$15M NIDA Grant Awarded to Serena Spudich, Mark Gerstein, and Yuval Kluger
Principal Investigators Serena Spudich, MD, MA (Neurology), Mark Gerstein, PhD (Molecular Biophysics and Biochemistry), and Yuval Kluger, PhD (Pathology) were recently awarded a $15 million grant from the National Institute on Drug Abuse (NIDA) to establish a Data Center to coordinate, analyze, and make accessible single-cell and other molecular data sets generated by Single-Cell Opioid Responses in the Context of HIV (SCORCH) and other NIDA-funded HIV and substance use disorder projects.
The Departments of Anesthesiology and Neurology Host: “Perivascular Spaces in the Brain & Contributions to Pathology of Cerebral Small Vessel Disease” on March 24
The purpose of this Yale mini-symposium is to highlight the huge unmet clinical need to understand the pathophysiology of small vessel disease to inform future therapeutic efforts to reduce the burden of this illness due to cognitive impairment and dementia. In particular the cellular and molecular mechanisms that underlie diffuse white matter disease and small vessel disease in the brain, the relationships between them, and how they may contribute to cognitive impairment and dementia.
Rakic awarded 2019 Connecticut Medal of Science
The State of Connecticut and Connecticut Academy of Science and Engineering have awarded the 2019 Connecticut Medal of Science to Pasko Rakic, MD, PhD, Dorys McConnell Duberg Professor of Neuroscience and Professor of Neurology at Yale School of Medicine.
Scientists find clues to mystery of Williams Syndrome’s peculiar symptoms
Patients with Williams Syndrome often are extremely social and possess a remarkable affinity and talent for music. They also experience life-threatening cardiovascular problems and developmental disabilities. The mystery is what happens during development to cause such peculiar symptoms.
Barrier Function: TREM2 Helps Microglia to Compact Amyloid Plaques
New research bolsters the case that brain-derived microglia need TREM2 to essentially wall off amyloid plaques, but exactly how they do that remains up for debate. As reported in the May 18 Neuron, scientists led by Jaime Grutzendler at Yale University, New Haven, Connecticut, used confocal and super-resolution microscopy to show that TREM2-positive microglia surround and encase amyloid fibrils, protecting neurons in the process. Yet TREM2 itself appears to lend little support to phagocytosis of Aβ. The technical caliber of the work and the quality of the microscopy led researchers in the AD field to call the study “stunning.” It comes on the heels of another paper, in the April 18 Journal of Experimental Medicine, which suggests the microglia that surround plaques are brain-derived, not peripheral myeloid cells as others had suggested previously.Source: Barrier Function: TREM2 Helps Microglia to Compact Amyloid Plaques
Research in the news: Odor receptors do much more than pick up scents
Smell is the only sensory system with a back up, which throughout most of adult life forms new sensory neurons that express specific odor receptors. Now Yale researchers led by Charles Greer and Diego Rodriguez-Gil have discovered a way to track every step of the process over time.
Immune cells are an ally, not enemy, in battle against Alzheimer’s
In Alzheimer’s disease (AD), β-amyloid plaques are tightly enveloped by microglia but the significance of this phenomenon is unknown. Here the authors used confocal and in vivo two-photon imaging in AD mouse models and revealed that microglia constitute a physical barrier that prevents the formation of neurotoxic hotspots of protofibrillar β-amyloid and shields adjacent neurons and synapses from the toxic effect of amyloid plaques
Eleven young investigators receive grants to pursue brain and behavior research
Eleven Yale investigators have received Young Investigator Grants from the Brain & Behavior Research Foundation (formerly NARSAD). The grants are among $12 million in new funding intended to lead to breakthroughs in understanding and treating mental illness.
Kavli Q&A: Hal Blumenfeld on what epilepsy is teaching us about consciousness
For centuries, the nature of consciousness has been a question for philosophers. That began to change in the late 20th century when scientists such as Francis Crick, the co-discoverer of DNA, argued that it is a tractable scientific problem. Yale’s Hal Blumenfeld is helping to prove Crick right by using the increasingly sophisticated tools of neuroscience to find the biological basis of consciousness.