2023
Maternal prenatal depression is associated with dysregulation over the first five years of life moderated by child polygenic risk for comorbid psychiatric problems
Babineau V, Jolicoeur‐Martineau A, Szekely E, Green C, Sassi R, Gaudreau H, Levitan R, Lydon J, Steiner M, O'Donnell K, Kennedy J, Burack J, Wazana A. Maternal prenatal depression is associated with dysregulation over the first five years of life moderated by child polygenic risk for comorbid psychiatric problems. Developmental Psychobiology 2023, 65: e22395. PMID: 37338256, DOI: 10.1002/dev.22395.Peer-Reviewed Original ResearchConceptsMaternal prenatal depressionPolygenic risk scoresPrenatal depressionPsychiatric problemsChild psychiatric problemsComorbid psychiatric problemsChildhood psychiatric problemsMajor depressive disorderHigher dysregulationYears of lifeAttention deficit hyperactivity disorderDeficit hyperactivity disorderWeeks' gestationPsychiatric comorbidityPrenatal cohortDepressive disorderPostnatal depressionRisk scorePrenatal stressDepression symptomsMaternal educationGreater riskHyperactivity disorderDysregulationPolygenic risk
2016
Maternal prenatal depression is associated with decreased placental expression of the imprinted gene PEG3
Janssen AB, Capron LE, O'Donnell K, Tunster SJ, Ramchandani PG, Heazell AE, Glover V, John RM. Maternal prenatal depression is associated with decreased placental expression of the imprinted gene PEG3. Psychological Medicine 2016, 46: 2999-3011. PMID: 27523184, PMCID: PMC5080674, DOI: 10.1017/s0033291716001598.Peer-Reviewed Original ResearchConceptsMaternal prenatal depressionFetal growth restrictionPrenatal depressionPlacental expressionGrowth restrictionMedical notesDepression scoresFurther independent cohortImpaired placental functionPlacental lactogen productionAdverse neurodevelopmental outcomesDiagnosis of depressionMaternal depression scoresPoor offspring outcomesMaternal prenatal stressCyclin-dependent kinase inhibitor 1CPlacental gene expressionHigher depression scoresAberrant placental expressionNeurodevelopmental outcomesCohort participantsFetal growthPleckstrin homology-like domain familyPlacental functionMaternal depression
2014
The persisting effect of maternal mood in pregnancy on childhood psychopathology
O'Donnell KJ, Glover V, Barker ED, O'Connor TG. The persisting effect of maternal mood in pregnancy on childhood psychopathology. Development And Psychopathology 2014, 26: 393-403. PMID: 24621564, DOI: 10.1017/s0954579414000029.Peer-Reviewed Original ResearchConceptsPrenatal anxietyMaternal moodPostnatal maternal moodLongitudinal studyMaternal prenatal anxietyLarge community samplePrenatal maternal moodOccasions of measurementPsychiatric symptomsChild mental disordersChild psychiatric symptomsEmotional problemsCommunity sampleAvon Longitudinal StudyEmotional symptomsChildhood psychopathologyPostnatal moodAge 4MoodAnxietyPersisting effectProgramming hypothesisMental disordersPrenatal depressionMajor models