2023
Rapid fluctuations in functional connectivity of cortical networks encode spontaneous behavior
Benisty H, Barson D, Moberly A, Lohani S, Tang L, Coifman R, Crair M, Mishne G, Cardin J, Higley M. Rapid fluctuations in functional connectivity of cortical networks encode spontaneous behavior. Nature Neuroscience 2023, 27: 148-158. PMID: 38036743, PMCID: PMC11316935, DOI: 10.1038/s41593-023-01498-y.Peer-Reviewed Original ResearchConceptsFunctional connectivitySpontaneous behaviorCortical networksCortical network activityTime-varying functional connectivityFunctional magnetic resonanceCerebral cortexAwake miceDynamic functional connectivityAwake animalsNeighboring neuronsPatterned activityDistinct behavioral statesTwo-photon microscopyNeural activityCortical signalsBehavioral statesCortexNetwork activityCortical dynamicsMagnetic resonanceLongitudinal simultaneous fMRI and mesoscale calcium imaging in a mouse model of Alzheimer’s disease
Mandino F, Shen X, Desrosiers-Gregoire G, O'Connor D, Mukherjee B, DeLuca K, Hamodi A, Owens A, Ha Y, Qu A, Onofrey J, Papademetris X, Chakravarty M, Crair M, Strittmatter S, Lake E. Longitudinal simultaneous fMRI and mesoscale calcium imaging in a mouse model of Alzheimer’s disease. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2023 DOI: 10.58530/2023/3914.Peer-Reviewed Original ResearchMouse model of Alzheimer's diseaseModel of Alzheimer's diseaseMesoscale calcium imagingAlzheimer's diseaseBehavioral deficitsExcitatory neural activityMultimodal neuroimagingBOLD signalSimultaneous fMRINeuroimaging changesNeural activityBOLD fMRIPreliminary evidenceCalcium imagingClinically accessible biomarkersMesoscopic calcium imagingSpontaneous activityFMRINeuroimagingBOLDDeficitsComplex relationship
2014
Visual Circuit Development Requires Patterned Activity Mediated by Retinal Acetylcholine Receptors
Burbridge TJ, Xu HP, Ackman JB, Ge X, Zhang Y, Ye MJ, Zhou ZJ, Xu J, Contractor A, Crair MC. Visual Circuit Development Requires Patterned Activity Mediated by Retinal Acetylcholine Receptors. Neuron 2014, 84: 1049-1064. PMID: 25466916, PMCID: PMC4258148, DOI: 10.1016/j.neuron.2014.10.051.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAge FactorsAnalysis of VarianceAnimalsAnimals, NewbornCalciumCyclic AMPCyclic GMPCyclooxygenase InhibitorsEye ProteinsFunctional LateralityHomeodomain ProteinsIn Vitro TechniquesMeclofenamic AcidMiceMice, TransgenicPaired Box Transcription FactorsPAX6 Transcription FactorReceptors, NicotinicRepressor ProteinsRetinaRetinal Ganglion CellsRNA, MessengerVisual PathwaysConceptsRetinal wavesCircuit refinementNervous systemNeural circuitsVisual circuit developmentSpontaneous retinal activityRetinal activityRetinorecipient regionsSpontaneous activityAcetylcholine receptorsPharmacological manipulationVisual circuitsSynaptic connectionsVertebrate nervous systemNeural activityOnset of sensationAltered patternCircuit developmentSensory systemsCausal linkEarly developmentActivityBrainReceptors
2013
Role of emergent neural activity in visual map development
Ackman JB, Crair MC. Role of emergent neural activity in visual map development. Current Opinion In Neurobiology 2013, 24: 166-175. PMID: 24492092, PMCID: PMC3957181, DOI: 10.1016/j.conb.2013.11.011.Peer-Reviewed Original ResearchConceptsRetinal wavesNeural activitySpontaneous activityNormal visual functionOnset of visionVisual functionGestational periodCalcium influxFunctional visionLong gestational periodNervous systemVisual circuitsNeurotransmitter releaseNerve cellsAssociative circuitsCircuit connectivitySensory-motor systemEye openingFunctional developmentVisuomotor learningSpecific spatiotemporal patternsSpontaneous patternsExcitable cellsOnsetFuture studies
2011
Visualization and Manipulation of Neural Activity in the Developing Vertebrate Nervous System
Zhang J, Ackman JB, Dhande OS, Crair MC. Visualization and Manipulation of Neural Activity in the Developing Vertebrate Nervous System. Frontiers In Molecular Neuroscience 2011, 4: 43. PMID: 22121343, PMCID: PMC3219918, DOI: 10.3389/fnmol.2011.00043.Peer-Reviewed Original Research
1999
Neuronal activity during development: permissive or instructive?
Crair M. Neuronal activity during development: permissive or instructive? Current Opinion In Neurobiology 1999, 9: 88-93. PMID: 10072369, DOI: 10.1016/s0959-4388(99)80011-7.Peer-Reviewed Original Research