Yale Study: Ketamine Disinhibits Dendrites and Enhances Calcium Signals in Prefrontal Dendritic Spines
In a study published in Nature Communications, Alex Kwan, PhD, Associate Professor of Psychiatry, and his research team found that within an hour after a mouse received ketamine, there is a substantial increase in the amount of calcium that goes into the dendritic spines for neurons in the prefrontal cortex.
Yale Researchers Measure Ketamine's Effects on a Glutamate Receptor
Sophie Holmes, PhD, Associate Research Scientist in Psychiatry, and Irina Esterlis, PhD, Associate Professor of Psychiatry, are the first and senior authors, respectively, of a study published in Journal of Cerebral Blood Flow & Metabolism that measured the effects of the anesthetic ketamine on a glutamate receptor.
Research Suggests Male and Female Children's Brains Respond to Differently to Technology
A 2018 study by Marc Potenza, MD, PhD, Professor of Psychiatry, in the Child Study Center and of Neuroscience, is cited in a Wall Street Journal Report that investigates brain differences that cause boys to be more interested in video games and girls to spend more time on social media.
Picciotto to be Recognized with Marion Spencer Fay Award
The Institute for Women’s Health and Leadership of Drexel University College of Medicine will award its 2020 Marion Spencer Fay Award to Marina Picciotto, PhD, Charles B.G. Murphy Professor of Psychiatry and Professor in the Child Study Center, of Neuroscience and of Pharmacology at Yale School of Medicine.
Elena Gracheva receives a Presidential Award (PECASE)
Elena Gracheva, Associate Professor of Cellular and Molecular Physiology and of Neuroscience, receives a Presidential Early Career Award for Scientists and Engineers (PECASE). The PECASE is the highest honor bestowed by the United States Government to outstanding scientists and engineers who are beginning their independent research careers and who show exceptional promise for leadership in science and technology.
How the Brain Helps Us Make Good Decisions — and Bad Ones
A prevailing theory in neuroscience holds that people make decisions based on integrated global calculations that occur within the frontal cortex of the brain. However, Yale researchers have found that three distinct circuits connecting to different brain regions are involved in making good decisions, bad ones, and determining which of those past choices to store in memory, they report June 25 in the journal Neuron.
The Secret of Autobiographical Memory is in Assembly of Cells
Of all forms of memory, episodic memory is the most intimate. We recall the sequences of events that happen to us — a marriage, a visit to a foreign country, a personal achievement — in great autobiographical detail. But scientists have disagreed about the most important elements the brain uses to encode these episodes and consolidate them during sleep. A group of Yale scientists, however, reports that it is the size and shape of neuronal assemblies — not the strength of signals processed by neurons or the order in which neurons fire — that are the most crucial elements in our ability to record past events.
Sestan Honored for Research in Developmental Neuroscience
Nenad Sestan, MD, PhD, Harvey and Kate Cushing Professor of Neuroscience, and Professor of Comparative Medicine, Genetics, and Psychiatry, received the Constance Lieber prize for innovation in developmental neuroscience on June 19 at a prize symposium at in Baltimore, MD.
Women’s Health Research at Yale funds studies on pain relief, cannabis, and genetic origins of sex differences in disease
Women’s Health Research at Yale (WHRY) today announced funding for first-of-their-kind studies on pain relief, cannabis, and the genetic basis of sex differences across a broad range of ailments, including Alzheimer’s disease and heart disease.
Krystal Among New Leaders of YCCI
The Yale Center for Clinical Investigation (YCCI) has announced the appointment of Brian R. Smith, MD, and John H. Krystal, MD ’84, as co-directors of the center and co-principal investigators of Yale’s Clinical and Translational Science Award (CTSA). Eric Jose Velazquez, MD, becomes deputy director of clinical trials innovation for YCCI.
Scientists Restore Some Functions in a Pig’s Brain Hours After Death
Circulation and cellular activity were restored in a pig’s brain four hours after its death, a finding that challenges long-held assumptions about the timing and irreversible nature of the cessation of some brain functions after death, Yale scientists report in the journal Nature.
Rakic awarded 2019 Connecticut Medal of Science
The State of Connecticut and Connecticut Academy of Science and Engineering have awarded the 2019 Connecticut Medal of Science to Pasko Rakic, MD, PhD, Dorys McConnell Duberg Professor of Neuroscience and Professor of Neurology at Yale School of Medicine.
Lower synaptic density is associated with depression severity and network alterations
Sophie Holmes, PhD, Associate Research Scientist, and Irina Esterlis, PhD, Associate Professor of Psychiatry, are the first and senior authors, respectively, of a study published in Nature Communications that examined synaptic density in 26 patients with major depressive disorder and post-traumatic stress disorder. The research revealed evidence linking lower synaptic density to network alterations and symptoms of depression.
New Center to Harness Burgeoning Data
The Center for Biomedical Data Science (CBDS) is one part clearinghouse for the newest data-related ideas; one part incubator for ways to educate students, trainees, and faculty on what data can offer; and one part an innovator of data techniques to advance biomedical science and data science. As CBDS matures, additional pursuits are sure to follow.
Krystal and Nunez-Smith Are Honored by Association for Clinical and Translational Science
John H. Krystal, MD, Robert L. McNeil, Jr. Professor of Translational Research, chair and professor of psychiatry, and professor of neuroscience; and Marcella Nunez-Smith, MD, MHS, associate professor of medicine (general medicine) and of epidemiology (chronic diseases), have been chosen for awards by the Association for Clinical and Translational Science.