Duman, Pothula: Cell-type speciﬁc modulation of NMDA receptors triggers antidepressant actions
In a new paper published in Molecular Psychiatry, Santosh Pothula, Post Doctoral Associate in the laboratory of Dr. Ronald S Duman, and the late Ronald Duman, PhD, Elizabeth Mears and House Jameson Professor of Psychiatry and Professor of Neuroscience, and Director of the Abraham Ribicoff Research Facilities, write that both the NMDA receptor (NMDAR) positive allosteric modulator (PAM), and antagonist, can exert rapid antidepressant effects as shown in several animal and human studies. However, how this bidirectional modulation of NMDARs causes similar antidepressant effects remains unknown.Source: Molecular Psychiatry
Elena Gracheva is a finalist of the 2020 Blavatnik National Awards for Young Scientists
Dr. Elena Gracheva, an Associate Professor of Cellular & Molecular Physiology and of Neuroscience, is a 2020 Finalists of the prestigious Blavatnik National Awards for Young Scientists, the world’s largest unrestricted prize for early-career scientists.Source: Elena Gracheva is a finalist of the 2020 Blavatnik National Awards for Young Scientists
Yale Psychiatry's Smith, Sestan Elected to Connecticut Academy of Science and Engineering
Megan Smith, DrPH, MPH, Associate Professor of Psychiatry and Director of the Mental health Outreach for MotherS (MOMS) Partnership, and the Yale Child Study Center Parent and Family Development Program, and Nenad Sestan, MD, PhD, Harvey and Kate Cushing Professor of Neuroscience, and Professor of Comparative Medicine, of Genetics and of Psychiatry, were recently elected to the Connecticut Academy of Science and Engineering (CASE).
Yale Genomics Study: Helping Researchers Better Understand the Opioid Epidemic
A human genomics study led by two Yale Department of Psychiatry researchers identified specific genetic regions that link opioid exposure and dependence to neuropsychiatric traits like risk-taking behaviors, alcohol abuse, and depression.
Yale Study: Ketamine Disinhibits Dendrites and Enhances Calcium Signals in Prefrontal Dendritic Spines
In a study published in Nature Communications, Alex Kwan, PhD, Associate Professor of Psychiatry, and his research team found that within an hour after a mouse received ketamine, there is a substantial increase in the amount of calcium that goes into the dendritic spines for neurons in the prefrontal cortex.
Yale Researchers Measure Ketamine's Effects on a Glutamate Receptor
Sophie Holmes, PhD, Associate Research Scientist in Psychiatry, and Irina Esterlis, PhD, Associate Professor of Psychiatry, are the first and senior authors, respectively, of a study published in Journal of Cerebral Blood Flow & Metabolism that measured the effects of the anesthetic ketamine on a glutamate receptor.
National Academy of Medicine Elects Six Yale Faculty Members
Six Yale School of Medicine faculty members have been elected to the National Academy of Medicine (NAM). The six are among 100 new members elected by the organization to receive the honor, which recognizes individuals who have demonstrated outstanding professional achievement and commitment to service in the fields of health and medicine.Source: YaleNews
Sestan Among Six Yale Faculty Members Elected to National Academy of Medicine
Nenad Sestan, MD, PhD, Harvey and Kate Cushing Professor of Neuroscience, Professor of Comparative Medicine and of Genetics and Psychiatry, is one of six Yale faculty members elected to the National Academy of Medicine, the organization announced October 21 at its annual meeting.
Research Suggests Male and Female Children's Brains Respond to Differently to Technology
A 2018 study by Marc Potenza, MD, PhD, Professor of Psychiatry, in the Child Study Center and of Neuroscience, is cited in a Wall Street Journal Report that investigates brain differences that cause boys to be more interested in video games and girls to spend more time on social media.Source: The Wall Street Journal
Nasal Spray Offers Hope for Severly Depressed Patients
John H. Krystal, MD, Chair of the Yale Department of Psychiatry, spoke to the Connecticut Health I-Team for a story about the new nasal spray Spravato, which after receiving Food and Drug Administration approval in March is being prescribed for treatment-resistant depression. Krystal is best known for leading the discovery of the rapid antidepressant effects of ketamine in depressed patients. Spravato's chemical name is esketamine, a derivative of ketamine.Source: Connecticut Health I-Team
Colón-Ramos named McConnell Duberg Associate Professor
Daniel A. Colón-Ramos, PhD, recently appointed as Dorys McConnell Duberg Associate Professor of Neuroscience and Cell Biology, focuses his research on how synapses are formed and maintained to control behavior and store memories. Colón-Ramos’ discoveries have altered long-held views on the process and may offer important clues in the fight against disease.
Picciotto to be Recognized with Marion Spencer Fay Award
The Institute for Women’s Health and Leadership of Drexel University College of Medicine will award its 2020 Marion Spencer Fay Award to Marina Picciotto, PhD, Charles B.G. Murphy Professor of Psychiatry and Professor in the Child Study Center, of Neuroscience and of Pharmacology at Yale School of Medicine.
Yale Researchers Find Genetic Clues to Troubling PTSD Symptom
Symptoms of post-traumatic stress disorder (PTSD) overlap with several other psychiatric disorders, but one specific symptom — repeated disturbing memories and flashbacks about a specific event — is a defining characteristic of debilitating PTSD.