2023
Maternal sensitivity and child internalizing and externalizing behavior: a mediating role for glucocorticoid receptor gene (NR3C1) methylation?
Creasey N, Beijers R, O'Donnell K, de Weerth C, Tollenaar M. Maternal sensitivity and child internalizing and externalizing behavior: a mediating role for glucocorticoid receptor gene (NR3C1) methylation? Development And Psychopathology 2023, 36: 967-978. PMID: 36896668, DOI: 10.1017/s0954579423000226.Peer-Reviewed Original ResearchAge 5 weeksChild mental healthMaternal sensitivityMental healthGlucocorticoid receptor gene methylationAge 6 yearsChildren's internalizingMethylation levelsMother-infant interactionDNA methylation levelsAnimal modelsEarly infancyStress regulatory systemsExternalizing behaviorsEarly caregiving environmentGene DNA methylationAge 6Longitudinal studyLower DNA methylation levelsResponsive caregivingSame childrenCommunity sampleCaregiving environmentGene methylationDNA methylationInvestigating the effects of maltreatment and acute stress on the concordance of blood and DNA methylation methods of estimating immune cell proportions
Apsley A, Etzel L, Hastings W, Heim C, Noll J, O’Donnell K, Schreier H, Shenk C, Ye Q, Shalev I. Investigating the effects of maltreatment and acute stress on the concordance of blood and DNA methylation methods of estimating immune cell proportions. Clinical Epigenetics 2023, 15: 33. PMID: 36855187, PMCID: PMC9976543, DOI: 10.1186/s13148-023-01437-5.Peer-Reviewed Original ResearchConceptsComplete blood countImmune cell proportionsAcute psychosocial stressCell proportionPsychosocial stressPsychosocial stress altersImmune cell subtypesAcute laboratory stressorEarly life adversityStress-exposed individualsChild maltreatmentPediatric cohortBlood countCell subtypesAcute stressStress-induced changesPathophysiological statesLife adversityCritical covariatesLaboratory stressorYoung adultsEffects of maltreatmentDNAm alterationsClinical populationsDNA methylation
2022
Unified epigenomic, transcriptomic, proteomic, and metabolomic taxonomy of Alzheimer’s disease progression and heterogeneity
Iturria-Medina Y, Adewale Q, Khan A, Ducharme S, Rosa-Neto P, O'Donnell K, Petyuk V, Gauthier S, De Jager P, Breitner J, Bennett D. Unified epigenomic, transcriptomic, proteomic, and metabolomic taxonomy of Alzheimer’s disease progression and heterogeneity. Science Advances 2022, 8: eabo6764. PMID: 36399579, PMCID: PMC9674284, DOI: 10.1126/sciadv.abo6764.Peer-Reviewed Original ResearchConceptsMolecular taxonomy of ADAlzheimer's diseaseMolecular dataAlzheimer's disease progressionGenetic variationDNA methylationPattern of alterationsAD dementia progressionAD variantsCell typesPostmortem brainsHeterogeneous disorderBiological domainSpatial pattern of alterationAlzheimerClinical heterogeneityTaxonomyAD subtypesMetabolomic profilesSpatial patternsMolecular indicesAdvanced machine learning analysisDisease progressionRNADNA
2019
Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns
Czamara D, Eraslan G, Page CM, Lahti J, Lahti-Pulkkinen M, Hämäläinen E, Kajantie E, Laivuori H, Villa PM, Reynolds RM, Nystad W, Håberg SE, London SJ, O’Donnell K, Garg E, Meaney MJ, Entringer S, Wadhwa PD, Buss C, Jones MJ, Lin DTS, MacIsaac JL, Kobor MS, Koen N, Zar HJ, Koenen KC, Dalvie S, Stein DJ, Kondofersky I, Müller NS, Theis FJ, Räikkönen K, Binder E. Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns. Nature Communications 2019, 10: 2548. PMID: 31186427, PMCID: PMC6559955, DOI: 10.1038/s41467-019-10461-0.Peer-Reviewed Original ResearchConceptsDNA methylationEnvironmental factorsCellular functionsEpigenetic processesCord blood DNA methylationBlood DNA methylationMethylationGenetic variantsGenetic contributionIntegrated analysisPrenatal environmental factorsComplex disorderGenetic influencesGxE modelsGenotypesGWASRelative contributionGxEIndependent cohortCpGDisease riskEnrichmentVariantsDynamic DNA methylation changes in the maternal oxytocin gene locus (OXT) during pregnancy predict postpartum maternal intrusiveness
