Research Applies Machine Learning/AI to Predict Consciousness for Driving in People with Epilepsy
A new study published in September 2022 in Annals of Clinical and Translational Neurology may guide doctors in how to proceed when they observe SWDs on EEG, but are unclear of the patient’s neurological capacity for driving. Led by Principal Investigator Hal Blumenfeld, MD, PhD, researchers have harnessed the power of machine learning/artificial intelligence (AI) to address the shortcomings of traditional testing.
When Blood Transfusion Is Not an Option: Yale Neuro-ICU Successfully Administers Transfusion Replacement Therapy
The Yale New Haven neuro-ICU has successfully administered a transfusion replacement therapy, which benefits patients with aneurysmal subarachnoid hemorrhage (SAH), as well as those with severe anemia from blood loss and critical illness.
Yale School of Medicine starting trials on new epilepsy treatment that uses smart technology
About one-third of people diagnosed with epilepsy are not able to get relief from treatments currently available. Now, researchers at Yale University School of Medicine and two other locations are beginning trials on a new and innovative treatment that uses smart technology.Source: WTNH News 8
PATHS helps students from underrepresented backgrounds realize med school dreams
Nelson Perez Catalan discovered he was interested in pursuing science while working at a student job at the University of Oregon cleaning glass in the labs. He found himself drawn to research around the brain, and thought about pursuing an MD/PhD, but there was no medical school at his university and as a transplant from Chile, he says much of the U.S. college process was mystifying to him. Then he learned about PATHS, or Program to Advance Training in Health and Sciences at Yale School of Medicine.
$15M NIDA Grant Awarded to Serena Spudich, Mark Gerstein, and Yuval Kluger
Principal Investigators Serena Spudich, MD, MA (Neurology), Mark Gerstein, PhD (Molecular Biophysics and Biochemistry), and Yuval Kluger, PhD (Pathology) were recently awarded a $15 million grant from the National Institute on Drug Abuse (NIDA) to establish a Data Center to coordinate, analyze, and make accessible single-cell and other molecular data sets generated by Single-Cell Opioid Responses in the Context of HIV (SCORCH) and other NIDA-funded HIV and substance use disorder projects.
The Departments of Anesthesiology and Neurology Host: “Perivascular Spaces in the Brain & Contributions to Pathology of Cerebral Small Vessel Disease” on March 24
The purpose of this Yale mini-symposium is to highlight the huge unmet clinical need to understand the pathophysiology of small vessel disease to inform future therapeutic efforts to reduce the burden of this illness due to cognitive impairment and dementia. In particular the cellular and molecular mechanisms that underlie diffuse white matter disease and small vessel disease in the brain, the relationships between them, and how they may contribute to cognitive impairment and dementia.
Rakic awarded 2019 Connecticut Medal of Science
The State of Connecticut and Connecticut Academy of Science and Engineering have awarded the 2019 Connecticut Medal of Science to Pasko Rakic, MD, PhD, Dorys McConnell Duberg Professor of Neuroscience and Professor of Neurology at Yale School of Medicine.
Scientists find clues to mystery of Williams Syndrome’s peculiar symptoms
Patients with Williams Syndrome often are extremely social and possess a remarkable affinity and talent for music. They also experience life-threatening cardiovascular problems and developmental disabilities. The mystery is what happens during development to cause such peculiar symptoms.
Barrier Function: TREM2 Helps Microglia to Compact Amyloid Plaques
New research bolsters the case that brain-derived microglia need TREM2 to essentially wall off amyloid plaques, but exactly how they do that remains up for debate. As reported in the May 18 Neuron, scientists led by Jaime Grutzendler at Yale University, New Haven, Connecticut, used confocal and super-resolution microscopy to show that TREM2-positive microglia surround and encase amyloid fibrils, protecting neurons in the process. Yet TREM2 itself appears to lend little support to phagocytosis of Aβ. The technical caliber of the work and the quality of the microscopy led researchers in the AD field to call the study “stunning.” It comes on the heels of another paper, in the April 18 Journal of Experimental Medicine, which suggests the microglia that surround plaques are brain-derived, not peripheral myeloid cells as others had suggested previously.Source: Barrier Function: TREM2 Helps Microglia to Compact Amyloid Plaques
Research in the news: Odor receptors do much more than pick up scents
Smell is the only sensory system with a back up, which throughout most of adult life forms new sensory neurons that express specific odor receptors. Now Yale researchers led by Charles Greer and Diego Rodriguez-Gil have discovered a way to track every step of the process over time.