Reviewed Original ResearchConceptsGranulocyte-macrophage colony-stimulating factorColony-stimulating factorPathogenesis of preeclampsiaDendritic cellsDecidual cellsFirst trimester human decidual cellsGranulocyte-macrophage colony-stimulating factor (GM-CSF) expressionGenesis of preeclampsiaSystemic inflammatory stateInterleukin-1 βTumor necrosis factorHuman decidual cellsColony-stimulating factor expressionFactor expression levelsColony-stimulating factor productionGM-CSF expressionGranulocyte-macrophage colony-stimulating factor productionPreeclamptic deciduaShallow placentationInflammatory stateHuman deciduaNecrosis factorMurine modelPreeclampsiaMouse model