2018
Maternal antenatal mood and child development: an exploratory study of treatment effects on child outcomes up to 5 years
Milgrom J, Holt CJ, Bleker LS, Holt C, Ross J, Ericksen J, Glover V, O’Donnell K, de Rooij SR, Gemmill AW. Maternal antenatal mood and child development: an exploratory study of treatment effects on child outcomes up to 5 years. Journal Of Developmental Origins Of Health And Disease 2018, 10: 221-231. PMID: 30303063, DOI: 10.1017/s2040174418000739.Peer-Reviewed Original ResearchMeSH KeywordsAnxietyBehavior Rating ScaleChild BehaviorChild DevelopmentChild, PreschoolCognitive Behavioral TherapyDepressionFemaleFollow-Up StudiesHumansIntelligence TestsLongitudinal StudiesMaleMothersParent-Child RelationsPregnancyPregnancy ComplicationsPrenatal Exposure Delayed EffectsRandomized Controlled Trials as TopicSeverity of Illness IndexTreatment OutcomeConceptsChild Behavior ChecklistParenting Stress IndexNeurodevelopmental outcomesChild developmentHigher CBCLIntervention effectsAntenatal depression treatmentMaternal antenatal depressionAdverse neurodevelopmental outcomesInfant neurodevelopmental outcomesAge 2Age 5Cognitive behavioral therapyWPPSI-III scoresNon-significant trendPSI total scoreAntenatal moodAntenatal depressionRoutine careDepression treatmentOriginal cohortTreatment allocationIntervention groupLong-term effectsEffective treatment
2016
Maternal prenatal depression is associated with decreased placental expression of the imprinted gene PEG3
Janssen AB, Capron LE, O'Donnell K, Tunster SJ, Ramchandani PG, Heazell AE, Glover V, John RM. Maternal prenatal depression is associated with decreased placental expression of the imprinted gene PEG3. Psychological Medicine 2016, 46: 2999-3011. PMID: 27523184, PMCID: PMC5080674, DOI: 10.1017/s0033291716001598.Peer-Reviewed Original ResearchConceptsMaternal prenatal depressionFetal growth restrictionPrenatal depressionPlacental expressionGrowth restrictionMedical notesDepression scoresFurther independent cohortImpaired placental functionPlacental lactogen productionAdverse neurodevelopmental outcomesDiagnosis of depressionMaternal depression scoresPoor offspring outcomesMaternal prenatal stressCyclin-dependent kinase inhibitor 1CPlacental gene expressionHigher depression scoresAberrant placental expressionNeurodevelopmental outcomesCohort participantsFetal growthPleckstrin homology-like domain familyPlacental functionMaternal depression
2011
Maternal prenatal anxiety and downregulation of placental 11β-HSD2
O’Donnell K, Jensen A, Freeman L, Khalife N, O’Connor T, Glover V. Maternal prenatal anxiety and downregulation of placental 11β-HSD2. Psychoneuroendocrinology 2011, 37: 818-826. PMID: 22001010, DOI: 10.1016/j.psyneuen.2011.09.014.Peer-Reviewed Original ResearchConceptsPlacental 11β-HSD2Maternal prenatal anxietyMaternal anxietyPlacental 11β-hydroxysteroid dehydrogenase type 2Prenatal stressPrenatal anxietyDepression self-rating scalePrenatal maternal moodAdverse neurodevelopmental outcomesDehydrogenase type 2Subset of casesElective caesareanNeurodevelopmental outcomesFetal exposureMaternal moodMaternal cortisolFetal programmingState anxietyAnimal studiesSelf-rating scaleFemale fetusesType 2MRNA expressionDownregulationCortisol
2009
Prenatal Stress and Neurodevelopment of the Child: Focus on the HPA Axis and Role of the Placenta
O’Donnell K, O’Connor T, Glover V. Prenatal Stress and Neurodevelopment of the Child: Focus on the HPA Axis and Role of the Placenta. Developmental Neuroscience 2009, 31: 285-292. PMID: 19546565, DOI: 10.1159/000216539.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsHPA axisMaternal stressPrenatal stressAnimal studiesMaternal HPA axisAdverse neurodevelopmental outcomesRecent human studiesPartner relationship problemsNeurodevelopmental outcomesFetal exposureFetal neurodevelopmentMaternal cortisolHuman studiesPrenatal stressorsPlacentaBehavioral problemsMaternal environmentCortisolNeurodevelopmentChildrenRelationship problemsAnxietySimilar mechanismPregnancyMixed results