Toepfer P, O'Donnell KJ, Entringer S, Garg E, Heim CM, Lin DTS, MacIsaac JL, Kobor MS, Meaney MJ, Provençal N, Binder EB, Wadhwa PD, Buss C. Dynamic DNA methylation changes in the maternal oxytocin gene locus (OXT) during pregnancy predict postpartum maternal intrusiveness. Psychoneuroendocrinology 2019, 103: 156-162. PMID: 30690225, PMCID: PMC6554513, DOI: 10.1016/j.psyneuen.2019.01.013.Peer-Reviewed Original ResearchConceptsLate pregnancyMaternal behaviorMonths postpartumEarly postnatal developmentNovel potential biomarkersRace/ethnicityPregnancy inducesPeripheral bloodPregnancyMother-child dyadsPostnatal maternal behaviourPostnatal developmentPotential biomarkersSteroid hormonesDNA methylationSocioeconomic statusWhole bloodPromoter DNA methylationMother-child interactionPostpartumBloodDNA methylation changesOxytocinDNAm trajectoriesMaternal intrusiveness
2018
The early care environment and DNA methylome variation in childhood
Garg E, Chen L, Nguyen TTT, Pokhvisneva I, Chen LM, Unternaehrer E, MacIsaac JL, McEwen LM, Mah SM, Gaudreau H, Levitan R, Moss E, Sokolowski MB, Kennedy JL, Steiner MS, Meaney MJ, Holbrook JD, Silveira PP, Karnani N, Kobor MS, O'Donnell KJ. The early care environment and DNA methylome variation in childhood. Development And Psychopathology 2018, 30: 891-903. PMID: 30068421, DOI: 10.1017/s0954579418000627.Peer-Reviewed Original ResearchConceptsGenome-wide DNA methylationDNA methylationGenetic variationGenetic dataEarly care environmentsMethylome variationInfant attachment styleInfant attachmentEpigenetic modificationsAttachment styleBuccal epithelial samplesMethylationMolecular signaturesPrenatal adversityGenetic contributionInfant developmentChild genetic variationInfant cognitive developmentDisorganized attachment styleLater mental health problemsNegative effectsEarly intervention programsChild mental healthMental health problemsCognitive developmentEpigenetics and Early Life Adversity: Current Evidence and Considerations for Epigenetic Studies in the Context of Child Maltreatment
Bouvette-Turcot A, Meaney M, O’Donnell K. Epigenetics and Early Life Adversity: Current Evidence and Considerations for Epigenetic Studies in the Context of Child Maltreatment. Child Maltreatment Solutions Network 2018, 89-119. DOI: 10.1007/978-3-319-72589-5_7.Peer-Reviewed Original ResearchMental healthEarly adversityEarly life adversityLater mental healthEarly childhood adversityLater riskClinical studiesPreclinical modelsCurrent evidenceMental disordersChildhood adversityLife adversityPutative mechanismsNeural developmentDNA methylationEarly social environmentChild maltreatmentEarly environmentHealthAdversityEpigenetic mechanismsDNA methylome variation in a perinatal nurse-visitation program that reduces child maltreatment: a 27-year follow-up
O’Donnell K, Chen L, MacIsaac JL, McEwen LM, Nguyen T, Beckmann K, Zhu Y, Chen LM, Brooks-Gunn J, Goldman D, Grigorenko EL, Leckman JF, Diorio J, Karnani N, Olds DL, Holbrook JD, Kobor MS, Meaney MJ. DNA methylome variation in a perinatal nurse-visitation program that reduces child maltreatment: a 27-year follow-up. Translational Psychiatry 2018, 8: 15. PMID: 29317599, PMCID: PMC5802588, DOI: 10.1038/s41398-017-0063-9.Peer-Reviewed Original ResearchConceptsNurse-Family PartnershipIntervention programsProspective longitudinal studyYears of ageMajor psychiatric disordersAge 27 yearsChild maltreatmentPsychosocial intervention programEarly intervention programsLifestyle factorsIntervention groupBlood samplesPsychiatric disordersAdult offspringDiagnostic InterviewChildhood adversityNFP programInterindividual variationLongitudinal studyComponent scoresSustained impactAbuse/neglectDNA methylationFamily partnershipsDNA methylome