2025
Translocating gut pathobiont Enterococcus gallinarum induces TH17 and IgG3 anti-RNA–directed autoimmunity in mouse and human
Gronke K, Nguyen M, Fuhrmann H, Santamaria de Souza N, Schumacher J, Pereira M, Löschberger U, Brinkhege A, Becker N, Yang Y, Sonnert N, Leopold S, Martin A, von Münchow-Klein L, Pessoa Rodrigues C, Cansever D, Hallet R, Richter K, Schubert D, Daniel G, Dylus D, Forkel M, Schwinge D, Schramm C, Redanz S, Lassen K, Manfredo Vieira S, Piali L, Palm N, Bieniossek C, Kriegel M. Translocating gut pathobiont Enterococcus gallinarum induces TH17 and IgG3 anti-RNA–directed autoimmunity in mouse and human. Science Translational Medicine 2025, 17: eadj6294. PMID: 39908347, DOI: 10.1126/scitranslmed.adj6294.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusAutoimmune diseasesToll-like receptor 8Gut pathobiontsHuman adaptive immune responseLong-term sequelaeAdaptive immune responsesHuman T cellsChronic autoimmune diseaseHuman monocyte activationContribution to autoimmunityAutoimmune hepatitisAutoantibody titersAnti-<i>E.Autoimmune pathophysiologyLupus modelT-helperLifelong immunosuppressionTargeted therapyT cellsDisease activityLupus erythematosusAutoantibody responseMonocyte activationImmune response
2024
A microbiota derived metabolite and pediatric celiac disease pathogenesis
Kelley K, Girdhar K, Dogru Y, Yang Y, Tolstikov V, Kiebish M, Palm N, Ludvigsson J, Soto G, Zhang M, Altindis E. A microbiota derived metabolite and pediatric celiac disease pathogenesis. The Journal Of Immunology 2024, 212: 0798_4966-0798_4966. DOI: 10.4049/jimmunol.212.supp.0798.4966.Peer-Reviewed Original ResearchCD progressorsCeliac diseaseLamina propriaVillous atrophyTaurodeoxycholic acidOverexpress IL-15HLA-DQ8 moleculesIncreased IgA responsesNatural killer cellsHLA-DQ8 allelesProspective cohort studyPathogenesis of CDC57BL/B6 micePlasma metabolomeCD4+T cellsKiller cellsT cellsCeliac disease pathogenesisIL-15Autoimmune conditionsHLA-DQ8HLA-DQ2Intraepithelial lymphocytesVilli/crypt ratioCohort study
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