The March 2025 issue of the Yale Journal of Biology and Medicine (YJBM), on kinase signaling, has been published on PubMed Central (PMC). This focus issue features articles on the kinase enzymes that modify target proteins which have a far-reaching impact on cells, tissues, and their roles in disease.

Highlights of the issue include an original contribution by Hakime, Nagano, and Brassesco (University of São Paulo, São Paulo, Brazil) on Rho-associated protein kinases (ROCK 1 and ROCK2) in pediatric medulloblastoma. They report possible evidence that they may act as tumor suppressors.

Next, we present another original contribution by Bagheri et al. (Shiraz University of Medical Sciences, Shiraz, Iran) on the impact of activating transcription factor 3 (ATF3) overexpression on proteins that have roles in cervical cancer.

Lastly, a review by Cheung and Wu (University of Massachusetts, Amherst, MA) discusses kinase signaling in plants, specifically species in the genus Arabidopsis (rockcress), and the receptor kinase FERONIA.

Deputy Editors of this issue: Rahul Gupta (Department of Molecular, Cellular, and Developmental Biology, Yale University) and Ingrid Heumann (Department of Genetics, Yale University). Editors-in-Chief: Charlotte Godfrey (Molecular Biophysics & Biochemistry, Yale University) and Samantha Seneviratne (Yale School of Public Health).