2015
Functional Synergy between Cholecystokinin Receptors CCKAR and CCKBR in Mammalian Brain Development
Nishimura S, Bilgüvar K, Ishigame K, Sestan N, Günel M, Louvi A. Functional Synergy between Cholecystokinin Receptors CCKAR and CCKBR in Mammalian Brain Development. PLOS ONE 2015, 10: e0124295. PMID: 25875176, PMCID: PMC4398320, DOI: 10.1371/journal.pone.0124295.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornBone Morphogenetic Protein 7Cell MovementChemokine CXCL12CholecystokininCorpus CallosumEmbryo, MammalianGene Expression ProfilingGene Expression Regulation, DevelopmentalHomozygoteHumansInterneuronsMiceMice, KnockoutMidline Thalamic NucleiMutationNeocortexNeuropilin-2Receptor, Cholecystokinin AReceptor, Cholecystokinin BReceptors, N-Methyl-D-AspartateSignal TransductionTranscriptomeConceptsCCK receptorsBrain developmentMammalian neocortical developmentCentral nervous systemCortical interneuron migrationHomozygous mutant miceMammalian brain developmentPeripheral organsReceptor lossCorpus callosumCortical developmentPostnatal brainAbundant neuropeptideNervous systemInterneuron migrationMutant miceEmbryonic neocortexNeocortical developmentReceptorsPeptide hormonesG proteinsCholecystokininReciprocal expressionCCKBRBrain
2008
Developmentally regulated and evolutionarily conserved expression of SLITRK1 in brain circuits implicated in Tourette syndrome
Stillman AA, Krsnik Ž, Sun J, Rašin M, State MW, šestan N, Louvi A. Developmentally regulated and evolutionarily conserved expression of SLITRK1 in brain circuits implicated in Tourette syndrome. The Journal Of Comparative Neurology 2008, 513: 21-37. PMID: 19105198, PMCID: PMC3292218, DOI: 10.1002/cne.21919.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainGene Expression Regulation, DevelopmentalHumansImmunohistochemistryMacaca mulattaMembrane ProteinsMiceNerve Tissue ProteinsNeural PathwaysNeuronsTourette SyndromeConceptsCorticostriatal-thalamocortical circuitsSingle-pass transmembrane proteinTourette syndromeEtiology of TSRare sequence variantsTransmembrane proteinSLITRK1Expression patternsCortical pyramidal neuronsCytoplasmic vesiclesDevelopmental expressionMember 1 geneSequence variantsAxonal repulsionSlit familyDendritic patterningDirect output pathwayCholinergic interneuronsPyramidal neuronsProjection neuronsStriatal expressionMotor ticsSomatodendritic compartmentDevelopmental neuropsychiatric disordersPatch compartment
2007
The derivatives of the Wnt3a lineage in the central nervous system
Louvi A, Yoshida M, Grove EA. The derivatives of the Wnt3a lineage in the central nervous system. The Journal Of Comparative Neurology 2007, 504: 550-569. PMID: 17701978, DOI: 10.1002/cne.21461.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBeta-GalactosidaseBody PatterningCell DifferentiationCell LineageCell MovementCentral Nervous SystemEmbryo, MammalianGene Expression Regulation, DevelopmentalIn Situ HybridizationMiceMice, TransgenicWnt ProteinsWnt3 ProteinWnt3A ProteinConceptsSpinal cordCervical spinal cordTrigeminal sensory systemRostral spinal cordCentral nervous systemCentral auditory systemDorsal midlineGenetic fate mappingSpecific functional networksAdult brainNervous systemDorsal halfBrain structuresCordLineage cellsAuditory systemMidbrainCell fate specificationVertebrate neural tubeNeural tubeFate mappingFunctional networksTransient gene expressionMidlineFate specification
2006
Notch signalling in vertebrate neural development
Louvi A, Artavanis-Tsakonas S. Notch signalling in vertebrate neural development. Nature Reviews Neuroscience 2006, 7: 93-102. PMID: 16429119, DOI: 10.1038/nrn1847.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsGene Expression Regulation, DevelopmentalModels, NeurologicalMorphogenesisNervous SystemNeuronsReceptors, NotchSignal TransductionVertebrates
2004
Presenilin 1 in migration and morphogenesis in the central nervous system
Louvi A, Sisodia SS, Grove EA. Presenilin 1 in migration and morphogenesis in the central nervous system. Development 2004, 131: 3093-3105. PMID: 15163631, DOI: 10.1242/dev.01191.Peer-Reviewed Original ResearchMeSH KeywordsAmyloid Precursor Protein SecretasesAnimalsAspartic Acid EndopeptidasesBrainBrain StemBromodeoxyuridineCell DifferentiationCell DivisionCell MovementCentral Nervous SystemCerebellumColoring AgentsCyclin-Dependent Kinase 5Cyclin-Dependent KinasesCytoskeletonDopamine AgentsEndopeptidasesGene Expression Regulation, DevelopmentalHomozygoteImmunohistochemistryIn Situ HybridizationLightMembrane ProteinsMiceMutationNeuronsPresenilin-1Time FactorsConceptsCentral nervous systemNervous systemPresenilin 1Premature neuronal differentiationCNS morphogenesisCerebral cortexCortical dysplasiaCortical laminationExternal granule layerPontine nucleiPresenilin-1 functionCerebellar granule cell precursorsFacial branchiomotor nucleusTangential migratory pathwayCaudal midbrainGranule cell precursorsNeuronal cellsBrain developmentNeuronal migrationTangential migrationBranchiomotor nucleiCell precursorsNeuronal differentiationGranule layerMidline fusion