Contribution of Coagulases towards Staphylococcus aureus Disease and Protective Immunity
Cheng AG, McAdow M, Kim HK, Bae T, Missiakas DM, Schneewind O. Contribution of Coagulases towards Staphylococcus aureus Disease and Protective Immunity. PLOS Pathogens 2010, 6: e1001036. PMID: 20700445, PMCID: PMC2916881, DOI: 10.1371/journal.ppat.1001036.Peer-Reviewed Original ResearchMeSH KeywordsAbscessAnimalsAntibodiesBacterial ProteinsCoagulaseEnzyme-Linked Immunosorbent AssayHumansImmunohistochemistryMiceMice, Inbred BALB CStaphylococcal InfectionsStaphylococcus aureusSurface Plasmon ResonanceConceptsSpecific antibodiesFormation of abscessesHost immune cellsStaphylococcus aureus diseaseVon Willebrand factorProtective immunityAbscess formationStaphylococcal vaccineImmune cellsLethal bacteremiaNon-proteolytic activationAbscessCleavage of fibrinogenProtective antigenWillebrand factorS. aureusStaphylococcus aureusPseudocapsuleHistochemical stainingAntibodiesProthrombinHost tissuesCoagulaseVWbpAureus