2012
Staphylococcus aureus Secretes Coagulase and von Willebrand Factor Binding Protein to Modify the Coagulation Cascade and Establish Host Infections
McAdow M, Missiakas DM, Schneewind O. Staphylococcus aureus Secretes Coagulase and von Willebrand Factor Binding Protein to Modify the Coagulation Cascade and Establish Host Infections. Journal Of Innate Immunity 2012, 4: 141-148. PMID: 22222316, PMCID: PMC3388267, DOI: 10.1159/000333447.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsFormation of abscessesDrug-resistant S. aureusHost immune cellsHospital-acquired infectionsFactor binding proteinInnate defense mechanismsVon Willebrand factorThromboembolic lesionsClotting of plasmaPreclinical evidenceLethal sepsisImmune cellsStaphylococcal infectionsDisease pathogenesisCoagulation productsClinical isolatesCurrent epidemicKey innate defence mechanismCoagulation cascadeStaphylococcal productsInfectionWillebrand factorOpsonophagocytic clearanceHost infectionFibrin meshwork
2011
Preventing Staphylococcus aureus Sepsis through the Inhibition of Its Agglutination in Blood
McAdow M, Kim HK, DeDent AC, Hendrickx AP, Schneewind O, Missiakas DM. Preventing Staphylococcus aureus Sepsis through the Inhibition of Its Agglutination in Blood. PLOS Pathogens 2011, 7: e1002307. PMID: 22028651, PMCID: PMC3197598, DOI: 10.1371/journal.ppat.1002307.Peer-Reviewed Original ResearchMeSH KeywordsAgglutinationAnimalsAntibodies, NeutralizingAntithrombinsBacterial ProteinsCarrier ProteinsCoagulantsCoagulaseDisease Models, AnimalHeartHost-Pathogen InteractionsHumansImmunization, PassiveLongevityMiceMice, Inbred BALB CMyocardiumProtein BindingSepsisStaphylococcal InfectionsStaphylococcus aureusVon Willebrand FactorConceptsAureus sepsisLethal outcomeDabigatran etexilate treatmentS. aureus sepsisDirect thrombin inhibitorStaphylococcus aureus sepsisStaphylococcus aureus infectionVon Willebrand factorThromboembolic lesionsStaphylococcal sepsisAureus infectionFrequent causeMouse modelSepsisDisease pathogenesisHigh mortalityThrombin inhibitorsBacterial factorsSpecific interventionsHeart tissueWillebrand factorFibrin cableVirulence genesAgglutinationDisease