2021
Cortisol trajectories measured prospectively across thirty years of female development following exposure to childhood sexual abuse: Moderation by epigenetic age acceleration at midlife
Shenk CE, Felt JM, Ram N, O'Donnell KJ, Sliwinski MJ, Pokhvisneva I, Benson L, Meaney MJ, Putnam FW, Noll JG. Cortisol trajectories measured prospectively across thirty years of female development following exposure to childhood sexual abuse: Moderation by epigenetic age acceleration at midlife. Psychoneuroendocrinology 2021, 136: 105606. PMID: 34896740, PMCID: PMC8724404, DOI: 10.1016/j.psyneuen.2021.105606.Peer-Reviewed Original ResearchConceptsEarly life adversityEpigenetic age accelerationChildhood sexual abuseCortisol trajectoriesLife adversityAge accelerationCortisol concentrationsBiological embedding modelProspective cohort studyPeak cortisol levelsHPA axis activitySubstantiated childhood sexual abuseEarly ageCohort studyAdulthood healthHPA axisAdrenal axisCortisol secretionCsA exposureCortisol levelsPotential indicationsSexual abuseMultiple biological systemsSubsequent occasionsBiological embedding
2018
Prenatal maternal stress, fetal programming, and mechanisms underlying later psychopathology—A global perspective
Glover V, O'Donnell KJ, O'Connor TG, Fisher J. Prenatal maternal stress, fetal programming, and mechanisms underlying later psychopathology—A global perspective. Development And Psychopathology 2018, 30: 843-854. PMID: 30068411, DOI: 10.1017/s095457941800038x.BooksMeSH KeywordsAnxiety DisordersBrainChildCross-Cultural ComparisonDepressive DisorderDeveloping CountriesFemaleFetal DevelopmentHumansHypothalamo-Hypophyseal SystemInfantMental DisordersPituitary-Adrenal SystemPregnancyPrenatal Exposure Delayed EffectsPsychopathologyPsychosocial DeprivationRisk FactorsSocial EnvironmentStress, PsychologicalConceptsPrenatal stressLater psychopathologyPregnancy-specific anxietyPrenatal maternal stressPrenatal stress altersAdrenal axisChild neurodevelopmentHigh-income countriesFetal programmingInfant deathMaternal stressGene-environment interactionsNutritional deficienciesMothers' stressDifferent ethnic groupsStress altersPsychopathologyBiological differencesEthnic groupsInterpersonal violenceAnxietyCaucasian samplesHigh levelsPregnancyCytokines