Gamma Knife Stereotactic Radiosurgery

The Yale New Haven Gamma Knife is the only radiosurgery unit in Connecticut dedicated to the treatment of head and neck conditions. 

Staffed by a team of specialists with cumulatively greater than 30 years of radiosurgery experience, treatment at our center results in predictable and nationally recognized outcomes. While the majority of our patients are adults, the Yale facility has also treated many pediatric patients.

The Principle

Stereotactic radiosurgery is the delivery of a high dose of highly focused radiation in a single session to treat specifically chosen intracranial targets. At Yale, this treatment is delivered using a unit called the Gamma Knife -Originally designed by Dr Lars Leksell in Sweden, this machine contains 192 cobalt-60 sources arranged in a hemispherical array and housed in a heavily shielded unit. Using this unit, radiation is precisely focused to deliver the high dose of radiation only to the designated target while sparing the surrounding tissues. Complex shaped lesions can be treated by combining varying-sized collimators with selected beam blocking and dose weighting using very sophisticated computer planning software. This ensures that each patient's lesion(s) receive a tightly conformal "tailored" treatment plan.

Experience and Safety

The Yale New Haven Hospital Gamma Knife Center is the radiosurgery center with by far the most treating experience in Connecticut. The Gamma Knife remains the gold standard machine for radiosurgical treatment of brain lesions because unlike linear accelerator (LINAC) based systems, including the Cyberknife, the Gamma Knife has few moving parts thereby eliminating many sources of inaccuracy and unreliability. The Gamma Knife is a machine dedicated to treating the head and is only available in Connecticut here at the Yale New Haven Hospital. Almost 3000 patients have been treated at the center since 1998 for a variety of conditions.


The most common indications for use of Gamma Knife include:

  1. Brain Metastases – most commonly from lung cancer, melanoma, breast cancer, colon cancer, renal cell cancer and gynecological and genito-urinary cancers,
  2. Benign Brain Tumors – such as meningiomas, vestibular schwannomas, and pituitary adenomas,
  3. Arteriovenous Malformations, and
  4. Trigeminal Neuralgia 

The Center also has experience treating other conditions such as:

  1. Intraocular Melanoma
  2. Head and Neck cancers such as nasopharyngeal carcinoma
  3. Recurrent Malignant primary Brain Tumors
  4. Glomus Jugulare tumors
  5. Essential Tremor (GK thalamotomy)

Many of the conditions that are treatable by radiosurgery are also treated by surgery. Gamma Knife gives the neurosurgeon the ability to effectively treat these conditions with similar surgical precision without many of the risks and discomfort of open surgery and general anesthesia. Gamma Knife radiosurgery requires no incisions, is performed under local anesthesia and is performed with minimal discomfort. Radiosurgery has therefore been particularly useful in patients with co-existent illnesses where conventional surgery would pose an unacceptable risk. Finally, as a one-day outpatient procedure, the cost effectiveness of Gamma Knife treatment often exceeds that of open surgery. Hospitalization is only required in exceptional circumstances and most patients are able to return to their normal activities within 24 hours of the procedure.

Candidates for Gamma Knife are selected for treatment only after a thorough review of all prior medical records and imaging studies by our specialist teams of neurosurgeons and radiation oncologists.

Gamma Knife Surgeons

Bio Profile

Veronica Chiang, MD, FAANS


Professor of Neurosurgery

Associate Vice Chair of Academic Affairs

Director, Stereotactic Radiosurgery

Director, Gamma Knife Center, YNHH

Director, Stereotactic Radiosurgery Fellowship

Bio Profile

Jason Gerrard, MD, PhD, FAANS

Assistant Professor of Neurosurgery and of Neuroscience

Chief, Functional Neurosurgery

Chief, Trauma Neurosurgery, YNHH

Bio Profile

Murat Gunel, MD, FACS, FAHA, FAANS

Nixdorff-German Professor of Neurosurgery and Professor of Genetics and of Neuroscience

Chair, Department of Neurosurgery

Chief, Neurosurgery, Yale New Haven Health System

Chair, Perioperative Executive Leadership Committee

Director, Residency Program

Member, National Academy of Medicine

Co-Director, Yale Program on Neurogenetics

Bio Profile

Jennifer Moliterno, MD, FAANS

Assistant Professor of Neurosurgery

Clinical Program Leader, Brain Tumor Program

Brain Tumor Surgery

Associate Residency Program Director

Bio Profile

Sacit Bulent Omay, MD

Assistant Professor of Neurosurgery

Bio Profile

Joseph Piepmeier, MD, FAANS

Nixdorff-German Professor of Neurosurgery

Vice Chair of Academic Affairs, Neurosurgery

Chief, Brain Tumor Surgery


Many patients are directed to Yale by their neurosurgeons because their problem is unusual or extremely complicated. Patients may also refer themselves. Patients are seen quickly usually within two weeks of calling the department. All patients referred to Yale benefit from the multi-disciplinary team approach that is an essential feature of our practice. Our surgeons maintain a close working relationship with many area neurosurgeons and welcome referrals. Care is taken to ensure the referring physician is kept current on diagnostic findings and treatment recommendations.

Contact Information

Administrative Assistant:  

Joyce Galente: (203)785-2808

Yale New Haven Gamma Knife Center
Research Coordinator: 
Judith Hess: (203)737-6259

Patti Casper, RN