2023
A Glucocorticoid-Sensitive Hippocampal Gene Network Moderates the Impact of Early-Life Adversity on Mental Health Outcomes
Arcego D, Buschdorf J, O'Toole N, Wang Z, Barth B, Pokhvisneva I, Rayan N, Patel S, de Mendonça Filho E, Lee P, Tan J, Koh M, Sim C, Parent C, de Lima R, Clappison A, O'Donnell K, Dalmaz C, Arloth J, Provençal N, Binder E, Diorio J, Silveira P, Meaney M. A Glucocorticoid-Sensitive Hippocampal Gene Network Moderates the Impact of Early-Life Adversity on Mental Health Outcomes. Biological Psychiatry 2023, 95: 48-61. PMID: 37406925, DOI: 10.1016/j.biopsych.2023.06.028.Peer-Reviewed Original ResearchConceptsHippocampal dentate gyrusDentate gyrusPsychiatric disordersHuman hippocampal cellsBrain gray matter densityEarly adversitySingle nucleotide polymorphismsMultiple psychiatric conditionsEarly life adversityGray matter densityAdult female macaquesMental health outcomesTranscriptional activityGlucocorticoid exposureNucleotide polymorphismsLater psychosisStress mediatorsHippocampal cellsPsychotic disordersAnimal modelsHealth outcomesPsychiatric conditionsSignificant associationFemale macaquesMental health
2015
Symptoms of major depressive disorder subsequent to child maltreatment: Examining change across multiple levels of analysis to identify transdiagnostic risk pathways
Shenk CE, Griffin AM, O'Donnell KJ. Symptoms of major depressive disorder subsequent to child maltreatment: Examining change across multiple levels of analysis to identify transdiagnostic risk pathways. Development And Psychopathology 2015, 27: 1503-1514. PMID: 26535940, PMCID: PMC4774890, DOI: 10.1017/s0954579415000905.Peer-Reviewed Original ResearchConceptsMajor depressive disorderMDD symptomsDepressive disorderRisk pathwaysChild maltreatmentPrevalent psychiatric conditionChild maltreatment populationSubstantiated child maltreatmentPsychiatric conditionsSymptomsClinical interventionsSaliva samplesLaboratory stressorDirect targetingFemale adolescentsCertain childrenChildrenEmotion regulationDisordersComparison conditionSignificant indirect effectCurrent studyMaltreatmentPathwayEmotion dysregulation