Yale Study: Ketamine Disinhibits Dendrites and Enhances Calcium Signals in Prefrontal Dendritic Spines
In a study published in Nature Communications, Alex Kwan, PhD, Associate Professor of Psychiatry, and his research team found that within an hour after a mouse received ketamine, there is a substantial increase in the amount of calcium that goes into the dendritic spines for neurons in the prefrontal cortex.
Yale Researchers Measure Ketamine's Effects on a Glutamate Receptor
Sophie Holmes, PhD, Associate Research Scientist in Psychiatry, and Irina Esterlis, PhD, Associate Professor of Psychiatry, are the first and senior authors, respectively, of a study published in Journal of Cerebral Blood Flow & Metabolism that measured the effects of the anesthetic ketamine on a glutamate receptor.
National Academy of Medicine Elects Six Yale Faculty Members
Six Yale School of Medicine faculty members have been elected to the National Academy of Medicine (NAM). The six are among 100 new members elected by the organization to receive the honor, which recognizes individuals who have demonstrated outstanding professional achievement and commitment to service in the fields of health and medicine.
Sestan Among Six Yale Faculty Members Elected to National Academy of Medicine
Nenad Sestan, MD, PhD, Harvey and Kate Cushing Professor of Neuroscience, Professor of Comparative Medicine and of Genetics and Psychiatry, is one of six Yale faculty members elected to the National Academy of Medicine, the organization announced October 21 at its annual meeting.
Research Suggests Male and Female Children's Brains Respond to Differently to Technology
A 2018 study by Marc Potenza, MD, PhD, Professor of Psychiatry, in the Child Study Center and of Neuroscience, is cited in a Wall Street Journal Report that investigates brain differences that cause boys to be more interested in video games and girls to spend more time on social media.
Nasal Spray Offers Hope for Severly Depressed Patients
John H. Krystal, MD, Chair of the Yale Department of Psychiatry, spoke to the Connecticut Health I-Team for a story about the new nasal spray Spravato, which after receiving Food and Drug Administration approval in March is being prescribed for treatment-resistant depression. Krystal is best known for leading the discovery of the rapid antidepressant effects of ketamine in depressed patients. Spravato's chemical name is esketamine, a derivative of ketamine.
Colón-Ramos named McConnell Duberg Associate Professor
Daniel A. Colón-Ramos, PhD, recently appointed as Dorys McConnell Duberg Associate Professor of Neuroscience and Cell Biology, focuses his research on how synapses are formed and maintained to control behavior and store memories. Colón-Ramos’ discoveries have altered long-held views on the process and may offer important clues in the fight against disease.
Picciotto to be Recognized with Marion Spencer Fay Award
The Institute for Women’s Health and Leadership of Drexel University College of Medicine will award its 2020 Marion Spencer Fay Award to Marina Picciotto, PhD, Charles B.G. Murphy Professor of Psychiatry and Professor in the Child Study Center, of Neuroscience and of Pharmacology at Yale School of Medicine.
Yale Researchers Find Genetic Clues to Troubling PTSD Symptom
Symptoms of post-traumatic stress disorder (PTSD) overlap with several other psychiatric disorders, but one specific symptom — repeated disturbing memories and flashbacks about a specific event — is a defining characteristic of debilitating PTSD.
Arnsten Appointed the Kent Professor of Neuroscience and of Psychology
Amy F.T. Arnsten, PhD, recently named as the Albert E. Kent Professor of Neuroscience and of Psychology, studies molecular influences on higher cognitive function, with the aim of developing rational therapies for mental illness and for age-related cognitive disorders such as Alzheimer’s disease.
Elena Gracheva receives a Presidential Award (PECASE)
Elena Gracheva, Associate Professor of Cellular and Molecular Physiology and of Neuroscience, receives a Presidential Early Career Award for Scientists and Engineers (PECASE). The PECASE is the highest honor bestowed by the United States Government to outstanding scientists and engineers who are beginning their independent research careers and who show exceptional promise for leadership in science and technology.
How the Brain Helps Us Make Good Decisions — and Bad Ones
A prevailing theory in neuroscience holds that people make decisions based on integrated global calculations that occur within the frontal cortex of the brain. However, Yale researchers have found that three distinct circuits connecting to different brain regions are involved in making good decisions, bad ones, and determining which of those past choices to store in memory, they report June 25 in the journal Neuron.
The Secret of Autobiographical Memory is in Assembly of Cells
Of all forms of memory, episodic memory is the most intimate. We recall the sequences of events that happen to us — a marriage, a visit to a foreign country, a personal achievement — in great autobiographical detail. But scientists have disagreed about the most important elements the brain uses to encode these episodes and consolidate them during sleep. A group of Yale scientists, however, reports that it is the size and shape of neuronal assemblies — not the strength of signals processed by neurons or the order in which neurons fire — that are the most crucial elements in our ability to record past events.